Trimebutine Maleate in the Treatment of Irritable Bowel Syndrome: Canadian Clinical Experience
An open multicentre study was conducted at 18 Canadian centres in patients diagnosed as suffering from irritable bowel syndrome ((BS). One hundred and thirty-one (72%, female and 28% male) patients, mean age 44 years, were treated with 200 mg tid trimebutine maleate (Modulon; Jouveinal) for periods...
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| Format: | Article |
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| Language: | English |
| Published: |
Wiley
1987-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1987/813961 |
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| Summary: | An open multicentre study was conducted at 18 Canadian centres
in patients diagnosed as suffering from irritable bowel syndrome ((BS). One hundred
and thirty-one (72%, female and 28% male) patients, mean age 44 years, were
treated with 200 mg tid trimebutine maleate (Modulon; Jouveinal) for periods of
four weeks. Frequency and severity of pain, constipation and diarrhea were analyzed,
as were stool frequency and consistency. A statistically significant reduction
of frequency and severity was discerned in all symptoms (pain, constipation.
diarrhea). Stool frequency foll within normal range (three per week to three per day)
in close to 90% of patients as compared to 66% prior to the study. Similarly, stool
consistency was normal in over 40% more patients at the end of the study than
before treatment. Global evaluation by physicians and patients showed that approximately
70% of patients felt better at the end of the treatment than before the study.
Side effects such as nausea, headaches and fatigue were reported in 14 patients.leading
to discontinuation of therapy in seven. In conclusion , trimebutine maleate was
effective in reducing the frequency and severity of the major symptoms of IBS as
well as in normalizing transit disturbances as measured by stool frequency. |
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| ISSN: | 0835-7900 |