Beyond ADME: The Endogenous Functions of Drug Transporters and Its Impact on Human Disease
Drug transporters are crucial for facilitating the distribution and elimination of drugs from the body, yet their broader physiological functions remain underexplored. Beyond drug handling, these transporters regulate key biological processes, including barrier integrity, metabolic homeostasis, deto...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/17/6/685 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849431291072610304 |
|---|---|
| author | Christine Blaze Yan Shu |
| author_facet | Christine Blaze Yan Shu |
| author_sort | Christine Blaze |
| collection | DOAJ |
| description | Drug transporters are crucial for facilitating the distribution and elimination of drugs from the body, yet their broader physiological functions remain underexplored. Beyond drug handling, these transporters regulate key biological processes, including barrier integrity, metabolic homeostasis, detoxification, and immune response. Here we examine the endogenous roles of representative drug transporters along with their involvement in disease pathophysiology, particularly in neurological disorders, cancer, metabolic syndromes, kidney disease, and hepatic disorders. Given the complex interplay between transporters and various physiological processes, a comprehensive understanding of their roles beyond drug transport is imperative for advancing therapeutic strategies and fully grasping their impact on human health. By elucidating their mechanistic roles, researchers can refine drug development and identify novel therapeutic targets. This review underscores the need for continued research into transporters’ diverse functions and their potential as key modulators in disease prevention and treatment. |
| format | Article |
| id | doaj-art-91ffed53ac734753bdc991df035a53db |
| institution | Kabale University |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-91ffed53ac734753bdc991df035a53db2025-08-20T03:27:41ZengMDPI AGPharmaceutics1999-49232025-05-0117668510.3390/pharmaceutics17060685Beyond ADME: The Endogenous Functions of Drug Transporters and Its Impact on Human DiseaseChristine Blaze0Yan Shu1Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USADepartment of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USADrug transporters are crucial for facilitating the distribution and elimination of drugs from the body, yet their broader physiological functions remain underexplored. Beyond drug handling, these transporters regulate key biological processes, including barrier integrity, metabolic homeostasis, detoxification, and immune response. Here we examine the endogenous roles of representative drug transporters along with their involvement in disease pathophysiology, particularly in neurological disorders, cancer, metabolic syndromes, kidney disease, and hepatic disorders. Given the complex interplay between transporters and various physiological processes, a comprehensive understanding of their roles beyond drug transport is imperative for advancing therapeutic strategies and fully grasping their impact on human health. By elucidating their mechanistic roles, researchers can refine drug development and identify novel therapeutic targets. This review underscores the need for continued research into transporters’ diverse functions and their potential as key modulators in disease prevention and treatment.https://www.mdpi.com/1999-4923/17/6/685drug transportersendogenous substratesendogenous functiontransporter-mediated pathophysiologydetoxificationimmune modulation |
| spellingShingle | Christine Blaze Yan Shu Beyond ADME: The Endogenous Functions of Drug Transporters and Its Impact on Human Disease Pharmaceutics drug transporters endogenous substrates endogenous function transporter-mediated pathophysiology detoxification immune modulation |
| title | Beyond ADME: The Endogenous Functions of Drug Transporters and Its Impact on Human Disease |
| title_full | Beyond ADME: The Endogenous Functions of Drug Transporters and Its Impact on Human Disease |
| title_fullStr | Beyond ADME: The Endogenous Functions of Drug Transporters and Its Impact on Human Disease |
| title_full_unstemmed | Beyond ADME: The Endogenous Functions of Drug Transporters and Its Impact on Human Disease |
| title_short | Beyond ADME: The Endogenous Functions of Drug Transporters and Its Impact on Human Disease |
| title_sort | beyond adme the endogenous functions of drug transporters and its impact on human disease |
| topic | drug transporters endogenous substrates endogenous function transporter-mediated pathophysiology detoxification immune modulation |
| url | https://www.mdpi.com/1999-4923/17/6/685 |
| work_keys_str_mv | AT christineblaze beyondadmetheendogenousfunctionsofdrugtransportersanditsimpactonhumandisease AT yanshu beyondadmetheendogenousfunctionsofdrugtransportersanditsimpactonhumandisease |