A Potent Inhibitor of Caspase‑8 Based on the IL-18 Tetrapeptide Sequence Reveals Shared Specificities between Inflammatory and Apoptotic Initiator Caspases
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| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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American Chemical Society
2025-07-01
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| Series: | ACS Bio & Med Chem Au |
| Online Access: | https://doi.org/10.1021/acsbiomedchemau.4c00146 |
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| author | Christopher M. Bourne Nicole R. Raniszewski Ashutosh B. Mahale Madhura Kulkarni Patrick M. Exconde Sherry Liu Winslow Yost Tristan J. Wrong Robert C. Patio Matilda Kardhashi Teni Shosanya Mirai Kambayashi Bohdana M. Discher Igor E. Brodsky George M. Burslem Cornelius Y. Taabazuing |
| author_facet | Christopher M. Bourne Nicole R. Raniszewski Ashutosh B. Mahale Madhura Kulkarni Patrick M. Exconde Sherry Liu Winslow Yost Tristan J. Wrong Robert C. Patio Matilda Kardhashi Teni Shosanya Mirai Kambayashi Bohdana M. Discher Igor E. Brodsky George M. Burslem Cornelius Y. Taabazuing |
| author_sort | Christopher M. Bourne |
| collection | DOAJ |
| format | Article |
| id | doaj-art-921153f3bb5d4619b7d538b45656db66 |
| institution | Kabale University |
| issn | 2694-2437 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | American Chemical Society |
| record_format | Article |
| series | ACS Bio & Med Chem Au |
| spelling | doaj-art-921153f3bb5d4619b7d538b45656db662025-08-20T07:32:45ZengAmerican Chemical SocietyACS Bio & Med Chem Au2694-24372025-07-015456558110.1021/acsbiomedchemau.4c00146A Potent Inhibitor of Caspase‑8 Based on the IL-18 Tetrapeptide Sequence Reveals Shared Specificities between Inflammatory and Apoptotic Initiator CaspasesChristopher M. Bourne0Nicole R. Raniszewski1Ashutosh B. Mahale2Madhura Kulkarni3Patrick M. Exconde4Sherry Liu5Winslow Yost6Tristan J. Wrong7Robert C. Patio8Matilda Kardhashi9Teni Shosanya10Mirai Kambayashi11Bohdana M. Discher12Igor E. Brodsky13George M. Burslem14Cornelius Y. Taabazuing15Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United StatesDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United StatesDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United StatesDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United StatesDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United StatesDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United StatesDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United StatesDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United StatesDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United StatesDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United StatesDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United StatesDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United StatesDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United StatesDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United StatesDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United StatesDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United Stateshttps://doi.org/10.1021/acsbiomedchemau.4c00146 |
| spellingShingle | Christopher M. Bourne Nicole R. Raniszewski Ashutosh B. Mahale Madhura Kulkarni Patrick M. Exconde Sherry Liu Winslow Yost Tristan J. Wrong Robert C. Patio Matilda Kardhashi Teni Shosanya Mirai Kambayashi Bohdana M. Discher Igor E. Brodsky George M. Burslem Cornelius Y. Taabazuing A Potent Inhibitor of Caspase‑8 Based on the IL-18 Tetrapeptide Sequence Reveals Shared Specificities between Inflammatory and Apoptotic Initiator Caspases ACS Bio & Med Chem Au |
| title | A Potent Inhibitor of Caspase‑8 Based on the IL-18 Tetrapeptide Sequence Reveals Shared Specificities between Inflammatory and Apoptotic Initiator Caspases |
| title_full | A Potent Inhibitor of Caspase‑8 Based on the IL-18 Tetrapeptide Sequence Reveals Shared Specificities between Inflammatory and Apoptotic Initiator Caspases |
| title_fullStr | A Potent Inhibitor of Caspase‑8 Based on the IL-18 Tetrapeptide Sequence Reveals Shared Specificities between Inflammatory and Apoptotic Initiator Caspases |
| title_full_unstemmed | A Potent Inhibitor of Caspase‑8 Based on the IL-18 Tetrapeptide Sequence Reveals Shared Specificities between Inflammatory and Apoptotic Initiator Caspases |
| title_short | A Potent Inhibitor of Caspase‑8 Based on the IL-18 Tetrapeptide Sequence Reveals Shared Specificities between Inflammatory and Apoptotic Initiator Caspases |
| title_sort | potent inhibitor of caspase 8 based on the il 18 tetrapeptide sequence reveals shared specificities between inflammatory and apoptotic initiator caspases |
| url | https://doi.org/10.1021/acsbiomedchemau.4c00146 |
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