Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men
Obesity and aging are major risk factors for several life-threatening diseases. Accumulating evidence from both rodents and humans suggests that the levels of nicotinamide adenine dinucleotide (NAD+), a regulator of many biological processes, declines in multiple organs and tissues with aging and ob...
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| Format: | Article |
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The Japan Endocrine Society
2024-02-01
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| Series: | Endocrine Journal |
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| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/71/2/71_EJ23-0431/_html/-char/en |
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| author | Shintaro Yamaguchi Junichiro Irie Masanori Mitsuishi Yuichi Uchino Hideaki Nakaya Ryo Takemura Emi Inagaki Shotaro Kosugi Hideyuki Okano Masato Yasui Kazuo Tsubota Kaori Hayashi Jun Yoshino Hiroshi Itoh |
| author_facet | Shintaro Yamaguchi Junichiro Irie Masanori Mitsuishi Yuichi Uchino Hideaki Nakaya Ryo Takemura Emi Inagaki Shotaro Kosugi Hideyuki Okano Masato Yasui Kazuo Tsubota Kaori Hayashi Jun Yoshino Hiroshi Itoh |
| author_sort | Shintaro Yamaguchi |
| collection | DOAJ |
| description | Obesity and aging are major risk factors for several life-threatening diseases. Accumulating evidence from both rodents and humans suggests that the levels of nicotinamide adenine dinucleotide (NAD+), a regulator of many biological processes, declines in multiple organs and tissues with aging and obesity. Administration of an NAD+ intermediate, nicotinamide mononucleotide (NMN), replenishes intracellular NAD+ levels and mitigates aging- and obesity-associated derangements in animal models. In this human clinical study, we aimed to investigate the safety and effects of 8-week oral administration of NMN on biochemical, metabolic, ophthalmologic, and sleep quality parameters as well as on chronological alterations in NAD+ content in peripheral tissues. An 8-week, single-center, single-arm, open-label clinical trial was conducted. Eleven healthy, middle-aged Japanese men received two 125-mg NMN capsules once daily before breakfast. The 8-week NMN supplementation regimen was well-tolerated; NAD+ levels in peripheral blood mononuclear cells increased over the course of NMN administration. In participants with insulin oversecretion after oral glucose loading, NMN modestly attenuated postprandial hyperinsulinemia, a risk factor for coronary artery disease (n = 3). In conclusion, NMN overall safely and effectively boosted NAD+ biosynthesis in healthy, middle-aged Japanese men, showing its potential for alleviating postprandial hyperinsulinemia. |
| format | Article |
| id | doaj-art-92235c5b076e4e6488506b52c2421753 |
| institution | Kabale University |
| issn | 1348-4540 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | The Japan Endocrine Society |
| record_format | Article |
| series | Endocrine Journal |
| spelling | doaj-art-92235c5b076e4e6488506b52c24217532025-01-22T06:33:21ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402024-02-0171215316910.1507/endocrj.EJ23-0431endocrjSafety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese menShintaro Yamaguchi0Junichiro Irie1Masanori Mitsuishi2Yuichi Uchino3Hideaki Nakaya4Ryo Takemura5Emi Inagaki6Shotaro Kosugi7Hideyuki Okano8Masato Yasui9Kazuo Tsubota10Kaori Hayashi11Jun Yoshino12Hiroshi Itoh13Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, JapanDivision of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, JapanDivision of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, JapanDepartment of Ophthalmology, Keio University School of Medicine, Tokyo 160-8582, JapanDivision of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, JapanBiostatistics Unit, Clinical and Translational Research Center, Keio University Hospital, Tokyo 160-8582, JapanDepartment of Ophthalmology, Keio University School of Medicine, Tokyo 160-8582, JapanDivision of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, JapanDepartment of Physiology, Keio University School of Medicine, Tokyo 160-8582, JapanDepartment of Pharmacology, Keio University School of Medicine, Tokyo 160-8582, JapanDepartment of Ophthalmology, Keio University School of Medicine, Tokyo 160-8582, JapanDivision of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, JapanDivision of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, JapanDivision of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, JapanObesity and aging are major risk factors for several life-threatening diseases. Accumulating evidence from both rodents and humans suggests that the levels of nicotinamide adenine dinucleotide (NAD+), a regulator of many biological processes, declines in multiple organs and tissues with aging and obesity. Administration of an NAD+ intermediate, nicotinamide mononucleotide (NMN), replenishes intracellular NAD+ levels and mitigates aging- and obesity-associated derangements in animal models. In this human clinical study, we aimed to investigate the safety and effects of 8-week oral administration of NMN on biochemical, metabolic, ophthalmologic, and sleep quality parameters as well as on chronological alterations in NAD+ content in peripheral tissues. An 8-week, single-center, single-arm, open-label clinical trial was conducted. Eleven healthy, middle-aged Japanese men received two 125-mg NMN capsules once daily before breakfast. The 8-week NMN supplementation regimen was well-tolerated; NAD+ levels in peripheral blood mononuclear cells increased over the course of NMN administration. In participants with insulin oversecretion after oral glucose loading, NMN modestly attenuated postprandial hyperinsulinemia, a risk factor for coronary artery disease (n = 3). In conclusion, NMN overall safely and effectively boosted NAD+ biosynthesis in healthy, middle-aged Japanese men, showing its potential for alleviating postprandial hyperinsulinemia.https://www.jstage.jst.go.jp/article/endocrj/71/2/71_EJ23-0431/_html/-char/ennicotinamide mononucleotidenicotinamide adenine dinucleotidemetabolismpostprandial hyperinsulinemia |
| spellingShingle | Shintaro Yamaguchi Junichiro Irie Masanori Mitsuishi Yuichi Uchino Hideaki Nakaya Ryo Takemura Emi Inagaki Shotaro Kosugi Hideyuki Okano Masato Yasui Kazuo Tsubota Kaori Hayashi Jun Yoshino Hiroshi Itoh Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men Endocrine Journal nicotinamide mononucleotide nicotinamide adenine dinucleotide metabolism postprandial hyperinsulinemia |
| title | Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men |
| title_full | Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men |
| title_fullStr | Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men |
| title_full_unstemmed | Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men |
| title_short | Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men |
| title_sort | safety and efficacy of long term nicotinamide mononucleotide supplementation on metabolism sleep and nicotinamide adenine dinucleotide biosynthesis in healthy middle aged japanese men |
| topic | nicotinamide mononucleotide nicotinamide adenine dinucleotide metabolism postprandial hyperinsulinemia |
| url | https://www.jstage.jst.go.jp/article/endocrj/71/2/71_EJ23-0431/_html/-char/en |
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