On reduced-order modeling of drug dispersion in the spinal canal

Abstract The optimization of intrathecal drug delivery procedures requires a deeper understanding of flow and transport in the spinal canal. Numerical modeling of drug dispersion is challenging due to the disparity in time scales: dispersion occurs over 1 hour, while cerebrospinal fluid pulsations d...

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Bibliographic Details
Main Authors: F. J. Parras-Martos, A. L. Sánchez, C. Martínez-Bazán, W. Coenen, C. Gutiérrez-Montes
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Fluids and Barriers of the CNS
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Online Access:https://doi.org/10.1186/s12987-025-00657-6
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