Inactivation of γ‐secretases leads to accumulation of substrates and non‐Alzheimer neurodegeneration

Inactivation of γ‐secretases leads to accumulation of substrates and non‐Alzheimer neurodegeneration

Abstract γ‐Secretases are a family of intramembrane cleaving aspartyl proteases and important drug targets in Alzheimer's disease. Here, we generated mice deficient for all γ‐secretases in the pyramidal neurons of the postnatal forebrain by deleting the three anterior pharynx defective 1 (Aph1)...

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Bibliographic Details
Main Authors: Hermien Acx, Lutgarde Serneels, Enrico Radaelli, Serge Muyldermans, Cécile Vincke, Elise Pepermans, Ulrike Müller, Lucía Chávez‐Gutiérrez, Bart De Strooper
Format: Article
Language:English
Published: Springer Nature 2017-06-01
Series:EMBO Molecular Medicine
Subjects:
Alzheimer's disease
Aph1 subunit
selective inhibition
side effects
γ‐Secretase
Online Access:https://doi.org/10.15252/emmm.201707561
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https://doi.org/10.15252/emmm.201707561

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