Local sympathetic nerve depletion does not alter vitiligo progression in a mouse model
Vitiligo, an autoimmune skin disorder characterized by melanocyte loss, has long been associated with sympathetic nervous system activity. Clinical observations have suggested links between psychological stress, sympathetic activation, and vitiligo progression. However, direct experimental evidence...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1466996/full |
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| author | Zhichao Hu Zhichao Hu Ting Chen Ting Chen Ting Chen Daoming Chen |
| author_facet | Zhichao Hu Zhichao Hu Ting Chen Ting Chen Ting Chen Daoming Chen |
| author_sort | Zhichao Hu |
| collection | DOAJ |
| description | Vitiligo, an autoimmune skin disorder characterized by melanocyte loss, has long been associated with sympathetic nervous system activity. Clinical observations have suggested links between psychological stress, sympathetic activation, and vitiligo progression. However, direct experimental evidence for the role of sympathetic nerves in vitiligo development has been lacking. Herein, we employed 6-hydroxydopamine (6-OHDA) to induce sympathetic nerve depletion in mice before vitiligo induction. Sympathetic nerve ablation was confirmed through immunofluorescent staining of tyrosine hydroxylase. Vitiligo progression was assessed by quantifying epidermal melanocytes and CD8+ T cells using whole-mount immunofluorescence staining. The loss of melanocytes and infiltration of CD8+ T cells in vitiligo lesions were comparable between sympathectomized and control mice. Overall, our study suggested that previously observed associations between sympathetic nervous system activity and vitiligo may be concomitant effects rather than causative factors, challenging long-held clinical hypotheses. |
| format | Article |
| id | doaj-art-920d080beceb4795af1afd2a7ebdb228 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-920d080beceb4795af1afd2a7ebdb2282025-01-31T05:10:15ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011210.3389/fmed.2025.14669961466996Local sympathetic nerve depletion does not alter vitiligo progression in a mouse modelZhichao Hu0Zhichao Hu1Ting Chen2Ting Chen3Ting Chen4Daoming Chen5Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, ChinaNational Institute of Biological Sciences, Beijing, ChinaGraduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, ChinaNational Institute of Biological Sciences, Beijing, ChinaTsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, ChinaNational Institute of Biological Sciences, Beijing, ChinaVitiligo, an autoimmune skin disorder characterized by melanocyte loss, has long been associated with sympathetic nervous system activity. Clinical observations have suggested links between psychological stress, sympathetic activation, and vitiligo progression. However, direct experimental evidence for the role of sympathetic nerves in vitiligo development has been lacking. Herein, we employed 6-hydroxydopamine (6-OHDA) to induce sympathetic nerve depletion in mice before vitiligo induction. Sympathetic nerve ablation was confirmed through immunofluorescent staining of tyrosine hydroxylase. Vitiligo progression was assessed by quantifying epidermal melanocytes and CD8+ T cells using whole-mount immunofluorescence staining. The loss of melanocytes and infiltration of CD8+ T cells in vitiligo lesions were comparable between sympathectomized and control mice. Overall, our study suggested that previously observed associations between sympathetic nervous system activity and vitiligo may be concomitant effects rather than causative factors, challenging long-held clinical hypotheses.https://www.frontiersin.org/articles/10.3389/fmed.2025.1466996/fullautoimmune diseaseskin diseasevitiligosympathetic nervemelanocyteCD8+ T cell |
| spellingShingle | Zhichao Hu Zhichao Hu Ting Chen Ting Chen Ting Chen Daoming Chen Local sympathetic nerve depletion does not alter vitiligo progression in a mouse model Frontiers in Medicine autoimmune disease skin disease vitiligo sympathetic nerve melanocyte CD8+ T cell |
| title | Local sympathetic nerve depletion does not alter vitiligo progression in a mouse model |
| title_full | Local sympathetic nerve depletion does not alter vitiligo progression in a mouse model |
| title_fullStr | Local sympathetic nerve depletion does not alter vitiligo progression in a mouse model |
| title_full_unstemmed | Local sympathetic nerve depletion does not alter vitiligo progression in a mouse model |
| title_short | Local sympathetic nerve depletion does not alter vitiligo progression in a mouse model |
| title_sort | local sympathetic nerve depletion does not alter vitiligo progression in a mouse model |
| topic | autoimmune disease skin disease vitiligo sympathetic nerve melanocyte CD8+ T cell |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1466996/full |
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