Sero-epidemiology of measles immunoglobulin G antibodies among newborns from South-East Asia and sub-Saharan Africa: an observational, multicenter study
Objectives: To investigate the transplacental acquisition of measles immunoglobulin (Ig)G in newborns at delivery in Bangladesh, Bhutan, India, Ethiopia, Mozambique, Kenya, Nigeria, Mali, and South Africa. Methods: Archived cord serum, from a multicenter study on Group B Streptococcus, were tested f...
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2025-05-01
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| author | Carine Bokop Nisha Dhar Alane Izu Musa Mohammed Ali Godwin Akaba Hellen C. Barsosio James A Berkley Manisha Madhai Beck Tolossa E Chaka Clare L. Cutland Phurb Dorji Adama Mamby Keita Feleke Belachew Lema Nubwa Medugu Salim Mwarumba Stella Mwakio Stephen Obaro Eyinade K Olateju Rani Diana Sahni Samir K Saha Sridhar Santhanam Ragunath Sharma Betuel Sigaúque Eric A.F. Simoes Samba O Sow Milagritos D Tapia Balaji Veeraraghavan Shabir A Madhi Gaurav Kwatra |
| author_facet | Carine Bokop Nisha Dhar Alane Izu Musa Mohammed Ali Godwin Akaba Hellen C. Barsosio James A Berkley Manisha Madhai Beck Tolossa E Chaka Clare L. Cutland Phurb Dorji Adama Mamby Keita Feleke Belachew Lema Nubwa Medugu Salim Mwarumba Stella Mwakio Stephen Obaro Eyinade K Olateju Rani Diana Sahni Samir K Saha Sridhar Santhanam Ragunath Sharma Betuel Sigaúque Eric A.F. Simoes Samba O Sow Milagritos D Tapia Balaji Veeraraghavan Shabir A Madhi Gaurav Kwatra |
| author_sort | Carine Bokop |
| collection | DOAJ |
| description | Objectives: To investigate the transplacental acquisition of measles immunoglobulin (Ig)G in newborns at delivery in Bangladesh, Bhutan, India, Ethiopia, Mozambique, Kenya, Nigeria, Mali, and South Africa. Methods: Archived cord serum, from a multicenter study on Group B Streptococcus, were tested for measles IgG using a commercial enzyme link immunosorbent assay (ELISA). We tested 323 randomly selected samples from each of the sites. Models using various measles antibody decay rates in infancy were explored. Results: Overall, 2,907 cord serum samples were analyzed. At birth, 49.9% of newborns were measles IgG seronegative. Measles seronegativity ranged from 21.7% in Nigeria to 73.4% in Bhutan. The adjusted odds of seronegativity in infants of mothers born after measles vaccination implementation was 1.78 times that for infants born to unvaccinated mothers (adjusted odds ratio 1.78; 95% confidence interval 1.43-2.21; P <0.001). Modeling measles-IgG kinetics predicted that 70.8%, 88.3%, and 100% of infants would be seronegative by 2, 4, and 6 months, respectively, without further exposure. Conclusions: Our findings suggest low transplacental acquisition of measles IgG in newborns, which is likely to yield susceptibility to measles infection at a very young age. The currently recommended measles vaccine schedules in low- and middle-income countries (LMICs), with the first dose recommended from 9 months of age and onward, warrant reconsideration, including the need for earlier dosing schedules. |
| format | Article |
| id | doaj-art-920fe90f4add4a9fb195ef66f55d4f89 |
| institution | DOAJ |
| issn | 1201-9712 |
| language | English |
| publishDate | 2025-05-01 |
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| series | International Journal of Infectious Diseases |
| spelling | doaj-art-920fe90f4add4a9fb195ef66f55d4f892025-08-20T03:06:30ZengElsevierInternational Journal of Infectious Diseases1201-97122025-05-0115410788210.1016/j.ijid.2025.107882Sero-epidemiology of measles immunoglobulin G antibodies among newborns from South-East Asia and sub-Saharan Africa: an observational, multicenter studyCarine Bokop0Nisha Dhar1Alane Izu2Musa Mohammed Ali3Godwin Akaba4Hellen C. Barsosio5James A Berkley6Manisha Madhai Beck7Tolossa E Chaka8Clare L. Cutland9Phurb Dorji10Adama Mamby Keita11Feleke Belachew Lema12Nubwa Medugu13Salim Mwarumba14Stella Mwakio15Stephen Obaro16Eyinade K Olateju17Rani Diana Sahni18Samir K Saha19Sridhar Santhanam20Ragunath Sharma21Betuel Sigaúque22Eric A.F. Simoes23Samba O Sow24Milagritos D Tapia25Balaji Veeraraghavan26Shabir A Madhi27Gaurav Kwatra28South Africa Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Science, University of the Witwatersrand, Johannesburg, South AfricaSouth Africa Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Science, University of the Witwatersrand, Johannesburg, South AfricaSouth Africa Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Science, University of the Witwatersrand, Johannesburg, South AfricaHawassa University College of Medicine and Health Sciences, School of Medical Laboratory Sciences, Hawassa, EthiopiaDepartment of Obstetrics and Gynaecology, The University of Abuja Teaching Hospital, Abuja, NigeriaDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK; KEMRI/Welcome Trust Research Program, Kilifi, KenyaKEMRI/Welcome Trust Research Program, Kilifi, Kenya; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UKFetal Medicine Unit, Department of Obstetrics and Gynaecology, Christian Medical College, Vellore, IndiaDepartment of Pediatrics and Child Health, Adama Hospital Medical College, Adama City, EthiopiaAfrican Leadership in Vaccinology Expertise, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaJigme Dorji Wangchuck National Referral Hospital, Thimphu, BhutanLe Centre pour le Développement des Vaccins du Mali (CVD-Mali), Bamako, MaliOromiya Public Health Research Capacity Building and Quality Assurance Laboratory, Adama, EthiopiaInternational