Increased frontoparietal activity related to lower performance in neuropsychological assessment of working memory
Executive functions, including working memory, are typically assessed clinically with neuropsychological instruments. In contrast, computerized tasks are used to test these cognitive functions in laboratory human and animal studies. Little is known of how neural activity captured by laboratory tasks...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811925002435 |
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| author | August Jurva Balbir Singh Helen Qian Zhengyang Wang Monica L. Jacobs Kaltra Dhima Dario J. Englot Shawniqua Williams Roberson Sarah K. Bick Christos Constantinidis |
| author_facet | August Jurva Balbir Singh Helen Qian Zhengyang Wang Monica L. Jacobs Kaltra Dhima Dario J. Englot Shawniqua Williams Roberson Sarah K. Bick Christos Constantinidis |
| author_sort | August Jurva |
| collection | DOAJ |
| description | Executive functions, including working memory, are typically assessed clinically with neuropsychological instruments. In contrast, computerized tasks are used to test these cognitive functions in laboratory human and animal studies. Little is known of how neural activity captured by laboratory tasks relates to ability measured by clinical instruments and, by extension, clinical diagnoses of pathological conditions. We therefore sought to determine what aspects of neural activity elicited in laboratory tasks are predictive of performance in neuropsychological instruments. We recorded neural activity from intracranial electrodes implanted in human epilepsy patients as they performed laboratory working memory tasks. These patients had completed neuropsychological instruments preoperatively, including the Weschler Adult Intelligent Scale and the Wisconsin Card Sorting test. Our results revealed that increased high-gamma (70–150 Hz) power in the prefrontal and parietal cortex after presentation of visual stimuli to be remembered was indicative of lower performance in the neuropsychological tasks. On the other hand, we observed a positive correlation between high-frequency power amplitude in the delay period of the laboratory tasks and neuropsychological performance. Our results demonstrate how neural activity around task events relates to executive function and may be associated with clinical diagnosis of specific cognitive deficits. |
| format | Article |
| id | doaj-art-91f9ec0fc9914a128d65f29f0503743e |
| institution | DOAJ |
| issn | 1095-9572 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj-art-91f9ec0fc9914a128d65f29f0503743e2025-08-20T03:09:59ZengElsevierNeuroImage1095-95722025-06-0131312124010.1016/j.neuroimage.2025.121240Increased frontoparietal activity related to lower performance in neuropsychological assessment of working memoryAugust Jurva0Balbir Singh1Helen Qian2Zhengyang Wang3Monica L. Jacobs4Kaltra Dhima5Dario J. Englot6Shawniqua Williams Roberson7Sarah K. Bick8Christos Constantinidis9Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USADepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USADepartment of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN 37212, USAProgram in Neuroscience, Vanderbilt University, Nashville, TN 3723515, USADepartment of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212, USADepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN 37212, USADepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA; Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN 37212, USADepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37212, USADepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA; Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN 37212, USA; Corresponding authors.Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA; Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN 37212, USA; Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, TN 37212, USA; Corresponding authors.Executive functions, including working memory, are typically assessed clinically with neuropsychological instruments. In contrast, computerized tasks are used to test these cognitive functions in laboratory human and animal studies. Little is known of how neural activity captured by laboratory tasks relates to ability measured by clinical instruments and, by extension, clinical diagnoses of pathological conditions. We therefore sought to determine what aspects of neural activity elicited in laboratory tasks are predictive of performance in neuropsychological instruments. We recorded neural activity from intracranial electrodes implanted in human epilepsy patients as they performed laboratory working memory tasks. These patients had completed neuropsychological instruments preoperatively, including the Weschler Adult Intelligent Scale and the Wisconsin Card Sorting test. Our results revealed that increased high-gamma (70–150 Hz) power in the prefrontal and parietal cortex after presentation of visual stimuli to be remembered was indicative of lower performance in the neuropsychological tasks. On the other hand, we observed a positive correlation between high-frequency power amplitude in the delay period of the laboratory tasks and neuropsychological performance. Our results demonstrate how neural activity around task events relates to executive function and may be associated with clinical diagnosis of specific cognitive deficits.http://www.sciencedirect.com/science/article/pii/S1053811925002435Prefrontal cortexLocal field potentialStereo-EEGworking memory |
| spellingShingle | August Jurva Balbir Singh Helen Qian Zhengyang Wang Monica L. Jacobs Kaltra Dhima Dario J. Englot Shawniqua Williams Roberson Sarah K. Bick Christos Constantinidis Increased frontoparietal activity related to lower performance in neuropsychological assessment of working memory NeuroImage Prefrontal cortex Local field potential Stereo-EEG working memory |
| title | Increased frontoparietal activity related to lower performance in neuropsychological assessment of working memory |
| title_full | Increased frontoparietal activity related to lower performance in neuropsychological assessment of working memory |
| title_fullStr | Increased frontoparietal activity related to lower performance in neuropsychological assessment of working memory |
| title_full_unstemmed | Increased frontoparietal activity related to lower performance in neuropsychological assessment of working memory |
| title_short | Increased frontoparietal activity related to lower performance in neuropsychological assessment of working memory |
| title_sort | increased frontoparietal activity related to lower performance in neuropsychological assessment of working memory |
| topic | Prefrontal cortex Local field potential Stereo-EEG working memory |
| url | http://www.sciencedirect.com/science/article/pii/S1053811925002435 |
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