Percutaneous radiofrequency ablation of pancreatic insulinoma: A case report and literature review
Insulinomas are functional neuroendocrine neoplasms arising from the pancreatic islet cells resulting in excess insulin secretion and hypoglycemic episodes. Surgical resection is the standard treatment, but minimally invasive options such as radiofrequency ablation (RFA) have emerged as valuable alt...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-11-01
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| Series: | Radiology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043325007344 |
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| author | Hamidreza Rouientan, MD Shahram Akhlaghpoor, MD |
| author_facet | Hamidreza Rouientan, MD Shahram Akhlaghpoor, MD |
| author_sort | Hamidreza Rouientan, MD |
| collection | DOAJ |
| description | Insulinomas are functional neuroendocrine neoplasms arising from the pancreatic islet cells resulting in excess insulin secretion and hypoglycemic episodes. Surgical resection is the standard treatment, but minimally invasive options such as radiofrequency ablation (RFA) have emerged as valuable alternatives, especially for nonsurgical candidates. We present the case of a 38-year-old male experiencing repeated episodes of critical hypoglycemia secondary to a pancreatic insulinoma, confirmed by elevated insulin and C-peptide levels and imaging findings. Initial surgical resection was unsuccessful due to intraoperative difficulty in localizing the lesion. The patient was subsequently treated with percutaneous RFA. Following the procedure, he developed mild pancreatitis, which was managed conservatively with complete resolution Follow-up at 12 months showed significant clinical improvement, normalization of insulin levels, and no evidence of tumor recurrence. |
| format | Article |
| id | doaj-art-922902bc0a3a4eaab9e06b889eee3608 |
| institution | Kabale University |
| issn | 1930-0433 |
| language | English |
| publishDate | 2025-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj-art-922902bc0a3a4eaab9e06b889eee36082025-08-26T04:14:12ZengElsevierRadiology Case Reports1930-04332025-11-0120115696570110.1016/j.radcr.2025.07.065Percutaneous radiofrequency ablation of pancreatic insulinoma: A case report and literature reviewHamidreza Rouientan, MD0Shahram Akhlaghpoor, MD1Department of Interventional Radiology, Pardis Noor Medical Imaging and Cancer Center, Tehran, IranCorresponding author.; Department of Interventional Radiology, Pardis Noor Medical Imaging and Cancer Center, Tehran, IranInsulinomas are functional neuroendocrine neoplasms arising from the pancreatic islet cells resulting in excess insulin secretion and hypoglycemic episodes. Surgical resection is the standard treatment, but minimally invasive options such as radiofrequency ablation (RFA) have emerged as valuable alternatives, especially for nonsurgical candidates. We present the case of a 38-year-old male experiencing repeated episodes of critical hypoglycemia secondary to a pancreatic insulinoma, confirmed by elevated insulin and C-peptide levels and imaging findings. Initial surgical resection was unsuccessful due to intraoperative difficulty in localizing the lesion. The patient was subsequently treated with percutaneous RFA. Following the procedure, he developed mild pancreatitis, which was managed conservatively with complete resolution Follow-up at 12 months showed significant clinical improvement, normalization of insulin levels, and no evidence of tumor recurrence.http://www.sciencedirect.com/science/article/pii/S1930043325007344Radiofrequency ablationInterventional oncologyInsulinomaCase reportInterventional radiology |
| spellingShingle | Hamidreza Rouientan, MD Shahram Akhlaghpoor, MD Percutaneous radiofrequency ablation of pancreatic insulinoma: A case report and literature review Radiology Case Reports Radiofrequency ablation Interventional oncology Insulinoma Case report Interventional radiology |
| title | Percutaneous radiofrequency ablation of pancreatic insulinoma: A case report and literature review |
| title_full | Percutaneous radiofrequency ablation of pancreatic insulinoma: A case report and literature review |
| title_fullStr | Percutaneous radiofrequency ablation of pancreatic insulinoma: A case report and literature review |
| title_full_unstemmed | Percutaneous radiofrequency ablation of pancreatic insulinoma: A case report and literature review |
| title_short | Percutaneous radiofrequency ablation of pancreatic insulinoma: A case report and literature review |
| title_sort | percutaneous radiofrequency ablation of pancreatic insulinoma a case report and literature review |
| topic | Radiofrequency ablation Interventional oncology Insulinoma Case report Interventional radiology |
| url | http://www.sciencedirect.com/science/article/pii/S1930043325007344 |
| work_keys_str_mv | AT hamidrezarouientanmd percutaneousradiofrequencyablationofpancreaticinsulinomaacasereportandliteraturereview AT shahramakhlaghpoormd percutaneousradiofrequencyablationofpancreaticinsulinomaacasereportandliteraturereview |