Workflow of a Preclinical Robotic Magnetic Resonance Imaging-guided Focused Ultrasound Body System
Background: Establishing an efficient workflow is crucial for the success of magnetic resonance-guided focused ultrasound (MRgFUS) procedures. The current study provides a comprehensive description of the workflow of a customized MRgFUS robotic body device for preclinical use and accompanied softwar...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Journal of Medical Ultrasound |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jmu.jmu_135_23 |
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| author | Nikolas Evripidou Anastasia Antoniou George Lazarou Leonidas Georgiou Antreas Chrysanthou Cleanthis Ioannides Christakis Damianou |
| author_facet | Nikolas Evripidou Anastasia Antoniou George Lazarou Leonidas Georgiou Antreas Chrysanthou Cleanthis Ioannides Christakis Damianou |
| author_sort | Nikolas Evripidou |
| collection | DOAJ |
| description | Background:
Establishing an efficient workflow is crucial for the success of magnetic resonance-guided focused ultrasound (MRgFUS) procedures. The current study provides a comprehensive description of the workflow of a customized MRgFUS robotic body device for preclinical use and accompanied software through experiments in excised porcine tissue.
Methods:
The employed system comprises a single-element spherically focused transducer of 2.6 MHz that can be moved along four PC-controlled axes. A detailed description of essential software functionalities and its integration with a 3T Siemens magnetic resonance imaging (MRI) scanner through Access-I for interactive remote control of the scanner and real-time access to imaging data is provided. Following treatment planning on preoperative MR images, porcine tissue samples were sonicated in rectangular and irregular grid patterns with varying ultrasonic parameters and spatial step under software-based monitoring.
Results:
MRgFUS ablations of ex vivo porcine tissue were successfully performed utilizing a multimodal monitoring approach combining MRI-based temperature, thermal dose, and necrotic area mapping, thus demonstrating an efficient procedural workflow. The simulated necrotic regions were in excellent agreement with the actual lesions revealed upon tissue dissection and highly consistent with the planned sonication patterns. The software’s ability to accurately identify regions where necrosis did not occur and indicate to the user the specific points to be re-sonicated was demonstrated.
Conclusion:
Overall, the study highlights critical aspects in accurately planning and executing preclinical MRgFUS protocols within an efficient workflow. The provided data could serve as the basis for other researchers in the field. |
| format | Article |
| id | doaj-art-922bcf92819c44da9248bb577ad5448c |
| institution | OA Journals |
| issn | 0929-6441 2212-1552 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Medical Ultrasound |
| spelling | doaj-art-922bcf92819c44da9248bb577ad5448c2025-08-20T02:15:58ZengWolters Kluwer Medknow PublicationsJournal of Medical Ultrasound0929-64412212-15522025-01-0133111410.4103/jmu.jmu_135_23Workflow of a Preclinical Robotic Magnetic Resonance Imaging-guided Focused Ultrasound Body SystemNikolas EvripidouAnastasia AntoniouGeorge LazarouLeonidas GeorgiouAntreas ChrysanthouCleanthis IoannidesChristakis DamianouBackground: Establishing an efficient workflow is crucial for the success of magnetic resonance-guided focused ultrasound (MRgFUS) procedures. The current study provides a comprehensive description of the workflow of a customized MRgFUS robotic body device for preclinical use and accompanied software through experiments in excised porcine tissue. Methods: The employed system comprises a single-element spherically focused transducer of 2.6 MHz that can be moved along four PC-controlled axes. A detailed description of essential software functionalities and its integration with a 3T Siemens magnetic resonance imaging (MRI) scanner through Access-I for interactive remote control of the scanner and real-time access to imaging data is provided. Following treatment planning on preoperative MR images, porcine tissue samples were sonicated in rectangular and irregular grid patterns with varying ultrasonic parameters and spatial step under software-based monitoring. Results: MRgFUS ablations of ex vivo porcine tissue were successfully performed utilizing a multimodal monitoring approach combining MRI-based temperature, thermal dose, and necrotic area mapping, thus demonstrating an efficient procedural workflow. The simulated necrotic regions were in excellent agreement with the actual lesions revealed upon tissue dissection and highly consistent with the planned sonication patterns. The software’s ability to accurately identify regions where necrosis did not occur and indicate to the user the specific points to be re-sonicated was demonstrated. Conclusion: Overall, the study highlights critical aspects in accurately planning and executing preclinical MRgFUS protocols within an efficient workflow. The provided data could serve as the basis for other researchers in the field.https://journals.lww.com/10.4103/jmu.jmu_135_23magnetic resonance-guided focused ultrasoundplanningrobotic systemsoftwareultrasoundworkflow |
| spellingShingle | Nikolas Evripidou Anastasia Antoniou George Lazarou Leonidas Georgiou Antreas Chrysanthou Cleanthis Ioannides Christakis Damianou Workflow of a Preclinical Robotic Magnetic Resonance Imaging-guided Focused Ultrasound Body System Journal of Medical Ultrasound magnetic resonance-guided focused ultrasound planning robotic system software ultrasound workflow |
| title | Workflow of a Preclinical Robotic Magnetic Resonance Imaging-guided Focused Ultrasound Body System |
| title_full | Workflow of a Preclinical Robotic Magnetic Resonance Imaging-guided Focused Ultrasound Body System |
| title_fullStr | Workflow of a Preclinical Robotic Magnetic Resonance Imaging-guided Focused Ultrasound Body System |
| title_full_unstemmed | Workflow of a Preclinical Robotic Magnetic Resonance Imaging-guided Focused Ultrasound Body System |
| title_short | Workflow of a Preclinical Robotic Magnetic Resonance Imaging-guided Focused Ultrasound Body System |
| title_sort | workflow of a preclinical robotic magnetic resonance imaging guided focused ultrasound body system |
| topic | magnetic resonance-guided focused ultrasound planning robotic system software ultrasound workflow |
| url | https://journals.lww.com/10.4103/jmu.jmu_135_23 |
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