Cardiac autoantibodies promote a fibrotic transcriptome and reduced ventricular recovery in human myocarditis

Cardiac autoantibodies promote a fibrotic transcriptome and reduced ventricular recovery in human myocarditis

Myocarditis leads to dilated cardiomyopathy (DCM) with one-third failing to recover normal ejection fraction (EF 50%). Our previous studies have supported a Th17 autoimmune pathogenesis where IL17A and IL-6 are elevated in myocarditis patients who do not recover normal EF. In the non-recovered group...

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Bibliographic Details
Main Authors: Jennifer M. Myers, Clayton Sandel, Kathy Alvarez, Lori Garman, Graham Wiley, Courtney Montgomery, Patrick Gaffney, Stavros Stavrakis, DeLisa Fairweather, Katelyn A. Bruno, Yan Daniel Zhao, Leslie T. Cooper, Madeleine W. Cunningham
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
myocarditis
transcriptomics (RNA sequencing)
autoantibodies
cardiomyopathy
autoimmunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1500909/full
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