Lipid Dysmetabolism in Canine Chronic Liver Disease: Relationship Between Clinical, Histological and Immunohistochemical Features
Chronic liver diseases (CLDs) in dogs are progressive conditions that often lead to liver failure. Metabolic dysfunctions such as cholestasis, obesity, hyperlipidemia, and endocrine disorders play a key role in human liver diseases like MASLD (Metabolic Dysfunction Associated Steatotic Liver Disease...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-03-01
|
| Series: | Veterinary Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2306-7381/12/3/220 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849339939494297600 |
|---|---|
| author | Verena Habermaass Yuki Takami Takeshi Izawa Francesca Abramo Corrado Biolatti Veronica Marchetti |
| author_facet | Verena Habermaass Yuki Takami Takeshi Izawa Francesca Abramo Corrado Biolatti Veronica Marchetti |
| author_sort | Verena Habermaass |
| collection | DOAJ |
| description | Chronic liver diseases (CLDs) in dogs are progressive conditions that often lead to liver failure. Metabolic dysfunctions such as cholestasis, obesity, hyperlipidemia, and endocrine disorders play a key role in human liver diseases like MASLD (Metabolic Dysfunction Associated Steatotic Liver Disease) and MASH (Metabolic Dysfunction Associated Steatohepatitis), but their significance in canine CLDs is poorly understood. This study aims to evaluate the association between hepatic lipid accumulation and inflammation or fibrosis in canine CLDs and its potential association with metabolic dysfunctions. Sixteen client-owned dogs with CLDs were assessed for clinical data, histological features, and liver immunohistochemistry (IHC). Histological and IHC markers of inflammation (Iba-1, iNOS, NF-κB), fibrosis (CD206, α-SMA, Sirius Red), and lipid accumulation (adipophilin) were assessed to identify correlations with clinical conditions. The applied markers showed effectiveness in their use on canine liver tissue. Adipophilin-marked lipid accumulation correlated positively with inflammatory markers, indicating a link between steatosis and inflammation. Metabolic dysfunctions were linked to hepatic lipid accumulation and inflammation. These findings show a potential alignment of canine CLDs with human MASLD/MASH, where lipid-induced inflammation drives disease progression. IHC markers could effectively assess these processes, suggesting potential for guiding diagnostics and therapies, though further research is needed to clarify clinical associations. |
| format | Article |
| id | doaj-art-91d26264da7e44c3946fba8a7b9d9a36 |
| institution | Kabale University |
| issn | 2306-7381 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj-art-91d26264da7e44c3946fba8a7b9d9a362025-08-20T03:44:01ZengMDPI AGVeterinary Sciences2306-73812025-03-0112322010.3390/vetsci12030220Lipid Dysmetabolism in Canine Chronic Liver Disease: Relationship Between Clinical, Histological and Immunohistochemical FeaturesVerena Habermaass0Yuki Takami1Takeshi Izawa2Francesca Abramo3Corrado Biolatti4Veronica Marchetti5Department of Veterinary Sciences, University of Pisa, Via Livornese Lato Monte, 56122 Pisa, ItalyLaboratory of Veterinary Pathology, Osaka Metropolitan University, 1-58 Rinku-Ourai-Kita, Izumisano-shi, Osaka 598-8531, JapanLaboratory of Veterinary Pathology, Osaka Metropolitan University, 1-58 Rinku-Ourai-Kita, Izumisano-shi, Osaka 598-8531, JapanDepartment of Veterinary Sciences, University of Pisa, Via Livornese Lato Monte, 56122 Pisa, ItalyIndependent Researcher, 6340 Baar, SwitzerlandDepartment of Veterinary Sciences, University of Pisa, Via Livornese Lato Monte, 56122 Pisa, ItalyChronic liver diseases (CLDs) in dogs are progressive conditions that often lead to liver failure. Metabolic dysfunctions such as cholestasis, obesity, hyperlipidemia, and endocrine disorders play a key role in human liver diseases like MASLD (Metabolic Dysfunction Associated Steatotic Liver Disease) and MASH (Metabolic Dysfunction Associated Steatohepatitis), but their significance in canine CLDs is poorly understood. This study aims to evaluate the association between hepatic lipid accumulation and inflammation or fibrosis in canine CLDs and its potential association with metabolic dysfunctions. Sixteen client-owned dogs with CLDs were assessed for clinical data, histological features, and liver immunohistochemistry (IHC). Histological and IHC markers of inflammation (Iba-1, iNOS, NF-κB), fibrosis (CD206, α-SMA, Sirius Red), and lipid accumulation (adipophilin) were assessed to identify correlations with clinical conditions. The applied markers showed effectiveness in their use on canine liver tissue. Adipophilin-marked lipid accumulation correlated positively with inflammatory markers, indicating a link between steatosis and inflammation. Metabolic dysfunctions were linked to hepatic lipid accumulation and inflammation. These findings show a potential alignment of canine CLDs with human MASLD/MASH, where lipid-induced inflammation drives disease progression. IHC markers could effectively assess these processes, suggesting potential for guiding diagnostics and therapies, though further research is needed to clarify clinical associations.https://www.mdpi.com/2306-7381/12/3/220lipidlivercholestasisobesitycanineimmunohistochemistry |
| spellingShingle | Verena Habermaass Yuki Takami Takeshi Izawa Francesca Abramo Corrado Biolatti Veronica Marchetti Lipid Dysmetabolism in Canine Chronic Liver Disease: Relationship Between Clinical, Histological and Immunohistochemical Features Veterinary Sciences lipid liver cholestasis obesity canine immunohistochemistry |
| title | Lipid Dysmetabolism in Canine Chronic Liver Disease: Relationship Between Clinical, Histological and Immunohistochemical Features |
| title_full | Lipid Dysmetabolism in Canine Chronic Liver Disease: Relationship Between Clinical, Histological and Immunohistochemical Features |
| title_fullStr | Lipid Dysmetabolism in Canine Chronic Liver Disease: Relationship Between Clinical, Histological and Immunohistochemical Features |
| title_full_unstemmed | Lipid Dysmetabolism in Canine Chronic Liver Disease: Relationship Between Clinical, Histological and Immunohistochemical Features |
| title_short | Lipid Dysmetabolism in Canine Chronic Liver Disease: Relationship Between Clinical, Histological and Immunohistochemical Features |
| title_sort | lipid dysmetabolism in canine chronic liver disease relationship between clinical histological and immunohistochemical features |
| topic | lipid liver cholestasis obesity canine immunohistochemistry |
| url | https://www.mdpi.com/2306-7381/12/3/220 |
| work_keys_str_mv | AT verenahabermaass lipiddysmetabolismincaninechronicliverdiseaserelationshipbetweenclinicalhistologicalandimmunohistochemicalfeatures AT yukitakami lipiddysmetabolismincaninechronicliverdiseaserelationshipbetweenclinicalhistologicalandimmunohistochemicalfeatures AT takeshiizawa lipiddysmetabolismincaninechronicliverdiseaserelationshipbetweenclinicalhistologicalandimmunohistochemicalfeatures AT francescaabramo lipiddysmetabolismincaninechronicliverdiseaserelationshipbetweenclinicalhistologicalandimmunohistochemicalfeatures AT corradobiolatti lipiddysmetabolismincaninechronicliverdiseaserelationshipbetweenclinicalhistologicalandimmunohistochemicalfeatures AT veronicamarchetti lipiddysmetabolismincaninechronicliverdiseaserelationshipbetweenclinicalhistologicalandimmunohistochemicalfeatures |