The Type 2 Deiodinase Thr92Ala Polymorphism Is Associated with Worse Glycemic Control in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
Objective. Type 2 deiodinase (Dio2) is an enzyme responsible for the conversion of T4 to T3. The Thr92Ala polymorphism has been shown related to an increased risk for developing type 2 diabetes mellitus (T2DM). The aim of this study is to assess the association between this polymorphism and glycemic...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/5928726 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850209269831434240 |
|---|---|
| author | Xiaowen Zhang Jie Sun Wenqing Han Yaqiu Jiang Shiqiao Peng Zhongyan Shan Weiping Teng |
| author_facet | Xiaowen Zhang Jie Sun Wenqing Han Yaqiu Jiang Shiqiao Peng Zhongyan Shan Weiping Teng |
| author_sort | Xiaowen Zhang |
| collection | DOAJ |
| description | Objective. Type 2 deiodinase (Dio2) is an enzyme responsible for the conversion of T4 to T3. The Thr92Ala polymorphism has been shown related to an increased risk for developing type 2 diabetes mellitus (T2DM). The aim of this study is to assess the association between this polymorphism and glycemic control in T2DM patients as marked by the HbA1C levels. Design and Methods. The terms “rs225014,” “thr92ala,” “T92A,” or “dio2 a/g” were used to search for eligible studies in the PubMed, Embase, and Cochrane databases and Google Scholar. A systematic review and meta-analysis of studies including both polymorphism testing and glycated hemoglobin (HbA1C) assays were performed. Results. Four studies were selected, totaling 2190 subjects. The pooled mean difference of the studies was 0.48% (95% CI, 0.18–0.77%), indicating that type 2 diabetics homozygous for the Dio2 Thr92Ala polymorphism had higher HbA1C levels. Conclusions. Homozygosity for the Dio2 Thr92Ala polymorphism is associated with higher HbA1C levels in T2DM patients. To confirm this conclusion, more studies of larger populations are needed. |
| format | Article |
| id | doaj-art-91fa7516ea414122b9947cd01ba248ca |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-91fa7516ea414122b9947cd01ba248ca2025-08-20T02:10:02ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/59287265928726The Type 2 Deiodinase Thr92Ala Polymorphism Is Associated with Worse Glycemic Control in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-AnalysisXiaowen Zhang0Jie Sun1Wenqing Han2Yaqiu Jiang3Shiqiao Peng4Zhongyan Shan5Weiping Teng6The Endocrine Institute and The Liaoning Provincial Key Laboratory of Endocrine Diseases, Department of Endocrinology and Metabolism, The First Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang, Liaoning, ChinaThe Endocrine Institute and The Liaoning Provincial Key Laboratory of Endocrine Diseases, Department of Endocrinology and Metabolism, The First Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang, Liaoning, ChinaThe Endocrine Institute and The Liaoning Provincial Key Laboratory of Endocrine Diseases, Department of Endocrinology and Metabolism, The First Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang, Liaoning, ChinaThe Endocrine Institute and The Liaoning Provincial Key Laboratory of Endocrine Diseases, Department of Endocrinology and Metabolism, The First Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang, Liaoning, ChinaThe Endocrine Institute and The Liaoning Provincial Key Laboratory of Endocrine Diseases, Department of Endocrinology and Metabolism, The First Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang, Liaoning, ChinaThe Endocrine Institute and The Liaoning Provincial Key Laboratory of Endocrine Diseases, Department of Endocrinology and Metabolism, The First Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang, Liaoning, ChinaThe Endocrine Institute and The Liaoning Provincial Key Laboratory of Endocrine Diseases, Department of Endocrinology and Metabolism, The First Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang, Liaoning, ChinaObjective. Type 2 deiodinase (Dio2) is an enzyme responsible for the conversion of T4 to T3. The Thr92Ala polymorphism has been shown related to an increased risk for developing type 2 diabetes mellitus (T2DM). The aim of this study is to assess the association between this polymorphism and glycemic control in T2DM patients