CXCR4 and Axillary Lymph Nodes: Review of a Potential Biomarker for Breast Cancer Metastasis
CXCR4 is a 7-transmembrane G-protein chemokine receptor that allows for migration of hematopoietic cells from the bone marrow to the peripheral lymph nodes. Research has shown CXCR4 to be implicated in the invasion and metastasis of several cancers, including carcinoma of the breast. CXCL12 is the l...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
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| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.4061/2011/420981 |
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| _version_ | 1832552790734405632 |
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| author | David Hiller Quyen D. Chu |
| author_facet | David Hiller Quyen D. Chu |
| author_sort | David Hiller |
| collection | DOAJ |
| description | CXCR4 is a 7-transmembrane G-protein chemokine receptor that allows for migration of hematopoietic cells from the bone marrow to the peripheral lymph nodes. Research has shown CXCR4 to be implicated in the invasion and metastasis of several cancers, including carcinoma of the breast. CXCL12 is the ligand for CXCR4 and is highly expressed in areas common for breast cancer metastasis, including the axillary lymph nodes. Axillary lymph nodes positive for breast carcinoma have been an important component of breast cancer diagnosis, treatment, and subsequent research. The goal of this paper is to analyze the literature that has explained the pathways from CXCR4 expression to breast cancer metastasis of the lymph nodes and the prognostic and/or predictive implications of lymph node metastases in the presence of elevated CXCR4. |
| format | Article |
| id | doaj-art-921bad1838974444a68842a9e680cf62 |
| institution | Kabale University |
| issn | 2090-3189 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-921bad1838974444a68842a9e680cf622025-02-03T05:57:49ZengWileyInternational Journal of Breast Cancer2090-31892011-01-01201110.4061/2011/420981420981CXCR4 and Axillary Lymph Nodes: Review of a Potential Biomarker for Breast Cancer MetastasisDavid Hiller0Quyen D. Chu1Division of Surgical Oncology, Department of Surgery, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USADivision of Surgical Oncology, Department of Surgery, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USACXCR4 is a 7-transmembrane G-protein chemokine receptor that allows for migration of hematopoietic cells from the bone marrow to the peripheral lymph nodes. Research has shown CXCR4 to be implicated in the invasion and metastasis of several cancers, including carcinoma of the breast. CXCL12 is the ligand for CXCR4 and is highly expressed in areas common for breast cancer metastasis, including the axillary lymph nodes. Axillary lymph nodes positive for breast carcinoma have been an important component of breast cancer diagnosis, treatment, and subsequent research. The goal of this paper is to analyze the literature that has explained the pathways from CXCR4 expression to breast cancer metastasis of the lymph nodes and the prognostic and/or predictive implications of lymph node metastases in the presence of elevated CXCR4.http://dx.doi.org/10.4061/2011/420981 |
| spellingShingle | David Hiller Quyen D. Chu CXCR4 and Axillary Lymph Nodes: Review of a Potential Biomarker for Breast Cancer Metastasis International Journal of Breast Cancer |
| title | CXCR4 and Axillary Lymph Nodes: Review of a Potential Biomarker for Breast Cancer Metastasis |
| title_full | CXCR4 and Axillary Lymph Nodes: Review of a Potential Biomarker for Breast Cancer Metastasis |
| title_fullStr | CXCR4 and Axillary Lymph Nodes: Review of a Potential Biomarker for Breast Cancer Metastasis |
| title_full_unstemmed | CXCR4 and Axillary Lymph Nodes: Review of a Potential Biomarker for Breast Cancer Metastasis |
| title_short | CXCR4 and Axillary Lymph Nodes: Review of a Potential Biomarker for Breast Cancer Metastasis |
| title_sort | cxcr4 and axillary lymph nodes review of a potential biomarker for breast cancer metastasis |
| url | http://dx.doi.org/10.4061/2011/420981 |
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