Fetuin-A Characteristics during and after Pregnancy: Result from a Case Control Pilot Study
Objective. Fetuin-A has been associated with gestational diabetes mellitus (GDM). We investigated fetuin-A levels during and after pregnancy in women with GDM. Fetuin-A measurements were performed in 10 women with GDM and 10 age and body mass index (BMI) matched healthy pregnant women. All women und...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2012/896736 |
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| _version_ | 1832551473568808960 |
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| author | Serdar Farhan Ammon Handisurya Jelena Todoric Andrea Tura Giovanni Pacini Oswald Wagner Katharina Klein Rudolf Jarai Kurt Huber Alexandra Kautzky-Willer |
| author_facet | Serdar Farhan Ammon Handisurya Jelena Todoric Andrea Tura Giovanni Pacini Oswald Wagner Katharina Klein Rudolf Jarai Kurt Huber Alexandra Kautzky-Willer |
| author_sort | Serdar Farhan |
| collection | DOAJ |
| description | Objective. Fetuin-A has been associated with gestational diabetes mellitus (GDM). We investigated fetuin-A levels during and after pregnancy in women with GDM. Fetuin-A measurements were performed in 10 women with GDM and 10 age and body mass index (BMI) matched healthy pregnant women. All women underwent an oral glucose tolerance test (OGTT) in and 3 months after gestation.
Results. Fasting fetuin-A correlated with BMI in women with former GDM (r=0.90, P<0.0001) but showed no association with parameters of glucose tolerance in women with GDM or post-GDM. GDM featured significantly lower insulin sensitivity and higher insulin and C-peptide secretion profiles compared to NGT during pregnancy (P<0.05). Fasting and postprandial fetuin-A did not differ between groups, neither during nor after pregnancy.
Conclusion. Fetuin-A is not influenced by glucose tolerance during or after pregnancy or acute glucose elevations following glucose ingestion in young women, but closely relates to BMI early postpartum. |
| format | Article |
| id | doaj-art-9218134808234be4908268b33ce93cf4 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-9218134808234be4908268b33ce93cf42025-02-03T06:01:26ZengWileyInternational Journal of Endocrinology1687-83371687-83452012-01-01201210.1155/2012/896736896736Fetuin-A Characteristics during and after Pregnancy: Result from a Case Control Pilot StudySerdar Farhan0Ammon Handisurya1Jelena Todoric2Andrea Tura3Giovanni Pacini4Oswald Wagner5Katharina Klein6Rudolf Jarai7Kurt Huber8Alexandra Kautzky-Willer93rd Department of Medicine, Cardiology and Emergency Medicine, Wilhelminen Hospital, Montleartstrasse 37, 1160 Vienna, AustriaGender Medicine Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, AustriaGender Medicine Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, AustriaMetabolic Unit, Institute of Biomedical Engineering, National Research Council, Padova, ItalyMetabolic Unit, Institute of Biomedical Engineering, National Research Council, Padova, ItalyClinical Institute for Medical and Chemical Laboratory Diagnostic, General Hospital of Vienna, Vienna, AustriaDepartment of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria3rd Department of Medicine, Cardiology and Emergency Medicine, Wilhelminen Hospital, Montleartstrasse 37, 1160 Vienna, Austria3rd Department of Medicine, Cardiology and Emergency Medicine, Wilhelminen Hospital, Montleartstrasse 37, 1160 Vienna, AustriaGender Medicine Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, AustriaObjective. Fetuin-A has been associated with gestational diabetes mellitus (GDM). We investigated fetuin-A levels during and after pregnancy in women with GDM. Fetuin-A measurements were performed in 10 women with GDM and 10 age and body mass index (BMI) matched healthy pregnant women. All women underwent an oral glucose tolerance test (OGTT) in and 3 months after gestation. Results. Fasting fetuin-A correlated with BMI in women with former GDM (r=0.90, P<0.0001) but showed no association with parameters of glucose tolerance in women with GDM or post-GDM. GDM featured significantly lower insulin sensitivity and higher insulin and C-peptide secretion profiles compared to NGT during pregnancy (P<0.05). Fasting and postprandial fetuin-A did not differ between groups, neither during nor after pregnancy. Conclusion. Fetuin-A is not influenced by glucose tolerance during or after pregnancy or acute glucose elevations following glucose ingestion in young women, but closely relates to BMI early postpartum.http://dx.doi.org/10.1155/2012/896736 |
| spellingShingle | Serdar Farhan Ammon Handisurya Jelena Todoric Andrea Tura Giovanni Pacini Oswald Wagner Katharina Klein Rudolf Jarai Kurt Huber Alexandra Kautzky-Willer Fetuin-A Characteristics during and after Pregnancy: Result from a Case Control Pilot Study International Journal of Endocrinology |
| title | Fetuin-A Characteristics during and after Pregnancy: Result from a Case Control Pilot Study |
| title_full | Fetuin-A Characteristics during and after Pregnancy: Result from a Case Control Pilot Study |
| title_fullStr | Fetuin-A Characteristics during and after Pregnancy: Result from a Case Control Pilot Study |
| title_full_unstemmed | Fetuin-A Characteristics during and after Pregnancy: Result from a Case Control Pilot Study |
| title_short | Fetuin-A Characteristics during and after Pregnancy: Result from a Case Control Pilot Study |
| title_sort | fetuin a characteristics during and after pregnancy result from a case control pilot study |
| url | http://dx.doi.org/10.1155/2012/896736 |
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