Genome-wide meta-analysis identifies 22 loci for normal tension glaucoma with significant overlap with high tension glaucoma

Genome-wide meta-analysis identifies 22 loci for normal tension glaucoma with significant overlap with high tension glaucoma

Abstract Primary open-angle glaucoma typically presents as two subtypes. This study aimed to elucidate the shared and distinct genetic architectures of normal-tension (NTG) and high-tension glaucoma (HTG), motivated by the need to develop intraocular pressure (IOP)-independent drug targets for the d...

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Main Authors: Santiago Diaz-Torres, Weixiong He, Regina Yu, IGGC International Glaucoma Genetics Consortium, Anthony P. Khawaja, Christopher J. Hammond, Pirro G. Hysi, Louis R. Pasquale, Yeda Wu, Michiaki Kubo, Masato Akiyama, Tin Aung, Ching-Yu Cheng, Chiea Chuen Khor, Peter Kraft, Jae H. Kang, Alex W. Hewitt, David A. Mackey, Jamie E. Craig, Janey L. Wiggs, Jue-Sheng Ong, Stuart MacGregor, Puya Gharahkhani
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54301-2
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