Optimizing Liquid Electron Ionization Interface to Boost LC-MS Instrumental Efficiency
Liquid Electron Ionization (LEI) is a powerful and robust interface for the qualitative and quantitative analysis of medium-low-molecular-weight compounds, including numerous environmental pollutants and toxicological substances. Although the robustness and performance of this interface have already...
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MDPI AG
2025-04-01
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| Online Access: | https://www.mdpi.com/2297-8739/12/5/105 |
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| author | Tommaso Grazioso Genny Grasselli Adriana Arigò Giorgio Famiglini Achille Cappiello |
| author_facet | Tommaso Grazioso Genny Grasselli Adriana Arigò Giorgio Famiglini Achille Cappiello |
| author_sort | Tommaso Grazioso |
| collection | DOAJ |
| description | Liquid Electron Ionization (LEI) is a powerful and robust interface for the qualitative and quantitative analysis of medium-low-molecular-weight compounds, including numerous environmental pollutants and toxicological substances. Although the robustness and performance of this interface have already been demonstrated, research on its optimization can still improve instrumental performance in terms of detectability. In this study, different setups of the interface’s vaporization micro-channel (VMC) made using different capillaries and various sizes were tested to evaluate the correspondent instrumental performance. The results show that a new combination of capillaries in the interface set up significantly improves instrumental detectability, reaching LOD values almost five times lower than those of the previous setup. |
| format | Article |
| id | doaj-art-9226f4f2a1a644da8f443149712e9aa7 |
| institution | DOAJ |
| issn | 2297-8739 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
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| spelling | doaj-art-9226f4f2a1a644da8f443149712e9aa72025-08-20T03:12:09ZengMDPI AGSeparations2297-87392025-04-0112510510.3390/separations12050105Optimizing Liquid Electron Ionization Interface to Boost LC-MS Instrumental EfficiencyTommaso Grazioso0Genny Grasselli1Adriana Arigò2Giorgio Famiglini3Achille Cappiello4Department of Pure and Applied Sciences, University of Urbino Carlo Bo, 61029 Urbino, ItalyDepartment of Pure and Applied Sciences, University of Urbino Carlo Bo, 61029 Urbino, ItalyDepartment of Pure and Applied Sciences, University of Urbino Carlo Bo, 61029 Urbino, ItalyDepartment of Pure and Applied Sciences, University of Urbino Carlo Bo, 61029 Urbino, ItalyDepartment of Pure and Applied Sciences, University of Urbino Carlo Bo, 61029 Urbino, ItalyLiquid Electron Ionization (LEI) is a powerful and robust interface for the qualitative and quantitative analysis of medium-low-molecular-weight compounds, including numerous environmental pollutants and toxicological substances. Although the robustness and performance of this interface have already been demonstrated, research on its optimization can still improve instrumental performance in terms of detectability. In this study, different setups of the interface’s vaporization micro-channel (VMC) made using different capillaries and various sizes were tested to evaluate the correspondent instrumental performance. The results show that a new combination of capillaries in the interface set up significantly improves instrumental detectability, reaching LOD values almost five times lower than those of the previous setup.https://www.mdpi.com/2297-8739/12/5/105LC-EI-MSLEIliquid chromatographymass spectrometry |
| spellingShingle | Tommaso Grazioso Genny Grasselli Adriana Arigò Giorgio Famiglini Achille Cappiello Optimizing Liquid Electron Ionization Interface to Boost LC-MS Instrumental Efficiency Separations LC-EI-MS LEI liquid chromatography mass spectrometry |
| title | Optimizing Liquid Electron Ionization Interface to Boost LC-MS Instrumental Efficiency |
| title_full | Optimizing Liquid Electron Ionization Interface to Boost LC-MS Instrumental Efficiency |
| title_fullStr | Optimizing Liquid Electron Ionization Interface to Boost LC-MS Instrumental Efficiency |
| title_full_unstemmed | Optimizing Liquid Electron Ionization Interface to Boost LC-MS Instrumental Efficiency |
| title_short | Optimizing Liquid Electron Ionization Interface to Boost LC-MS Instrumental Efficiency |
| title_sort | optimizing liquid electron ionization interface to boost lc ms instrumental efficiency |
| topic | LC-EI-MS LEI liquid chromatography mass spectrometry |
| url | https://www.mdpi.com/2297-8739/12/5/105 |
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