Corneal oxidative stress, inflammation, and senescence as key drivers of ocular pathology in a chronic graft-versus-host disease model

Corneal oxidative stress, inflammation, and senescence as key drivers of ocular pathology in a chronic graft-versus-host disease model

Abstract Background Chronic graft-versus-host disease (cGVHD) is a severe complication of allogeneic hematopoietic stem cell transplantation, frequently associated with severe dry eye syndrome. Using a murine cGVHD model, this study investigates the roles of oxidative stress, inflammation, and cellu...

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Bibliographic Details
Main Authors: Rong Wu, Shuwan Liu, Zhan Shen, Yinghan Zhao, Jing Hong, Jiao Ma
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Ophthalmology
Subjects:
Chronic graft-versus-host disease
Dry eye
Oxidative stress
Cellular senescence
Corneal pathology
Nrf2
Online Access:https://doi.org/10.1186/s12886-025-04210-9
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