Foundation against Infectious Diseases in Nigeria, Abuja, Nigeria; Department of Medical Microbiology and Immunology, Nile University of Nigeria, Abuja, NigeriaKEMRI/Welcome Trust Research Program, Kilifi, KenyaKEMRI/Welcome Trust Research Program, Kilifi, KenyaInternational Foundation against Infectious Diseases in Nigeria, Abuja, Nigeria; Division of Pediatric Infectious Diseases, University of Alabama at Birmingham, USADepartment of Paediatrics, University of Abuja Teaching Hospital, Abuja, NigeriaDepartment of Clinical Microbiology, Christian Medical College, Vellore, IndiaChild Health Research Foundation, Dhaka, Bangladesh; Bangladesh Shishu Hospital and Institute, Dhaka, BangladeshDepartment of Neonatology, Christian Medical College, Vellore, IndiaJigme Dorji Wangchuck National Referral Hospital, Thimphu, BhutanCentro de Investigação em Saúde da Manhiça (CISM), Manhica, Mozambique.Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Colorado School of Public Health, Aurora, USALe Centre pour le Développement des Vaccins du Mali (CVD-Mali), Bamako, MaliCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, USADepartment of Clinical Microbiology, Christian Medical College, Vellore, IndiaSouth Africa Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Science, University of the Witwatersrand, Johannesburg, South Africa; African Leadership in Vaccinology Expertise, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Wits Infectious Diseases and Oncology Research Institute, Faculty of Health Science, University of the Witwatersrand Johannesburg, South AfricaSouth Africa Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Science, University of the Witwatersrand, Johannesburg, South Africa; Department of Clinical Microbiology, Christian Medical College, Vellore, India; Division of Infectious Diseases, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, USA; Corresponding author. (G. Kwatra); Tel.: +27 11 983 4263.Objectives: To investigate the transplacental acquisition of measles immunoglobulin (Ig)G in newborns at delivery in Bangladesh, Bhutan, India, Ethiopia, Mozambique, Kenya, Nigeria, Mali, and South Africa. Methods: Archived cord serum, from a multicenter study on Group B Streptococcus, were tested for measles IgG using a commercial enzyme link immunosorbent assay (ELISA). We tested 323 randomly selected samples from each of the sites. Models using various measles antibody decay rates in infancy were explored. Results: Overall, 2,907 cord serum samples were analyzed. At birth, 49.9% of newborns were measles IgG seronegative. Measles seronegativity ranged from 21.7% in Nigeria to 73.4% in Bhutan. The adjusted odds of seronegativity in infants of mothers born after measles vaccination implementation was 1.78 times that for infants born to unvaccinated mothers (adjusted odds ratio 1.78; 95% confidence interval 1.43-2.21; P <0.001). Modeling measles-IgG kinetics predicted that 70.8%, 88.3%, and 100% of infants would be seronegative by 2, 4, and 6 months, respectively, without further exposure. Conclusions: Our findings suggest low transplacental acquisition of measles IgG in newborns, which is likely to yield susceptibility to measles infection at a very young age. The currently recommended measles vaccine schedules in low- and middle-income countries (LMICs), with the first dose recommended from 9 months of age and onward, warrant reconsideration, including the need for earlier dosing schedules.http://www.sciencedirect.com/science/article/pii/S1201971225001055Sero-prevalenceMeaslesPassive immunityAntibody decay |
| spellingShingle | Carine Bokop Nisha Dhar Alane Izu Musa Mohammed Ali Godwin Akaba Hellen C. Barsosio James A Berkley Manisha Madhai Beck Tolossa E Chaka Clare L. Cutland Phurb Dorji Adama Mamby Keita Feleke Belachew Lema Nubwa Medugu Salim Mwarumba Stella Mwakio Stephen Obaro Eyinade K Olateju Rani Diana Sahni Samir K Saha Sridhar Santhanam Ragunath Sharma Betuel Sigaúque Eric A.F. Simoes Samba O Sow Milagritos D Tapia Balaji Veeraraghavan Shabir A Madhi Gaurav Kwatra Sero-epidemiology of measles immunoglobulin G antibodies among newborns from South-East Asia and sub-Saharan Africa: an observational, multicenter study International Journal of Infectious Diseases Sero-prevalence Measles Passive immunity Antibody decay |
| title | Sero-epidemiology of measles immunoglobulin G antibodies among newborns from South-East Asia and sub-Saharan Africa: an observational, multicenter study |
| title_full | Sero-epidemiology of measles immunoglobulin G antibodies among newborns from South-East Asia and sub-Saharan Africa: an observational, multicenter study |
| title_fullStr | Sero-epidemiology of measles immunoglobulin G antibodies among newborns from South-East Asia and sub-Saharan Africa: an observational, multicenter study |
| title_full_unstemmed | Sero-epidemiology of measles immunoglobulin G antibodies among newborns from South-East Asia and sub-Saharan Africa: an observational, multicenter study |
| title_short | Sero-epidemiology of measles immunoglobulin G antibodies among newborns from South-East Asia and sub-Saharan Africa: an observational, multicenter study |
| title_sort | sero epidemiology of measles immunoglobulin g antibodies among newborns from south east asia and sub saharan africa an observational multicenter study |
| topic | Sero-prevalence Measles Passive immunity Antibody decay |
| url | http://www.sciencedirect.com/science/article/pii/S1201971225001055 |
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