Perinatal exposure to 4-hydroxy-4′-isopropoxydiphenylsulfone alters the adipogenesis in adult mice: A sex-specific study
4-hydroxy-4′-isopropoxydiphenylsulfone (BPSIP), a common alternative to bisphenol A (BPA), has been detected in breast milk and across placental barriers. However, the long-term impacts of perinatal exposure to BPSIP on adipogenesis and susceptibility to metabolic disorders later in life remain poor...
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Elsevier
2025-07-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325006645 |
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| author | Shengnan Zhang Jiatong Shen Kaini Hu Yitong Zhou Yumeng Wang Xin Wang Kashif Hayat Mingrong Qian |
| author_facet | Shengnan Zhang Jiatong Shen Kaini Hu Yitong Zhou Yumeng Wang Xin Wang Kashif Hayat Mingrong Qian |
| author_sort | Shengnan Zhang |
| collection | DOAJ |
| description | 4-hydroxy-4′-isopropoxydiphenylsulfone (BPSIP), a common alternative to bisphenol A (BPA), has been detected in breast milk and across placental barriers. However, the long-term impacts of perinatal exposure to BPSIP on adipogenesis and susceptibility to metabolic disorders later in life remain poorly understood. This study explored the effects of early-life BPSIP exposure on obesity and metabolic dysfunction in a diet-induced obesity model. Pregnant ICR mice were administered with BPSIP via oral gavage at doses of 0.02, 0.1, and 0.5 mg/kg body weight/day from gestational day 6 to postnatal day 21. After weaning, male and female offspring from control and high dose groups were fed either a normal diet (ND) or a high-fat diet (HFD) for 6 weeks. Results showed that perinatal BPSIP exposure significantly increased serum cholesterol levels, parametrial white adipose tissue (pWAT) weight, and body weight in female offspring, whereas males exhibited the opposite trend. Gene expression analyses revealed sex-specific alterations in adipogenesis, lipid metabolism, and endocrine function within pWAT, with these effects being more pronounced in HFD-fed BPSIP-exposed offspring. These findings demonstrate that perinatal exposure to BPSIP disrupts lipid metabolism in a sex-dependent manner, underscoring the potential long-term metabolic risks associated with BPSIP exposure during critical developmental periods. |
| format | Article |
| id | doaj-art-92332d1bd82e4aada0c546777e5f04ba |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-92332d1bd82e4aada0c546777e5f04ba2025-08-20T03:24:33ZengElsevierEcotoxicology and Environmental Safety0147-65132025-07-0129911832810.1016/j.ecoenv.2025.118328Perinatal exposure to 4-hydroxy-4′-isopropoxydiphenylsulfone alters the adipogenesis in adult mice: A sex-specific studyShengnan Zhang0Jiatong Shen1Kaini Hu2Yitong Zhou3Yumeng Wang4Xin Wang5Kashif Hayat6Mingrong Qian7Zhejiang Collaborative Innovation Center for Full-Process Monitoring and Green Governance of Emerging Contaminants, Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, Interdisciplinary Research Academy, Zhejiang Shuren University, Hangzhou, 310015, ChinaZhejiang Collaborative Innovation Center for Full-Process Monitoring and Green Governance of Emerging Contaminants, Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, Interdisciplinary Research Academy, Zhejiang Shuren University, Hangzhou, 310015, ChinaCollege of Environment, Zhejiang University of Technology, Hangzhou 310032, ChinaZhejiang Collaborative Innovation Center for Full-Process Monitoring and Green Governance of Emerging Contaminants, Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, Interdisciplinary Research Academy, Zhejiang Shuren University, Hangzhou, 310015, ChinaZhejiang Collaborative Innovation Center for Full-Process Monitoring and Green Governance of Emerging Contaminants, Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, Interdisciplinary Research Academy, Zhejiang Shuren University, Hangzhou, 310015, ChinaZhejiang Collaborative Innovation Center for Full-Process Monitoring and Green Governance of Emerging Contaminants, Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, Interdisciplinary Research Academy, Zhejiang Shuren University, Hangzhou, 310015, ChinaZhejiang Collaborative Innovation Center for Full-Process Monitoring and Green Governance of Emerging Contaminants, Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, Interdisciplinary Research Academy, Zhejiang Shuren University, Hangzhou, 310015, ChinaZhejiang Collaborative Innovation Center for Full-Process Monitoring and Green Governance of Emerging Contaminants, Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, Interdisciplinary Research Academy, Zhejiang Shuren University, Hangzhou, 310015, China; Corresponding author.4-hydroxy-4′-isopropoxydiphenylsulfone (BPSIP), a common alternative to bisphenol A (BPA), has been detected in breast milk and across placental barriers. However, the long-term impacts of perinatal exposure to BPSIP on adipogenesis and susceptibility to metabolic disorders later in life remain poorly understood. This study explored the effects of early-life BPSIP exposure on obesity and metabolic dysfunction in a diet-induced obesity model. Pregnant ICR mice were administered with BPSIP via oral gavage at doses of 0.02, 0.1, and 0.5 mg/kg body weight/day from gestational day 6 to postnatal day 21. After weaning, male and female offspring from control and high dose groups were fed either a normal diet (ND) or a high-fat diet (HFD) for 6 weeks. Results showed that perinatal BPSIP exposure significantly increased serum cholesterol levels, parametrial white adipose tissue (pWAT) weight, and body weight in female offspring, whereas males exhibited the opposite trend. Gene expression analyses revealed sex-specific alterations in adipogenesis, lipid metabolism, and endocrine function within pWAT, with these effects being more pronounced in HFD-fed BPSIP-exposed offspring. These findings demonstrate that perinatal exposure to BPSIP disrupts lipid metabolism in a sex-dependent manner, underscoring the potential long-term metabolic risks associated with BPSIP exposure during critical developmental periods.http://www.sciencedirect.com/science/article/pii/S0147651325006645Gestation and lactationBPSIPAdipocyteAdipose tissueFood intake |
| spellingShingle | Shengnan Zhang Jiatong Shen Kaini Hu Yitong Zhou Yumeng Wang Xin Wang Kashif Hayat Mingrong Qian Perinatal exposure to 4-hydroxy-4′-isopropoxydiphenylsulfone alters the adipogenesis in adult mice: A sex-specific study Ecotoxicology and Environmental Safety Gestation and lactation BPSIP Adipocyte Adipose tissue Food intake |
| title | Perinatal exposure to 4-hydroxy-4′-isopropoxydiphenylsulfone alters the adipogenesis in adult mice: A sex-specific study |
| title_full | Perinatal exposure to 4-hydroxy-4′-isopropoxydiphenylsulfone alters the adipogenesis in adult mice: A sex-specific study |
| title_fullStr | Perinatal exposure to 4-hydroxy-4′-isopropoxydiphenylsulfone alters the adipogenesis in adult mice: A sex-specific study |
| title_full_unstemmed | Perinatal exposure to 4-hydroxy-4′-isopropoxydiphenylsulfone alters the adipogenesis in adult mice: A sex-specific study |
| title_short | Perinatal exposure to 4-hydroxy-4′-isopropoxydiphenylsulfone alters the adipogenesis in adult mice: A sex-specific study |
| title_sort | perinatal exposure to 4 hydroxy 4 isopropoxydiphenylsulfone alters the adipogenesis in adult mice a sex specific study |
| topic | Gestation and lactation BPSIP Adipocyte Adipose tissue Food intake |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325006645 |
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