Curcumin enhances bedaquiline’s efficacy against Mycobacterium abscessus: in vitro and in vivo evidence

Curcumin enhances bedaquiline’s efficacy against Mycobacterium abscessus: in vitro and in vivo evidence

ABSTRACT In this study, we describe the combined effects of bedaquiline (BDQ) and the natural product curcumin (CUR) on Mycobacterium abscessus. In both in vitro and in vivo experiments, CUR enhanced BDQ’s inhibitory effect. This combination reduced M. abscessus survival under nutrient-deprived, hyp...

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Bibliographic Details
Main Authors: Dan Luo, Weile Xie, Zhe Wang
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:Microbiology Spectrum
Subjects:
Mycobacterium abscessus
bedaquiline
curcumin
synergy
combination
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02295-24
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