Change in the Activity of Acidic and Alkaline Phosphatases in Immunocompetent Organs -a Criterion for Evaluating the Effectiveness of Immunobiological Preparations
Dynamics of acidic and alkaline phosphatase activities was examined in thymus and spleen of laboratory mice immunized by cell wall preparations of Francisella tularensis of different subspecies. Cell wall preparations of two subspecies: F. tularensis subsp. mediaasiatica А-61(385) and F. tularensis...
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| Format: | Article |
| Language: | Russian |
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Numikom LLC
2017-06-01
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| Series: | Эпидемиология и вакцинопрофилактика |
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| Online Access: | https://www.epidemvac.ru/jour/article/view/282 |
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| author | O. V. Yurieva V. I. Dubrovina A. V. Korneva T. P. Starovoitova T. A. Ivanova V. B. Nikolaev S. V. Balakhonov |
| author_facet | O. V. Yurieva V. I. Dubrovina A. V. Korneva T. P. Starovoitova T. A. Ivanova V. B. Nikolaev S. V. Balakhonov |
| author_sort | O. V. Yurieva |
| collection | DOAJ |
| description | Dynamics of acidic and alkaline phosphatase activities was examined in thymus and spleen of laboratory mice immunized by cell wall preparations of Francisella tularensis of different subspecies. Cell wall preparations of two subspecies: F. tularensis subsp. mediaasiatica А-61(385) and F. tularensis subsp. novicida В-399 A-Cole (386) stimulated the rise of acidic and alkaline phosphatase activities in earlier time (7 days) after immunization than the others. It was correlated with their protective activity. On the basis of the results it is concluded that the studying of the acidic and alkaline phosphatase activities in immunocompetent organs can serve as one of the criteria for evaluation of efficiency of immunobiological preparations. |
| format | Article |
| id | doaj-art-9200d29d112e4413afbd3d68266ebceb |
| institution | DOAJ |
| issn | 2073-3046 2619-0494 |
| language | Russian |
| publishDate | 2017-06-01 |
| publisher | Numikom LLC |
| record_format | Article |
| series | Эпидемиология и вакцинопрофилактика |
| spelling | doaj-art-9200d29d112e4413afbd3d68266ebceb2025-08-20T03:00:50ZrusNumikom LLCЭпидемиология и вакцинопрофилактика2073-30462619-04942017-06-01163848810.31631/2073-3046-2017-16-3-84-88281Change in the Activity of Acidic and Alkaline Phosphatases in Immunocompetent Organs -a Criterion for Evaluating the Effectiveness of Immunobiological PreparationsO. V. Yurieva0V. I. Dubrovina1A. V. Korneva2T. P. Starovoitova3T. A. Ivanova4V. B. Nikolaev5S. V. Balakhonov6Federal Budgetary Healthcare Facility «Irkutsk Antiplague Research Institute» of Federal Service for Surveillance on Consumer RightsFederal Budgetary Healthcare Facility «Irkutsk Antiplague Research Institute» of Federal Service for Surveillance on Consumer RightsFederal Budgetary Healthcare Facility «Irkutsk Antiplague Research Institute» of Federal Service for Surveillance on Consumer RightsFederal Budgetary Healthcare Facility «Irkutsk Antiplague Research Institute» of Federal Service for Surveillance on Consumer RightsFederal Budgetary Healthcare Facility «Irkutsk Antiplague Research Institute» of Federal Service for Surveillance on Consumer RightsFederal Budgetary Healthcare Facility «Irkutsk Antiplague Research Institute» of Federal Service for Surveillance on Consumer RightsFederal Budgetary Healthcare Facility «Irkutsk Antiplague Research Institute» of Federal Service for Surveillance on Consumer RightsDynamics of acidic and alkaline phosphatase activities was examined in thymus and spleen of laboratory mice immunized by cell wall preparations of Francisella tularensis of different subspecies. Cell wall preparations of two subspecies: F. tularensis subsp. mediaasiatica А-61(385) and F. tularensis subsp. novicida В-399 A-Cole (386) stimulated the rise of acidic and alkaline phosphatase activities in earlier time (7 days) after immunization than the others. It was correlated with their protective activity. On the basis of the results it is concluded that the studying of the acidic and alkaline phosphatase activities in immunocompetent organs can serve as one of the criteria for evaluation of efficiency of immunobiological preparations.https://www.epidemvac.ru/jour/article/view/282туляремияклеточная стенкафосфатазатимусселезенкаfrancisella tularensiscell wallphosphatasethymusspleen |
| spellingShingle | O. V. Yurieva V. I. Dubrovina A. V. Korneva T. P. Starovoitova T. A. Ivanova V. B. Nikolaev S. V. Balakhonov Change in the Activity of Acidic and Alkaline Phosphatases in Immunocompetent Organs -a Criterion for Evaluating the Effectiveness of Immunobiological Preparations Эпидемиология и вакцинопрофилактика туляремия клеточная стенка фосфатаза тимус селезенка francisella tularensis cell wall phosphatase thymus spleen |
| title | Change in the Activity of Acidic and Alkaline Phosphatases in Immunocompetent Organs -a Criterion for Evaluating the Effectiveness of Immunobiological Preparations |
| title_full | Change in the Activity of Acidic and Alkaline Phosphatases in Immunocompetent Organs -a Criterion for Evaluating the Effectiveness of Immunobiological Preparations |
| title_fullStr | Change in the Activity of Acidic and Alkaline Phosphatases in Immunocompetent Organs -a Criterion for Evaluating the Effectiveness of Immunobiological Preparations |
| title_full_unstemmed | Change in the Activity of Acidic and Alkaline Phosphatases in Immunocompetent Organs -a Criterion for Evaluating the Effectiveness of Immunobiological Preparations |
| title_short | Change in the Activity of Acidic and Alkaline Phosphatases in Immunocompetent Organs -a Criterion for Evaluating the Effectiveness of Immunobiological Preparations |
| title_sort | change in the activity of acidic and alkaline phosphatases in immunocompetent organs a criterion for evaluating the effectiveness of immunobiological preparations |
| topic | туляремия клеточная стенка фосфатаза тимус селезенка francisella tularensis cell wall phosphatase thymus spleen |
| url | https://www.epidemvac.ru/jour/article/view/282 |
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