The Potential of Curcumin in Treatment of Spinal Cord Injury
Current treatment for spinal cord injury (SCI) is supportive at best; despite great efforts, the lack of better treatment solutions looms large on neurological science and medicine. Curcumin, the active ingredient in turmeric, a spice known for its medicinal and anti-inflammatory properties, has bee...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2016/9468193 |
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| author | Raghavendra Sanivarapu Vijayalakshmi Vallabhaneni Vivek Verma |
| author_facet | Raghavendra Sanivarapu Vijayalakshmi Vallabhaneni Vivek Verma |
| author_sort | Raghavendra Sanivarapu |
| collection | DOAJ |
| description | Current treatment for spinal cord injury (SCI) is supportive at best; despite great efforts, the lack of better treatment solutions looms large on neurological science and medicine. Curcumin, the active ingredient in turmeric, a spice known for its medicinal and anti-inflammatory properties, has been validated to harbor immense effects for a multitude of inflammatory-based diseases. However, to date there has not been a review on curcumin’s effects on SCI. Herein, we systematically review all known data on this topic and juxtapose results of curcumin with standard therapies such as corticosteroids. Because all studies that compare the two show superior results for curcumin over corticosteroids, it could be true that curcumin better acts at the inflammatory source of SCI-mediated neurological injury, although this question remains unanswered in patients. Because curcumin has shown improvements from current standards of care in other diseases with few true treatment options (e.g., osteoarthritis), there is immense potential for this compound in treating SCI. We critically and systematically summarize available data, discuss clinical implications, and propose further testing of this well-tolerated compound in both the preclinical and the clinical realms. Analyzing preclinical data from a clinical perspective, we hope to create awareness of the incredible potential that curcumin shows for SCI in a patient population that direly needs improvements on current therapy. |
| format | Article |
| id | doaj-art-921be765274c4c5caf39561e1e1288ce |
| institution | Kabale University |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-921be765274c4c5caf39561e1e1288ce2025-02-03T06:00:35ZengWileyNeurology Research International2090-18522090-18602016-01-01201610.1155/2016/94681939468193The Potential of Curcumin in Treatment of Spinal Cord InjuryRaghavendra Sanivarapu0Vijayalakshmi Vallabhaneni1Vivek Verma2Nassau University Medical Center, East Meadow, NY 11554, USADepartment of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USADepartment of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE 68198, USACurrent treatment for spinal cord injury (SCI) is supportive at best; despite great efforts, the lack of better treatment solutions looms large on neurological science and medicine. Curcumin, the active ingredient in turmeric, a spice known for its medicinal and anti-inflammatory properties, has been validated to harbor immense effects for a multitude of inflammatory-based diseases. However, to date there has not been a review on curcumin’s effects on SCI. Herein, we systematically review all known data on this topic and juxtapose results of curcumin with standard therapies such as corticosteroids. Because all studies that compare the two show superior results for curcumin over corticosteroids, it could be true that curcumin better acts at the inflammatory source of SCI-mediated neurological injury, although this question remains unanswered in patients. Because curcumin has shown improvements from current standards of care in other diseases with few true treatment options (e.g., osteoarthritis), there is immense potential for this compound in treating SCI. We critically and systematically summarize available data, discuss clinical implications, and propose further testing of this well-tolerated compound in both the preclinical and the clinical realms. Analyzing preclinical data from a clinical perspective, we hope to create awareness of the incredible potential that curcumin shows for SCI in a patient population that direly needs improvements on current therapy.http://dx.doi.org/10.1155/2016/9468193 |
| spellingShingle | Raghavendra Sanivarapu Vijayalakshmi Vallabhaneni Vivek Verma The Potential of Curcumin in Treatment of Spinal Cord Injury Neurology Research International |
| title | The Potential of Curcumin in Treatment of Spinal Cord Injury |
| title_full | The Potential of Curcumin in Treatment of Spinal Cord Injury |
| title_fullStr | The Potential of Curcumin in Treatment of Spinal Cord Injury |
| title_full_unstemmed | The Potential of Curcumin in Treatment of Spinal Cord Injury |
| title_short | The Potential of Curcumin in Treatment of Spinal Cord Injury |
| title_sort | potential of curcumin in treatment of spinal cord injury |
| url | http://dx.doi.org/10.1155/2016/9468193 |
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