Antimicrobial susceptibility of Salmonella Typhi in India
Background: Typhoid fever continues to remain a major public health problem, especially in regions such as Gulbarga, due to poor sanitation and personal hygiene. Gulbarga region is often prone to enteric fever outbreaks and is an endemic region of typhoid fever. Enteric fever caused by Salmonella T...
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The Journal of Infection in Developing Countries
2009-12-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/109 |
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| author | Kavita Nagshetty Shivannavar T. Channappa Subhashchandra M. Gaddad |
| author_facet | Kavita Nagshetty Shivannavar T. Channappa Subhashchandra M. Gaddad |
| author_sort | Kavita Nagshetty |
| collection | DOAJ |
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Background: Typhoid fever continues to remain a major public health problem, especially in regions such as Gulbarga, due to poor sanitation and personal hygiene. Gulbarga region is often prone to enteric fever outbreaks and is an endemic region of typhoid fever. Enteric fever caused by Salmonella Typhi has not been adequately explored in this region.
Methodology: A total of 95 isolates of S. Typhi collected from different clinical and environmental sources were tested for antimicrobial susceptibility according to the CLSI guidelines. MIC of resistant isolates to various antibiotics was performed by agar dilution method.
Results: Of the total isolates studied, 10% were found to be multidrug resistant (MDR) (defined as resistance to ampicillin, chloramphenicol and co-trimoxazole). There was a decrease in the susceptibility to ciprofloxacin of S. Typhi with MIC showing an upward trend (0.125-4µg/mL). Concurrently, there has been an increase in the number of isolates sensitive to all antibiotics except nalidixic acid.
Conclusion: MDR S. Typhi continues to be an important public health issue in Gulbarga. Presence of quinolone resistance and associated low-level ciprofloxacin resistance is a concern and requires further study.
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| format | Article |
| id | doaj-art-91d6765d0e95407d94bd692b64dc6ee1 |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2009-12-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-91d6765d0e95407d94bd692b64dc6ee12025-08-20T02:16:15ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802009-12-0140210.3855/jidc.109Antimicrobial susceptibility of Salmonella Typhi in IndiaKavita Nagshetty0Shivannavar T. Channappa1Subhashchandra M. Gaddad2Gulbarga University Gulbarga, KarnatakaGulbarga University Gulbarga, KarnatakaGulbarga University Gulbarga, Karnataka Background: Typhoid fever continues to remain a major public health problem, especially in regions such as Gulbarga, due to poor sanitation and personal hygiene. Gulbarga region is often prone to enteric fever outbreaks and is an endemic region of typhoid fever. Enteric fever caused by Salmonella Typhi has not been adequately explored in this region. Methodology: A total of 95 isolates of S. Typhi collected from different clinical and environmental sources were tested for antimicrobial susceptibility according to the CLSI guidelines. MIC of resistant isolates to various antibiotics was performed by agar dilution method. Results: Of the total isolates studied, 10% were found to be multidrug resistant (MDR) (defined as resistance to ampicillin, chloramphenicol and co-trimoxazole). There was a decrease in the susceptibility to ciprofloxacin of S. Typhi with MIC showing an upward trend (0.125-4µg/mL). Concurrently, there has been an increase in the number of isolates sensitive to all antibiotics except nalidixic acid. Conclusion: MDR S. Typhi continues to be an important public health issue in Gulbarga. Presence of quinolone resistance and associated low-level ciprofloxacin resistance is a concern and requires further study. https://jidc.org/index.php/journal/article/view/109typhoidmultidrug resistanceSalmonella Typhi |
| spellingShingle | Kavita Nagshetty Shivannavar T. Channappa Subhashchandra M. Gaddad Antimicrobial susceptibility of Salmonella Typhi in India Journal of Infection in Developing Countries typhoid multidrug resistance Salmonella Typhi |
| title | Antimicrobial susceptibility of Salmonella Typhi in India |
| title_full | Antimicrobial susceptibility of Salmonella Typhi in India |
| title_fullStr | Antimicrobial susceptibility of Salmonella Typhi in India |
| title_full_unstemmed | Antimicrobial susceptibility of Salmonella Typhi in India |
| title_short | Antimicrobial susceptibility of Salmonella Typhi in India |
| title_sort | antimicrobial susceptibility of salmonella typhi in india |
| topic | typhoid multidrug resistance Salmonella Typhi |
| url | https://jidc.org/index.php/journal/article/view/109 |
| work_keys_str_mv | AT kavitanagshetty antimicrobialsusceptibilityofsalmonellatyphiinindia AT shivannavartchannappa antimicrobialsusceptibilityofsalmonellatyphiinindia AT subhashchandramgaddad antimicrobialsusceptibilityofsalmonellatyphiinindia |