Case Report: Azathioprine-induced Sweet’s syndrome with associated myocardial infarction
Sweet’s syndrome (SS) is an acute febrile neutrophilic dermatosis characterized by a rash with tender erythematous plaques or nodules, fevers and leukocytosis. Drug-induced SS is a subtype of SS which is associated with a growing number of medications including azathioprine (AZA). Cardiovascular com...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1548941/full |
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| author | Natalie Commins Deloshaan Subhaharan Deloshaan Subhaharan Lauren White |
| author_facet | Natalie Commins Deloshaan Subhaharan Deloshaan Subhaharan Lauren White |
| author_sort | Natalie Commins |
| collection | DOAJ |
| description | Sweet’s syndrome (SS) is an acute febrile neutrophilic dermatosis characterized by a rash with tender erythematous plaques or nodules, fevers and leukocytosis. Drug-induced SS is a subtype of SS which is associated with a growing number of medications including azathioprine (AZA). Cardiovascular complications secondary to SS are rare but have been described in case reports and include myocardial infarction and myopericarditis. We report a man in his 60’s with left-sided colonic inflammatory bowel disease (IBD) and perianal disease who developed SS 3 weeks post commencement of AZA. His admission was complicated by an inferolateral ST elevation myocardial infarction occurring concurrently with SS. Clinical improvement occurred with AZA cessation and introduction of intravenous steroids. |
| format | Article |
| id | doaj-art-91e1204f1b6047d1b671086d7bd933cd |
| institution | OA Journals |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-91e1204f1b6047d1b671086d7bd933cd2025-08-20T01:57:11ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-05-011210.3389/fmed.2025.15489411548941Case Report: Azathioprine-induced Sweet’s syndrome with associated myocardial infarctionNatalie Commins0Deloshaan Subhaharan1Deloshaan Subhaharan2Lauren White3Department of Gastroenterology, Sunshine Coast University Hospital, Birtinya, QLD, AustraliaDepartment of Gastroenterology, Sunshine Coast University Hospital, Birtinya, QLD, AustraliaDepartment of Gastroenterology, Gold Coast University Hospital, Southport, QLD, AustraliaDepartment of Gastroenterology, Sunshine Coast University Hospital, Birtinya, QLD, AustraliaSweet’s syndrome (SS) is an acute febrile neutrophilic dermatosis characterized by a rash with tender erythematous plaques or nodules, fevers and leukocytosis. Drug-induced SS is a subtype of SS which is associated with a growing number of medications including azathioprine (AZA). Cardiovascular complications secondary to SS are rare but have been described in case reports and include myocardial infarction and myopericarditis. We report a man in his 60’s with left-sided colonic inflammatory bowel disease (IBD) and perianal disease who developed SS 3 weeks post commencement of AZA. His admission was complicated by an inferolateral ST elevation myocardial infarction occurring concurrently with SS. Clinical improvement occurred with AZA cessation and introduction of intravenous steroids.https://www.frontiersin.org/articles/10.3389/fmed.2025.1548941/fullSweet’s syndromeinflammatory bowel diseaseazathioprinemyocardial infarctiondrug reaction |
| spellingShingle | Natalie Commins Deloshaan Subhaharan Deloshaan Subhaharan Lauren White Case Report: Azathioprine-induced Sweet’s syndrome with associated myocardial infarction Frontiers in Medicine Sweet’s syndrome inflammatory bowel disease azathioprine myocardial infarction drug reaction |
| title | Case Report: Azathioprine-induced Sweet’s syndrome with associated myocardial infarction |
| title_full | Case Report: Azathioprine-induced Sweet’s syndrome with associated myocardial infarction |
| title_fullStr | Case Report: Azathioprine-induced Sweet’s syndrome with associated myocardial infarction |
| title_full_unstemmed | Case Report: Azathioprine-induced Sweet’s syndrome with associated myocardial infarction |
| title_short | Case Report: Azathioprine-induced Sweet’s syndrome with associated myocardial infarction |
| title_sort | case report azathioprine induced sweet s syndrome with associated myocardial infarction |
| topic | Sweet’s syndrome inflammatory bowel disease azathioprine myocardial infarction drug reaction |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1548941/full |
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