Advances on relationship between phthalate exposure and perinatal depression
Perinatal depression is a psychological disorder that occurs during pregnancy and within one year of delivery, which can seriously affect the physical and mental health of pregnant and postpartum women, as well as the cognitive and behavioral abilities of offspring, with potential multigenerational...
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| Format: | Article |
| Language: | English |
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Editorial Committee of Journal of Environmental and Occupational Medicine
2024-12-01
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| Series: | 环境与职业医学 |
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| Online Access: | http://www.jeom.org/article/cn/10.11836/JEOM24197 |
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| author | Yueming XU Mei ZHAO Yichao HUANG Lingling YU Lan GENG Lei CHEN |
| author_facet | Yueming XU Mei ZHAO Yichao HUANG Lingling YU Lan GENG Lei CHEN |
| author_sort | Yueming XU |
| collection | DOAJ |
| description | Perinatal depression is a psychological disorder that occurs during pregnancy and within one year of delivery, which can seriously affect the physical and mental health of pregnant and postpartum women, as well as the cognitive and behavioral abilities of offspring, with potential multigenerational effects. Therefore, it is important to identify its potential modifiable risk factors. Phthalic acid esters (PAEs), as common environmental endocrine disruptors, can affect maternal estrogen through multiple mechanisms and are important potential modifiable risk factors for developing maternal perinatal depression. At present, studies on the correlation between PAEs and perinatal depression are still very limited, and the mechanisms by which PAEs affect perinatal depression have not been clarified. Based on existing epidemiological and toxicological studies at home and abroad, the article briefly introduced the characteristics of multiple pathways, high doses, and long-term exposure to maternal PAEs, focused on reviewing the current status of epidemiological studies, pointed out the possible associations between some specific PAEs exposure and elevated risk of perinatal depression. It also summarized the potential roles of hormone-neurotransmitter pathway, inflammation mediation, gene regulation, and other possible mechanisms in the association between exposure to PAEs and perinatal depression. The article concluded with a look at how future research on the association between exposure to PAEs and perinatal depression can be scientifically validated, with a view to providing more high-quality evidence for the scientific prevention of the onset and progression of maternal depressive symptoms. |
| format | Article |
| id | doaj-art-91e3c8e1aece44c6a49cf271744f7431 |
| institution | Kabale University |
| issn | 2095-9982 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Editorial Committee of Journal of Environmental and Occupational Medicine |
| record_format | Article |
| series | 环境与职业医学 |
| spelling | doaj-art-91e3c8e1aece44c6a49cf271744f74312025-01-09T05:41:13ZengEditorial Committee of Journal of Environmental and Occupational Medicine环境与职业医学2095-99822024-12-0141121446145110.11836/JEOM2419724197Advances on relationship between phthalate exposure and perinatal depressionYueming XU0Mei ZHAO1Yichao HUANG2Lingling YU3Lan GENG4Lei CHEN5Anhui Medical University School of NursingAnhui Medical University School of NursingAnhui Medical University School of Public Health, Anhui Medical University, Hefei, Anhui 230032, ChinaAnhui Medical University School of NursingAnhui Medical University School of NursingAnhui Medical University School of NursingPerinatal depression is a psychological disorder that occurs during pregnancy and within one year of delivery, which can seriously affect the physical and mental health of pregnant and postpartum women, as well as the cognitive and behavioral abilities of offspring, with potential multigenerational effects. Therefore, it is important to identify its potential modifiable risk factors. Phthalic acid esters (PAEs), as common environmental endocrine disruptors, can affect maternal estrogen through multiple mechanisms and are important potential modifiable risk factors for developing maternal perinatal depression. At present, studies on the correlation between PAEs and perinatal depression are still very limited, and the mechanisms by which PAEs affect perinatal depression have not been clarified. Based on existing epidemiological and toxicological studies at home and abroad, the article briefly introduced the characteristics of multiple pathways, high doses, and long-term exposure to maternal PAEs, focused on reviewing the current status of epidemiological studies, pointed out the possible associations between some specific PAEs exposure and elevated risk of perinatal depression. It also summarized the potential roles of hormone-neurotransmitter pathway, inflammation mediation, gene regulation, and other possible mechanisms in the association between exposure to PAEs and perinatal depression. The article concluded with a look at how future research on the association between exposure to PAEs and perinatal depression can be scientifically validated, with a view to providing more high-quality evidence for the scientific prevention of the onset and progression of maternal depressive symptoms.http://www.jeom.org/article/cn/10.11836/JEOM24197phthalic acid estersmaternalperinatal depressionexposurebiological mechanism |
| spellingShingle | Yueming XU Mei ZHAO Yichao HUANG Lingling YU Lan GENG Lei CHEN Advances on relationship between phthalate exposure and perinatal depression 环境与职业医学 phthalic acid esters maternal perinatal depression exposure biological mechanism |
| title | Advances on relationship between phthalate exposure and perinatal depression |
| title_full | Advances on relationship between phthalate exposure and perinatal depression |
| title_fullStr | Advances on relationship between phthalate exposure and perinatal depression |
| title_full_unstemmed | Advances on relationship between phthalate exposure and perinatal depression |
| title_short | Advances on relationship between phthalate exposure and perinatal depression |
| title_sort | advances on relationship between phthalate exposure and perinatal depression |
| topic | phthalic acid esters maternal perinatal depression exposure biological mechanism |
| url | http://www.jeom.org/article/cn/10.11836/JEOM24197 |
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