Evaluation of the IMPROVE-DD score in COVID-19 patients submitted to venous thromboembolism investigation at a hospital in Brazil
ABSTRACT Objectives: To evaluate the incidence of venous thromboembolism (VTE) in hospitalized patients with COVID-19 who underwent diagnostic tests for suspected VTE, and to correlate the IMPROVE-DD score with the incidence of VTE in this cohort. Methods: This retrospective study included consecu...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Pneumologia e Tisiologia
2025-03-01
|
| Series: | Jornal Brasileiro de Pneumologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132025000100600&lng=en&tlng=en |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850152326657998848 |
|---|---|
| author | Ronney Argolo Ferreira Lian Zanatta Juliane Bispo de Oliveira Janaina Ibele Carvalho Gomes Luiz Ritt Ana Thereza Cavalcanti Rocha |
| author_facet | Ronney Argolo Ferreira Lian Zanatta Juliane Bispo de Oliveira Janaina Ibele Carvalho Gomes Luiz Ritt Ana Thereza Cavalcanti Rocha |
| author_sort | Ronney Argolo Ferreira |
| collection | DOAJ |
| description | ABSTRACT Objectives: To evaluate the incidence of venous thromboembolism (VTE) in hospitalized patients with COVID-19 who underwent diagnostic tests for suspected VTE, and to correlate the IMPROVE-DD score with the incidence of VTE in this cohort. Methods: This retrospective study included consecutive patients with COVID-19 and suspected VTE, admitted between March 2020 and September 2021 at a private hospital in Salvador (BA), Brazil, who underwent lower or upper limb venous Doppler ultrasound or chest angiotomography. Descriptive analyses and comparisons using the chi-square test were performed to identify factors potentially associated with the risk of VTE. Results: A total of 517 patients were included, with an in-hospital VTE incidence of 18.6% (96 events). Risk factors significantly associated with VTE included obesity, ICU admission, central venous catheter use, longer hospital stays, greater lung tomographic involvement/severity, the need for mechanical ventilation, D-dimer levels at least twice the upper limit of normal (2xULN), and the IMPROVE-DD score. The mean IMPROVE-DD score among patients with VTE was 4.7 (±3) versus 3.3 (±2.4) in those without VTE (p < 0.0001). D-dimer 2xULN was sensitive in identifying 94% of the 96 patients with VTE (p < 0.0001). The in-hospital mortality rate was 14.1%, with higher rates observed in patients with VTE (24%) compared to those without VTE (11.9%) (p = 0.003). Conclusions: The incidence of VTE in hospitalized COVID-19 patients was high and correlated with increased mortality. The IMPROVE-DD score effectively identified patients at risk for in-hospital VTE, suggesting it could help to identify a high-risk subgroup that may benefit from extended thromboprophylaxis. |
| format | Article |
| id | doaj-art-920df9cb1006404eae15565d402ea503 |
| institution | OA Journals |
| issn | 1806-3756 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Sociedade Brasileira de Pneumologia e Tisiologia |
| record_format | Article |
| series | Jornal Brasileiro de Pneumologia |
| spelling | doaj-art-920df9cb1006404eae15565d402ea5032025-08-20T02:26:01ZengSociedade Brasileira de Pneumologia e TisiologiaJornal Brasileiro de Pneumologia1806-37562025-03-0151110.36416/1806-3756/e20240042Evaluation of the IMPROVE-DD score in COVID-19 patients submitted to venous thromboembolism investigation at a hospital in BrazilRonney Argolo Ferreirahttps://orcid.org/0000-0001-6619-2402Lian Zanattahttps://orcid.org/0000-0003-0290-9157Juliane Bispo de Oliveirahttps://orcid.org/0000-0003-4129-3324Janaina Ibele Carvalho Gomeshttps://orcid.org/0000-0002-1988-0699Luiz Ritthttps://orcid.org/0000-0001-9320-7999Ana Thereza Cavalcanti Rochahttps://orcid.org/0000-0002-5321-2598ABSTRACT Objectives: To evaluate the incidence of venous thromboembolism (VTE) in hospitalized patients with COVID-19 who