METTL3-mediated methylation of RAC2 contributes to cell motility, oxidative stress and inflammation in TNF‐α-stimulated rheumatoid arthritis fibroblast-like synovial cells

METTL3-mediated methylation of RAC2 contributes to cell motility, oxidative stress and inflammation in TNF‐α-stimulated rheumatoid arthritis fibroblast-like synovial cells

Abstract Background Rheumatoid arthritis (RA) is a widely prevalent rheumatic condition causing joint inflammation and damage. RNA methylation plays an important role in RA. Herein, we intended to investigate the function of methyltransferase-like 3 (METTL3) and its N6-methyladenosine (m6A) methylat...

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Bibliographic Details
Main Authors: Hua Ren, Guohua Wei, Ziwei Kong, Mengyang Zhang, Yuejin Li, Sanjiao Liu, Yifan Guo
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
METTL3
RAC2
Rheumatoid arthritis
M6A methylation modification
Online Access:https://doi.org/10.1186/s13018-025-05526-4
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