Role of Ondansetron in Obsessive-Compulsive Disorder: A Systematic Review

Aims: In obsessive-compulsive disorder (OCD), treatment non-response is common with recommended medications; hence there is a need to investigate the role of alternative agents. It was intended to evaluate the evidence base involving ondansetron as a treatment strategy for OCD in adults, considering...

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Main Authors: Neelam Choudhary, Nilamadhab Kar
Format: Article
Language:English
Published: Cambridge University Press 2025-06-01
Series:BJPsych Open
Online Access:https://www.cambridge.org/core/product/identifier/S2056472425101130/type/journal_article
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author Neelam Choudhary
Nilamadhab Kar
author_facet Neelam Choudhary
Nilamadhab Kar
author_sort Neelam Choudhary
collection DOAJ
description Aims: In obsessive-compulsive disorder (OCD), treatment non-response is common with recommended medications; hence there is a need to investigate the role of alternative agents. It was intended to evaluate the evidence base involving ondansetron as a treatment strategy for OCD in adults, considering its role as a 5-HT3 receptor antagonist primarily in the limbic system.
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institution Kabale University
issn 2056-4724
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publisher Cambridge University Press
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series BJPsych Open
spelling doaj-art-92156e5dfbf242e7b48674dd678741ce2025-08-20T03:32:22ZengCambridge University PressBJPsych Open2056-47242025-06-0111S29S2910.1192/bjo.2025.10113Role of Ondansetron in Obsessive-Compulsive Disorder: A Systematic ReviewNeelam Choudhary0Nilamadhab Kar11Black Country Healthcare NHS Foundation Trust, Dudley, United Kingdom2Black Country Healthcare NHS Foundation Trust, Wolverhampton, United Kingdom 3University of Wolverhampton, Wolverhampton, United KingdomAims: In obsessive-compulsive disorder (OCD), treatment non-response is common with recommended medications; hence there is a need to investigate the role of alternative agents. It was intended to evaluate the evidence base involving ondansetron as a treatment strategy for OCD in adults, considering its role as a 5-HT3 receptor antagonist primarily in the limbic system.https://www.cambridge.org/core/product/identifier/S2056472425101130/type/journal_article
spellingShingle Neelam Choudhary
Nilamadhab Kar
Role of Ondansetron in Obsessive-Compulsive Disorder: A Systematic Review
BJPsych Open
title Role of Ondansetron in Obsessive-Compulsive Disorder: A Systematic Review
title_full Role of Ondansetron in Obsessive-Compulsive Disorder: A Systematic Review
title_fullStr Role of Ondansetron in Obsessive-Compulsive Disorder: A Systematic Review
title_full_unstemmed Role of Ondansetron in Obsessive-Compulsive Disorder: A Systematic Review
title_short Role of Ondansetron in Obsessive-Compulsive Disorder: A Systematic Review
title_sort role of ondansetron in obsessive compulsive disorder a systematic review
url https://www.cambridge.org/core/product/identifier/S2056472425101130/type/journal_article
work_keys_str_mv AT neelamchoudhary roleofondansetroninobsessivecompulsivedisorderasystematicreview
AT nilamadhabkar roleofondansetroninobsessivecompulsivedisorderasystematicreview