Circulating Tumor DNA in a Breast Cancer Patient's Plasma Represents Driver Alterations in the Tumor Tissue

Circulating Tumor DNA in a Breast Cancer Patient's Plasma Represents Driver Alterations in the Tumor Tissue

Tumor tissues from biopsies or surgery are major sources for the next generation sequencing (NGS) study, but these procedures are invasive and have limitation to overcome intratumor heterogeneity. Recent studies have shown that driver alterations in tumor tissues can be detected by liquid biopsy whi...

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Bibliographic Details
Main Authors: Jieun Lee, Sung-Min Cho, Min Sung Kim, Sug Hyung Lee, Yeun-Jun Chung, Seung-Hyun Jung
Format: Article
Language:English
Published: BioMed Central 2017-03-01
Series:Genomics & Informatics
Subjects:
breast neoplasms
CDK4 amplification
circulating tumor DNA
liquid biopsy
next generation sequencing
PTEN mutation
Online Access:http://genominfo.org/upload/pdf/gni-15-48.pdf
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