Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors.

Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors.

The intersection of genome-wide association analyses with physiological and functional data indicates that variants regulating islet gene transcription influence type 2 diabetes (T2D) predisposition and glucose homeostasis. However, the specific genes through which these regulatory variants act rema...

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Main Authors: Martijn van de Bunt, Jocelyn E Manning Fox, Xiaoqing Dai, Amy Barrett, Caleb Grey, Lei Li, Amanda J Bennett, Paul R Johnson, Raymond V Rajotte, Kyle J Gaulton, Emmanouil T Dermitzakis, Patrick E MacDonald, Mark I McCarthy, Anna L Gloyn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-12-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1005694
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