Rapid progression of carcinoma en cuirasse breast dermal metastases on 18F-fludeoxyglucose positron emission tomography–computed tomography
Cancer in the dermis of the breast has a poor prognosis. The breast dermis can become malignantly involved primarily in inflammatory breast cancer, through the direct extension of locally advanced breast cancer, or metastatically from an underlying breast mass or a distant primary malignancy (e.g.,...
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2020-01-01
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| Series: | World Journal of Nuclear Medicine |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/wjnm.WJNM_37_19 |
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| author | Colin Raymond Young Mallini Harigopal Darko Pucar |
| author_facet | Colin Raymond Young Mallini Harigopal Darko Pucar |
| author_sort | Colin Raymond Young |
| collection | DOAJ |
| description | Cancer in the dermis of the breast has a poor prognosis. The breast dermis can become malignantly involved primarily in inflammatory breast cancer, through the direct extension of locally advanced breast cancer, or metastatically from an underlying breast mass or a distant primary malignancy (e.g., gastric adenocarcinoma). Breast dermal metastases have the shortest median survival among them. Breast dermal metastases are classified into eight clinicohistopathologic groups, one of which is carcinoma en cuirasse. We present a case of a 52-year-old female with a history of invasive ductal carcinoma, Stage IIIC (pT2N3a), treated with lumpectomy, axillary node dissection, and chemoradiation therapy that recurred as carcinoma en cuirasse breast dermal metastases. Through 18F-fludeoxyglucose positron emission tomography–computed tomography (18F-FDG PET-CT) and clinical images, the case illustrates the rapid progression and devastating consequences of carcinoma en cuirasse breast dermal metastases over a 4-month period despite optimal therapy. Furthermore, the case emphasizes the sensitivity of 18F-FDG PET-CT to detect pathology in the breast dermis. Finally, the case highlights the crucial role that nuclear medicine physicians play in helping clinical colleagues differentiate between the various breast dermal malignant manifestations and benign mastitis, a common confounder in postradiation patients. |
| format | Article |
| id | doaj-art-91eef10a4a9f45a89796cec6b4e9a031 |
| institution | DOAJ |
| issn | 1450-1147 1607-3312 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | World Journal of Nuclear Medicine |
| spelling | doaj-art-91eef10a4a9f45a89796cec6b4e9a0312025-08-20T02:54:42ZengThieme Medical and Scientific Publishers Pvt. Ltd.World Journal of Nuclear Medicine1450-11471607-33122020-01-011901656810.4103/wjnm.WJNM_37_19Rapid progression of carcinoma en cuirasse breast dermal metastases on 18F-fludeoxyglucose positron emission tomography–computed tomographyColin Raymond Young0Mallini Harigopal1Darko Pucar2Department of Radiology, Yale New Haven Hospital, New Haven, CT, USADepartment of Pathology, Yale New Haven Hospital, New Haven, CT, USADepartment of Radiology, Yale New Haven Hospital, New Haven, CT, USACancer in the dermis of the breast has a poor prognosis. The breast dermis can become malignantly involved primarily in inflammatory breast cancer, through the direct extension of locally advanced breast cancer, or metastatically from an underlying breast mass or a distant primary malignancy (e.g., gastric adenocarcinoma). Breast dermal metastases have the shortest median survival among them. Breast dermal metastases are classified into eight clinicohistopathologic groups, one of which is carcinoma en cuirasse. We present a case of a 52-year-old female with a history of invasive ductal carcinoma, Stage IIIC (pT2N3a), treated with lumpectomy, axillary node dissection, and chemoradiation therapy that recurred as carcinoma en cuirasse breast dermal metastases. Through 18F-fludeoxyglucose positron emission tomography–computed tomography (18F-FDG PET-CT) and clinical images, the case illustrates the rapid progression and devastating consequences of carcinoma en cuirasse breast dermal metastases over a 4-month period despite optimal therapy. Furthermore, the case emphasizes the sensitivity of 18F-FDG PET-CT to detect pathology in the breast dermis. Finally, the case highlights the crucial role that nuclear medicine physicians play in helping clinical colleagues differentiate between the various breast dermal malignant manifestations and benign mastitis, a common confounder in postradiation patients.http://www.thieme-connect.de/DOI/DOI?10.4103/wjnm.WJNM_37_19 18f-fludeoxyglucose positron emission tomography–computed tomographybreast dermal metastasescarcinoma en cuirasseinflammatory breast cancerlocally advanced breast cancer |
| spellingShingle | Colin Raymond Young Mallini Harigopal Darko Pucar Rapid progression of carcinoma en cuirasse breast dermal metastases on 18F-fludeoxyglucose positron emission tomography–computed tomography World Journal of Nuclear Medicine 18f-fludeoxyglucose positron emission tomography–computed tomography breast dermal metastases carcinoma en cuirasse inflammatory breast cancer locally advanced breast cancer |
| title | Rapid progression of carcinoma en cuirasse breast dermal metastases on 18F-fludeoxyglucose positron emission tomography–computed tomography |
| title_full | Rapid progression of carcinoma en cuirasse breast dermal metastases on 18F-fludeoxyglucose positron emission tomography–computed tomography |
| title_fullStr | Rapid progression of carcinoma en cuirasse breast dermal metastases on 18F-fludeoxyglucose positron emission tomography–computed tomography |
| title_full_unstemmed | Rapid progression of carcinoma en cuirasse breast dermal metastases on 18F-fludeoxyglucose positron emission tomography–computed tomography |
| title_short | Rapid progression of carcinoma en cuirasse breast dermal metastases on 18F-fludeoxyglucose positron emission tomography–computed tomography |
| title_sort | rapid progression of carcinoma en cuirasse breast dermal metastases on 18f fludeoxyglucose positron emission tomography computed tomography |
| topic | 18f-fludeoxyglucose positron emission tomography–computed tomography breast dermal metastases carcinoma en cuirasse inflammatory breast cancer locally advanced breast cancer |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/wjnm.WJNM_37_19 |
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