More Than Just Tumor Destruction: Immunomodulation by Thermal Ablation of Cancer
Over the past decades, thermoablative techniques for the therapy of localized tumors have gained importance in the treatment of patients not eligible for surgical resection. Anecdotal reports have described spontaneous distant tumor regression after thermal ablation, indicating a possible involvemen...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2011/160250 |
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| author | Sebastian P. Haen Philippe L. Pereira Helmut R. Salih Hans-Georg Rammensee Cécile Gouttefangeas |
| author_facet | Sebastian P. Haen Philippe L. Pereira Helmut R. Salih Hans-Georg Rammensee Cécile Gouttefangeas |
| author_sort | Sebastian P. Haen |
| collection | DOAJ |
| description | Over the past decades, thermoablative techniques for the therapy of localized tumors have gained importance in the treatment of patients not eligible for surgical resection. Anecdotal reports have described spontaneous distant tumor regression after thermal ablation, indicating a possible involvement of the immune system, hence an induction of antitumor immunity after thermoinduced therapy. In recent years, a growing body of evidence for modulation of both adaptive and innate immunity, as well as for the induction of danger signals through thermoablation, has emerged. Induced immune responses, however, are mostly weak and not sufficient for the complete eradication of established tumors or durable prevention of disease progression, and combination therapies with immunomodulating drugs are being evaluated with promising results. This article aims to summarize published findings on immune modulation through radiofrequency ablation, cryoablation, microwave ablation therapy, high-intensity focused ultrasound, and laser-induced thermotherapy. |
| format | Article |
| id | doaj-art-921c869b78f941eaa58b117c403fd6f0 |
| institution | OA Journals |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-921c869b78f941eaa58b117c403fd6f02025-08-20T02:09:55ZengWileyClinical and Developmental Immunology1740-25221740-25302011-01-01201110.1155/2011/160250160250More Than Just Tumor Destruction: Immunomodulation by Thermal Ablation of CancerSebastian P. Haen0Philippe L. Pereira1Helmut R. Salih2Hans-Georg Rammensee3Cécile Gouttefangeas4Abteilung II fuer Onkologie, Haematologie, Immunologie, Rheumatologie, und Pulmologie, Medizinische Universitaetsklinik, Otfried Mueller Straße 10, 72076 Tuebingen, GermanyKlinik fuer Radiologie, Minimalinvasive Therapien, und Nuklearmedizin, SLK-Kliniken Heilbronn, Am Gesundbrunnen 20-26, 74078 Heilbronn, GermanyAbteilung II fuer Onkologie, Haematologie, Immunologie, Rheumatologie, und Pulmologie, Medizinische Universitaetsklinik, Otfried Mueller Straße 10, 72076 Tuebingen, GermanyAbteilung Immunologie, Interfakultaeres Institut fuer Zellbiologie, Auf der Morgenstelle 15, 72076 Tuebingen, GermanyAbteilung Immunologie, Interfakultaeres Institut fuer Zellbiologie, Auf der Morgenstelle 15, 72076 Tuebingen, GermanyOver the past decades, thermoablative techniques for the therapy of localized tumors have gained importance in the treatment of patients not eligible for surgical resection. Anecdotal reports have described spontaneous distant tumor regression after thermal ablation, indicating a possible involvement of the immune system, hence an induction of antitumor immunity after thermoinduced therapy. In recent years, a growing body of evidence for modulation of both adaptive and innate immunity, as well as for the induction of danger signals through thermoablation, has emerged. Induced immune responses, however, are mostly weak and not sufficient for the complete eradication of established tumors or durable prevention of disease progression, and combination therapies with immunomodulating drugs are being evaluated with promising results. This article aims to summarize published findings on immune modulation through radiofrequency ablation, cryoablation, microwave ablation therapy, high-intensity focused ultrasound, and laser-induced thermotherapy.http://dx.doi.org/10.1155/2011/160250 |
| spellingShingle | Sebastian P. Haen Philippe L. Pereira Helmut R. Salih Hans-Georg Rammensee Cécile Gouttefangeas More Than Just Tumor Destruction: Immunomodulation by Thermal Ablation of Cancer Clinical and Developmental Immunology |
| title | More Than Just Tumor Destruction: Immunomodulation by Thermal Ablation of Cancer |
| title_full | More Than Just Tumor Destruction: Immunomodulation by Thermal Ablation of Cancer |
| title_fullStr | More Than Just Tumor Destruction: Immunomodulation by Thermal Ablation of Cancer |
| title_full_unstemmed | More Than Just Tumor Destruction: Immunomodulation by Thermal Ablation of Cancer |
| title_short | More Than Just Tumor Destruction: Immunomodulation by Thermal Ablation of Cancer |
| title_sort | more than just tumor destruction immunomodulation by thermal ablation of cancer |
| url | http://dx.doi.org/10.1155/2011/160250 |
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