The Plasma Membrane Potential and the Organization of the Actin Cytoskeleton of Epithelial Cells
The establishment and maintenance of the polarized epithelial phenotype require a characteristic organization of the cytoskeletal components. There are many cellular effectors involved in the regulation of the cytoskeleton of epithelial cells. Recently, modifications in the plasma membrane potential...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2012/121424 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849403984230481920 |
|---|---|
| author | Silvia Chifflet Julio A. Hernández |
| author_facet | Silvia Chifflet Julio A. Hernández |
| author_sort | Silvia Chifflet |
| collection | DOAJ |
| description | The establishment and maintenance of the polarized epithelial phenotype require a characteristic organization of the cytoskeletal components. There are many cellular effectors involved in the regulation of the cytoskeleton of epithelial cells. Recently, modifications in the plasma membrane potential (PMP) have been suggested to participate in the modulation of the cytoskeletal organization of epithelia. Here, we review evidence showing that changes in the PMP of diverse epithelial cells promote characteristic modifications in the cytoskeletal organization, with a focus on the actin cytoskeleton. The molecular paths mediating these effects may include voltage-sensitive integral membrane proteins and/or peripheral proteins sensitive to surface potentials. The voltage dependence of the cytoskeletal organization seems to have implications in several physiological processes, including epithelial wound healing and apoptosis. |
| format | Article |
| id | doaj-art-91ede8fad4194e098aacf12690978be7 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-91ede8fad4194e098aacf12690978be72025-08-20T03:37:07ZengWileyInternational Journal of Cell Biology1687-88761687-88842012-01-01201210.1155/2012/121424121424The Plasma Membrane Potential and the Organization of the Actin Cytoskeleton of Epithelial CellsSilvia Chifflet0Julio A. Hernández1Departamento de Bioquímica, Facultad de Medicina, Universidad de la República, Gral. Flores 2125, 11800 Montevideo, UruguaySección Biofísica, Facultad de Ciencias, Universidad de la República, Iguá 4225 esq. Mataojo, 11400 Montevideo, UruguayThe establishment and maintenance of the polarized epithelial phenotype require a characteristic organization of the cytoskeletal components. There are many cellular effectors involved in the regulation of the cytoskeleton of epithelial cells. Recently, modifications in the plasma membrane potential (PMP) have been suggested to participate in the modulation of the cytoskeletal organization of epithelia. Here, we review evidence showing that changes in the PMP of diverse epithelial cells promote characteristic modifications in the cytoskeletal organization, with a focus on the actin cytoskeleton. The molecular paths mediating these effects may include voltage-sensitive integral membrane proteins and/or peripheral proteins sensitive to surface potentials. The voltage dependence of the cytoskeletal organization seems to have implications in several physiological processes, including epithelial wound healing and apoptosis.http://dx.doi.org/10.1155/2012/121424 |
| spellingShingle | Silvia Chifflet Julio A. Hernández The Plasma Membrane Potential and the Organization of the Actin Cytoskeleton of Epithelial Cells International Journal of Cell Biology |
| title | The Plasma Membrane Potential and the Organization of the Actin Cytoskeleton of Epithelial Cells |
| title_full | The Plasma Membrane Potential and the Organization of the Actin Cytoskeleton of Epithelial Cells |
| title_fullStr | The Plasma Membrane Potential and the Organization of the Actin Cytoskeleton of Epithelial Cells |
| title_full_unstemmed | The Plasma Membrane Potential and the Organization of the Actin Cytoskeleton of Epithelial Cells |
| title_short | The Plasma Membrane Potential and the Organization of the Actin Cytoskeleton of Epithelial Cells |
| title_sort | plasma membrane potential and the organization of the actin cytoskeleton of epithelial cells |
| url | http://dx.doi.org/10.1155/2012/121424 |
| work_keys_str_mv | AT silviachifflet theplasmamembranepotentialandtheorganizationoftheactincytoskeletonofepithelialcells AT julioahernandez theplasmamembranepotentialandtheorganizationoftheactincytoskeletonofepithelialcells AT silviachifflet plasmamembranepotentialandtheorganizationoftheactincytoskeletonofepithelialcells AT julioahernandez plasmamembranepotentialandtheorganizationoftheactincytoskeletonofepithelialcells |