as marked by the HbA1C levels. Design and Methods. The terms “rs225014,” “thr92ala,” “T92A,” or “dio2 a/g” were used to search for eligible studies in the PubMed, Embase, and Cochrane databases and Google Scholar. A systematic review and meta-analysis of studies including both polymorphism testing and glycated hemoglobin (HbA1C) assays were performed. Results. Four studies were selected, totaling 2190 subjects. The pooled mean difference of the studies was 0.48% (95% CI, 0.18–0.77%), indicating that type 2 diabetics homozygous for the Dio2 Thr92Ala polymorphism had higher HbA1C levels. Conclusions. Homozygosity for the Dio2 Thr92Ala polymorphism is associated with higher HbA1C levels in T2DM patients. To confirm this conclusion, more studies of larger populations are needed.http://dx.doi.org/10.1155/2016/5928726 |
| spellingShingle | Xiaowen Zhang Jie Sun Wenqing Han Yaqiu Jiang Shiqiao Peng Zhongyan Shan Weiping Teng The Type 2 Deiodinase Thr92Ala Polymorphism Is Associated with Worse Glycemic Control in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis Journal of Diabetes Research |
| title | The Type 2 Deiodinase Thr92Ala Polymorphism Is Associated with Worse Glycemic Control in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis |
| title_full | The Type 2 Deiodinase Thr92Ala Polymorphism Is Associated with Worse Glycemic Control in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis |
| title_fullStr | The Type 2 Deiodinase Thr92Ala Polymorphism Is Associated with Worse Glycemic Control in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | The Type 2 Deiodinase Thr92Ala Polymorphism Is Associated with Worse Glycemic Control in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis |
| title_short | The Type 2 Deiodinase Thr92Ala Polymorphism Is Associated with Worse Glycemic Control in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis |
| title_sort | type 2 deiodinase thr92ala polymorphism is associated with worse glycemic control in patients with type 2 diabetes mellitus a systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2016/5928726 |
| work_keys_str_mv | AT xiaowenzhang thetype2deiodinasethr92alapolymorphismisassociatedwithworseglycemiccontrolinpatientswithtype2diabetesmellitusasystematicreviewandmetaanalysis AT jiesun thetype2deiodinasethr92alapolymorphismisassociatedwithworseglycemiccontrolinpatientswithtype2diabetesmellitusasystematicreviewandmetaanalysis AT wenqinghan thetype2deiodinasethr92alapolymorphismisassociatedwithworseglycemiccontrolinpatientswithtype2diabetesmellitusasystematicreviewandmetaanalysis AT yaqiujiang thetype2deiodinasethr92alapolymorphismisassociatedwithworseglycemiccontrolinpatientswithtype2diabetesmellitusasystematicreviewandmetaanalysis AT shiqiaopeng thetype2deiodinasethr92alapolymorphismisassociatedwithworseglycemiccontrolinpatientswithtype2diabetesmellitusasystematicreviewandmetaanalysis AT zhongyanshan thetype2deiodinasethr92alapolymorphismisassociatedwithworseglycemiccontrolinpatientswithtype2diabetesmellitusasystematicreviewandmetaanalysis AT weipingteng thetype2deiodinasethr92alapolymorphismisassociatedwithworseglycemiccontrolinpatientswithtype2diabetesmellitusasystematicreviewandmetaanalysis AT xiaowenzhang type2deiodinasethr92alapolymorphismisassociatedwithworseglycemiccontrolinpatientswithtype2diabetesmellitusasystematicreviewandmetaanalysis AT jiesun type2deiodinasethr92alapolymorphismisassociatedwithworseglycemiccontrolinpatientswithtype2diabetesmellitusasystematicreviewandmetaanalysis AT wenqinghan type2deiodinasethr92alapolymorphismisassociatedwithworseglycemiccontrolinpatientswithtype2diabetesmellitusasystematicreviewandmetaanalysis AT yaqiujiang type2deiodinasethr92alapolymorphismisassociatedwithworseglycemiccontrolinpatientswithtype2diabetesmellitusasystematicreviewandmetaanalysis AT shiqiaopeng type2deiodinasethr92alapolymorphismisassociatedwithworseglycemiccontrolinpatientswithtype2diabetesmellitusasystematicreviewandmetaanalysis AT zhongyanshan type2deiodinasethr92alapolymorphismisassociatedwithworseglycemiccontrolinpatientswithtype2diabetesmellitusasystematicreviewandmetaanalysis AT weipingteng type2deiodinasethr92alapolymorphismisassociatedwithworseglycemiccontrolinpatientswithtype2diabetesmellitusasystematicreviewandmetaanalysis |