The Relationship Between Intolerance of Uncertainty and Treatment Adherence: The Moderating Effect of Self-Compassion on the Chain Mediation Model
Xinping Shi,1 Yuexia Wang,1 Qisen Jia,2 Shengwei Peng,1,* Xing Liu,1,* Yongju Pei1 1Department of Respiratory and Critical Care Medicine, Henan Provincial People’s Hospital, Zhengzhou, Henan, People’s Republic of China; 2Department of Nursing, Henan Provincial People’s Hospital, Zhen...
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Dove Medical Press
2025-03-01
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| Series: | Patient Preference and Adherence |
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| author | Shi X Wang Y Jia Q Peng S Liu X Pei Y |
| author_facet | Shi X Wang Y Jia Q Peng S Liu X Pei Y |
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| description | Xinping Shi,1 Yuexia Wang,1 Qisen Jia,2 Shengwei Peng,1,* Xing Liu,1,* Yongju Pei1 1Department of Respiratory and Critical Care Medicine, Henan Provincial People’s Hospital, Zhengzhou, Henan, People’s Republic of China; 2Department of Nursing, Henan Provincial People’s Hospital, Zhengzhou, Henan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yongju Pei, Department of Respiratory and Critical Care Medicine, Henan Provincial People’s Hospital, Zhengzhou, Henan, People’s Republic of China, Email de738822@163.comPurpose: The low follow-up compliance of young and middle-aged patients with newly diagnosed pulmonary nodules warrants attention, primarily due to a series of factors such as occupational, familial, and social pressures. Enhancing follow-up adherence is essential for preventing pulmonary nodule progression and reducing lung cancer mortality. Existing research indicates that intolerance of uncertainty is closely associated with patients’ follow-up compliance; however, further in-depth investigation into its influencing mechanisms and potential improvement strategies is required.Patients and Methods: This study conducted a questionnaire survey among 319 young and middle-aged patients newly diagnosed with pulmonary nodules, examining the moderating effect of self-compassion on follow-up compliance and investigating the chain intermediary role of negative interpretation bias and trust in linking intolerance of uncertainty to follow-up compliance.Results: The study found that women, urban residents, and patients over 50 years old demonstrated relatively higher follow-up compliance. Intolerance of uncertainty was found to negatively predict follow-up compliance and indirectly influenced patients’ follow-up behavior through the mediating effects of negative interpretation bias and trust. Furthermore, self-compassion significantly moderated the relationship between trust and follow-up compliance.Conclusion: The findings provide a solid theoretical foundation for developing multidimensional interventions targeting both protective and risk factors. Specifically, mitigating the impact of intolerance of uncertainty on follow-up compliance can improve long-term patient health outcomes. The novel application of the chain mediation model provides valuable insights for future research and clinical practice, particularly in enhancing patient engagement and adherence to follow-up care. Future longitudinal studies are needed to explore additional influencing factors and validate these findings.Keywords: IU, interpretation bias, trust, self-compassion, initial diagnosis of pulmonary nodules, compliance |
| format | Article |
| id | doaj-art-9243e903cfed4e81bf13e678cb4bfc0e |
| institution | Kabale University |
| issn | 1177-889X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Patient Preference and Adherence |
| spelling | doaj-art-9243e903cfed4e81bf13e678cb4bfc0e2025-08-20T03:39:45ZengDove Medical PressPatient Preference and Adherence1177-889X2025-03-01Volume 19699714101351The Relationship Between Intolerance of Uncertainty and Treatment Adherence: The Moderating Effect of Self-Compassion on the Chain Mediation ModelShi XWang YJia QPeng SLiu XPei YXinping Shi,1 Yuexia Wang,1 Qisen Jia,2 Shengwei Peng,1,* Xing Liu,1,* Yongju Pei1 1Department of Respiratory and Critical Care Medicine, Henan Provincial People’s Hospital, Zhengzhou, Henan, People’s Republic of China; 2Department of Nursing, Henan Provincial People’s Hospital, Zhengzhou, Henan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yongju Pei, Department of Respiratory and Critical Care Medicine, Henan Provincial People’s Hospital, Zhengzhou, Henan, People’s Republic of China, Email de738822@163.comPurpose: The low follow-up compliance of young and middle-aged patients with newly diagnosed pulmonary nodules warrants attention, primarily due to a series of factors such as occupational, familial, and social pressures. Enhancing follow-up adherence is essential for preventing pulmonary nodule progression and reducing lung cancer mortality. Existing research indicates that intolerance of uncertainty is closely associated with patients’ follow-up compliance; however, further in-depth investigation into its influencing mechanisms and potential improvement strategies is required.Patients and Methods: This study conducted a questionnaire survey among 319 young and middle-aged patients newly diagnosed with pulmonary nodules, examining the moderating effect of self-compassion on follow-up compliance and investigating the chain intermediary role of negative interpretation bias and trust in linking intolerance of uncertainty to follow-up compliance.Results: The study found that women, urban residents, and patients over 50 years old demonstrated relatively higher follow-up compliance. Intolerance of uncertainty was found to negatively predict follow-up compliance and indirectly influenced patients’ follow-up behavior through the mediating effects of negative interpretation bias and trust. Furthermore, self-compassion significantly moderated the relationship between trust and follow-up compliance.Conclusion: The findings provide a solid theoretical foundation for developing multidimensional interventions targeting both protective and risk factors. Specifically, mitigating the impact of intolerance of uncertainty on follow-up compliance can improve long-term patient health outcomes. The novel application of the chain mediation model provides valuable insights for future research and clinical practice, particularly in enhancing patient engagement and adherence to follow-up care. Future longitudinal studies are needed to explore additional influencing factors and validate these findings.Keywords: IU, interpretation bias, trust, self-compassion, initial diagnosis of pulmonary nodules, compliancehttps://www.dovepress.com/the-relationship-between-intolerance-of-uncertainty-and-treatment-adhe-peer-reviewed-fulltext-article-PPAiuinterpretation biastrustself-compassioninitial diagnosis of pulmonary nodulescompliance |
| spellingShingle | Shi X Wang Y Jia Q Peng S Liu X Pei Y The Relationship Between Intolerance of Uncertainty and Treatment Adherence: The Moderating Effect of Self-Compassion on the Chain Mediation Model Patient Preference and Adherence iu interpretation bias trust self-compassion initial diagnosis of pulmonary nodules compliance |
| title | The Relationship Between Intolerance of Uncertainty and Treatment Adherence: The Moderating Effect of Self-Compassion on the Chain Mediation Model |
| title_full | The Relationship Between Intolerance of Uncertainty and Treatment Adherence: The Moderating Effect of Self-Compassion on the Chain Mediation Model |
| title_fullStr | The Relationship Between Intolerance of Uncertainty and Treatment Adherence: The Moderating Effect of Self-Compassion on the Chain Mediation Model |
| title_full_unstemmed | The Relationship Between Intolerance of Uncertainty and Treatment Adherence: The Moderating Effect of Self-Compassion on the Chain Mediation Model |
| title_short | The Relationship Between Intolerance of Uncertainty and Treatment Adherence: The Moderating Effect of Self-Compassion on the Chain Mediation Model |
| title_sort | relationship between intolerance of uncertainty and treatment adherence the moderating effect of self compassion on the chain mediation model |
| topic | iu interpretation bias trust self-compassion initial diagnosis of pulmonary nodules compliance |
| url | https://www.dovepress.com/the-relationship-between-intolerance-of-uncertainty-and-treatment-adhe-peer-reviewed-fulltext-article-PPA |
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