underwent diagnostic tests for suspected VTE, and to correlate the IMPROVE-DD score with the incidence of VTE in this cohort. Methods: This retrospective study included consecutive patients with COVID-19 and suspected VTE, admitted between March 2020 and September 2021 at a private hospital in Salvador (BA), Brazil, who underwent lower or upper limb venous Doppler ultrasound or chest angiotomography. Descriptive analyses and comparisons using the chi-square test were performed to identify factors potentially associated with the risk of VTE. Results: A total of 517 patients were included, with an in-hospital VTE incidence of 18.6% (96 events). Risk factors significantly associated with VTE included obesity, ICU admission, central venous catheter use, longer hospital stays, greater lung tomographic involvement/severity, the need for mechanical ventilation, D-dimer levels at least twice the upper limit of normal (2xULN), and the IMPROVE-DD score. The mean IMPROVE-DD score among patients with VTE was 4.7 (±3) versus 3.3 (±2.4) in those without VTE (p < 0.0001). D-dimer 2xULN was sensitive in identifying 94% of the 96 patients with VTE (p < 0.0001). The in-hospital mortality rate was 14.1%, with higher rates observed in patients with VTE (24%) compared to those without VTE (11.9%) (p = 0.003). Conclusions: The incidence of VTE in hospitalized COVID-19 patients was high and correlated with increased mortality. The IMPROVE-DD score effectively identified patients at risk for in-hospital VTE, suggesting it could help to identify a high-risk subgroup that may benefit from extended thromboprophylaxis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132025000100600&lng=en&tlng=enVenous thromboembolismCOVID-19IMPROVE-DD |
| spellingShingle | Ronney Argolo Ferreira Lian Zanatta Juliane Bispo de Oliveira Janaina Ibele Carvalho Gomes Luiz Ritt Ana Thereza Cavalcanti Rocha Evaluation of the IMPROVE-DD score in COVID-19 patients submitted to venous thromboembolism investigation at a hospital in Brazil Jornal Brasileiro de Pneumologia Venous thromboembolism COVID-19 IMPROVE-DD |
| title | Evaluation of the IMPROVE-DD score in COVID-19 patients submitted to venous thromboembolism investigation at a hospital in Brazil |
| title_full | Evaluation of the IMPROVE-DD score in COVID-19 patients submitted to venous thromboembolism investigation at a hospital in Brazil |
| title_fullStr | Evaluation of the IMPROVE-DD score in COVID-19 patients submitted to venous thromboembolism investigation at a hospital in Brazil |
| title_full_unstemmed | Evaluation of the IMPROVE-DD score in COVID-19 patients submitted to venous thromboembolism investigation at a hospital in Brazil |
| title_short | Evaluation of the IMPROVE-DD score in COVID-19 patients submitted to venous thromboembolism investigation at a hospital in Brazil |
| title_sort | evaluation of the improve dd score in covid 19 patients submitted to venous thromboembolism investigation at a hospital in brazil |
| topic | Venous thromboembolism COVID-19 IMPROVE-DD |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132025000100600&lng=en&tlng=en |
| work_keys_str_mv | AT ronneyargoloferreira evaluationoftheimproveddscoreincovid19patientssubmittedtovenousthromboembolisminvestigationatahospitalinbrazil AT lianzanatta evaluationoftheimproveddscoreincovid19patientssubmittedtovenousthromboembolisminvestigationatahospitalinbrazil AT julianebispodeoliveira evaluationoftheimproveddscoreincovid19patientssubmittedtovenousthromboembolisminvestigationatahospitalinbrazil AT janainaibelecarvalhogomes evaluationoftheimproveddscoreincovid19patientssubmittedtovenousthromboembolisminvestigationatahospitalinbrazil AT luizritt evaluationoftheimproveddscoreincovid19patientssubmittedtovenousthromboembolisminvestigationatahospitalinbrazil AT anatherezacavalcantirocha evaluationoftheimproveddscoreincovid19patientssubmittedtovenousthromboembolisminvestigationatahospitalinbrazil |