The Impact of Diet on Lipoprotein(a) Levels
Background: Lipoprotein(a) [Lp(a)] is recognized as an independent risk factor for cardiovascular diseases; however, the impact of fat-based diets on its levels remains unclear. Objective: This study aims to assess and analyze current evidence on the impact of various types of fat-based diets on Lp(...
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2024-10-01
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| author | Michał Stojko Aleksandra Spychał Kamil Nikel Rafał Kołodziej Jolanta Zalejska-Fiolka |
| author_facet | Michał Stojko Aleksandra Spychał Kamil Nikel Rafał Kołodziej Jolanta Zalejska-Fiolka |
| author_sort | Michał Stojko |
| collection | DOAJ |
| description | Background: Lipoprotein(a) [Lp(a)] is recognized as an independent risk factor for cardiovascular diseases; however, the impact of fat-based diets on its levels remains unclear. Objective: This study aims to assess and analyze current evidence on the impact of various types of fat-based diets on Lp(a) levels. Material and Methods: A comprehensive search of the PubMed database was conducted on 9 July 2024, focusing on clinical and randomized trials published since 2000. Out of 697 identified studies, 33 met the inclusion criteria and were selected for analysis. Results: The findings suggest that modifications in fat-based diets, particularly concerning the type and amount of consumed fats and fatty acids, can significantly influence plasma Lp(a) levels. Diets rich in unsaturated fats, including polyunsaturated and monounsaturated fatty acids, were associated with more favorable effects in lowering Lp(a) levels. In contrast, diets high in saturated fats were linked to elevated Lp(a) levels. However, these conclusions were not consistent across all studies considered. Conclusions: This work highlights the importance of a personalized dietary approach, considering both genetic predispositions and dietary habits. While diet alone may not drastically alter Lp(a) levels due to their strong genetic determination, a comprehensive strategy involving a healthy diet rich in unsaturated fats, regular physical activity, and effective weight management is recommended to reduce the risk of cardiovascular diseases. Further research is needed to clarify the mechanisms through which different fats affect Lp(a) and to develop targeted dietary recommendations. |
| format | Article |
| id | doaj-art-91eee43f86e940b99119a44a3b7f81b2 |
| institution | OA Journals |
| issn | 2075-1729 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
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| series | Life |
| spelling | doaj-art-91eee43f86e940b99119a44a3b7f81b22025-08-20T01:54:07ZengMDPI AGLife2075-17292024-10-011411140310.3390/life14111403The Impact of Diet on Lipoprotein(a) LevelsMichał Stojko0Aleksandra Spychał1Kamil Nikel2Rafał Kołodziej3Jolanta Zalejska-Fiolka4Scientific Society of the Department and Chair of Biochemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 40-055 Katowice, PolandScientific Society of the Department and Chair of Biochemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 40-055 Katowice, PolandScientific Society of the Department and Chair of Biochemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 40-055 Katowice, PolandStudents Scientific Association, Department of Immunology, Faculty of Medical Science, University of Rzeszów, 35001 Rzeszów, PolandDepartment and Chair of Biochemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 40-055 Katowice, PolandBackground: Lipoprotein(a) [Lp(a)] is recognized as an independent risk factor for cardiovascular diseases; however, the impact of fat-based diets on its levels remains unclear. Objective: This study aims to assess and analyze current evidence on the impact of various types of fat-based diets on Lp(a) levels. Material and Methods: A comprehensive search of the PubMed database was conducted on 9 July 2024, focusing on clinical and randomized trials published since 2000. Out of 697 identified studies, 33 met the inclusion criteria and were selected for analysis. Results: The findings suggest that modifications in fat-based diets, particularly concerning the type and amount of consumed fats and fatty acids, can significantly influence plasma Lp(a) levels. Diets rich in unsaturated fats, including polyunsaturated and monounsaturated fatty acids, were associated with more favorable effects in lowering Lp(a) levels. In contrast, diets high in saturated fats were linked to elevated Lp(a) levels. However, these conclusions were not consistent across all studies considered. Conclusions: This work highlights the importance of a personalized dietary approach, considering both genetic predispositions and dietary habits. While diet alone may not drastically alter Lp(a) levels due to their strong genetic determination, a comprehensive strategy involving a healthy diet rich in unsaturated fats, regular physical activity, and effective weight management is recommended to reduce the risk of cardiovascular diseases. Further research is needed to clarify the mechanisms through which different fats affect Lp(a) and to develop targeted dietary recommendations.https://www.mdpi.com/2075-1729/14/11/1403lipoprotein(a)dietfatslipids |
| spellingShingle | Michał Stojko Aleksandra Spychał Kamil Nikel Rafał Kołodziej Jolanta Zalejska-Fiolka The Impact of Diet on Lipoprotein(a) Levels Life lipoprotein(a) diet fats lipids |
| title | The Impact of Diet on Lipoprotein(a) Levels |
| title_full | The Impact of Diet on Lipoprotein(a) Levels |
| title_fullStr | The Impact of Diet on Lipoprotein(a) Levels |
| title_full_unstemmed | The Impact of Diet on Lipoprotein(a) Levels |
| title_short | The Impact of Diet on Lipoprotein(a) Levels |
| title_sort | impact of diet on lipoprotein a levels |
| topic | lipoprotein(a) diet fats lipids |
| url | https://www.mdpi.com/2075-1729/14/11/1403 |
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