On reduced-order modeling of drug dispersion in the spinal canal
Abstract The optimization of intrathecal drug delivery procedures requires a deeper understanding of flow and transport in the spinal canal. Numerical modeling of drug dispersion is challenging due to the disparity in time scales: dispersion occurs over 1 hour, while cerebrospinal fluid pulsations d...
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| Main Authors: | F. J. Parras-Martos, A. L. Sánchez, C. Martínez-Bazán, W. Coenen, C. Gutiérrez-Montes |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-07-01
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| Series: | Fluids and Barriers of the CNS |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12987-025-00657-6 |
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