Clinical significance of androgen receptor in unilateral invasive breast cancer in women
Abstract Objective To assess the prognostic relevance of androgen receptor (AR) expression in patients following modified radical surgery for invasive breast cancer. Methods A cohort of 515 patients who underwent modified radical mastectomy for breast cancer from July 2016 to November 2017 was analy...
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| Format: | Article |
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BMC
2025-08-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-025-03072-7 |
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| author | Menghan Cao Di Pan Yuqi Li Zicheng Pei Runbang Wang Bo Zhang Chaorong Bian Qinghao Gu Pengfei Qu Chenchen Yu Haonan Liu Zhengxiang Han |
| author_facet | Menghan Cao Di Pan Yuqi Li Zicheng Pei Runbang Wang Bo Zhang Chaorong Bian Qinghao Gu Pengfei Qu Chenchen Yu Haonan Liu Zhengxiang Han |
| author_sort | Menghan Cao |
| collection | DOAJ |
| description | Abstract Objective To assess the prognostic relevance of androgen receptor (AR) expression in patients following modified radical surgery for invasive breast cancer. Methods A cohort of 515 patients who underwent modified radical mastectomy for breast cancer from July 2016 to November 2017 was analyzed. Immunohistochemistry was employed to determine the expression levels of AR, estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (HER-2), cell proliferation nuclear antigen (Ki-67), oncogene (P-53), cytokeratin 5/6 (CK5/6), topoisomerase-2 (TOPO-2), and epidermal growth factor receptor (EGFR). The correlation between AR expression and clinicopathological features as well as prognosis was examined. Multifactorial analysis using Cox proportional risk regression identified independent prognostic factors for disease-free survival (DFS), and a nomogram model was developed based on these factors. Results Patients in the AR-positive group demonstrated a significantly higher frequency of low histologic grade (grade 1–2), ER positive, PR positive, TOPO-2-negative, CK5/6-negative, and EGFR-negative as compared to the AR-negative group (P < 0.05). Among ER( +)/HER-2(−) and ER( +)/HER-2( +) patients with breast cancer, AR-positive individuals exhibited prolonged DFS (P < 0.05). Conversely, in ER(−)/HER-2( +) and ER(−)/HER-2(−) patients with breast cancer, AR expression did not significantly influence disease-free survival (P > 0.05). Multifactorial regression analysis identified AR/ER ratio, histological classification, and lymph node metastasis as independent prognostic factors for DFS (all P < 0.05). The developed nomogram model underscored the significance of histological classification as the primary predictive factor for patient outcomes, followed by AR/ER ratio and lymph node metastasis Conclusion AR expression holds varying prognostic implications across different breast cancer subtypes, with AR positivity indicating a favorable prognosis, particularly in ER-positive tumors. |
| format | Article |
| id | doaj-art-91cff875fadb48778673f2622889f6c2 |
| institution | Kabale University |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-91cff875fadb48778673f2622889f6c22025-08-24T11:15:09ZengBMCEuropean Journal of Medical Research2047-783X2025-08-0130111910.1186/s40001-025-03072-7Clinical significance of androgen receptor in unilateral invasive breast cancer in womenMenghan Cao0Di Pan1Yuqi Li2Zicheng Pei3Runbang Wang4Bo Zhang5Chaorong Bian6Qinghao Gu7Pengfei Qu8Chenchen Yu9Haonan Liu10Zhengxiang Han11Department of Oncology, The Affiliated Hospital of Xuzhou Medical UniversityDepartment of Oncology, Nanjing Medical UniversitySchool of Laboratory Medicine, Bengbu Medical UniversityDepartment of Oncology, The Affiliated Hospital of Xuzhou Medical UniversityThe First College of Clinical Medicine, Xuzhou Medical UniversityDepartment of Radiation Therapy, Xuzhou Xinjiankang HospitalThe First College of Clinical Medicine, Xuzhou Medical UniversityThe First College of Clinical Medicine, Xuzhou Medical UniversityDepartment of Gastroenterology, The Second Affiliated Hospital of Xuzhou Medical UniversityThe First College of Clinical Medicine, Xuzhou Medical UniversityDepartment of Oncology, The Affiliated Hospital of Xuzhou Medical UniversityDepartment of Oncology, The Affiliated Hospital of Xuzhou Medical UniversityAbstract Objective To assess the prognostic relevance of androgen receptor (AR) expression in patients following modified radical surgery for invasive breast cancer. Methods A cohort of 515 patients who underwent modified radical mastectomy for breast cancer from July 2016 to November 2017 was analyzed. Immunohistochemistry was employed to determine the expression levels of AR, estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (HER-2), cell proliferation nuclear antigen (Ki-67), oncogene (P-53), cytokeratin 5/6 (CK5/6), topoisomerase-2 (TOPO-2), and epidermal growth factor receptor (EGFR). The correlation between AR expression and clinicopathological features as well as prognosis was examined. Multifactorial analysis using Cox proportional risk regression identified independent prognostic factors for disease-free survival (DFS), and a nomogram model was developed based on these factors. Results Patients in the AR-positive group demonstrated a significantly higher frequency of low histologic grade (grade 1–2), ER positive, PR positive, TOPO-2-negative, CK5/6-negative, and EGFR-negative as compared to the AR-negative group (P < 0.05). Among ER( +)/HER-2(−) and ER( +)/HER-2( +) patients with breast cancer, AR-positive individuals exhibited prolonged DFS (P < 0.05). Conversely, in ER(−)/HER-2( +) and ER(−)/HER-2(−) patients with breast cancer, AR expression did not significantly influence disease-free survival (P > 0.05). Multifactorial regression analysis identified AR/ER ratio, histological classification, and lymph node metastasis as independent prognostic factors for DFS (all P < 0.05). The developed nomogram model underscored the significance of histological classification as the primary predictive factor for patient outcomes, followed by AR/ER ratio and lymph node metastasis Conclusion AR expression holds varying prognostic implications across different breast cancer subtypes, with AR positivity indicating a favorable prognosis, particularly in ER-positive tumors.https://doi.org/10.1186/s40001-025-03072-7Androgen receptorsBreast cancerAR/EREndocrine resistancePrognosis |
| spellingShingle | Menghan Cao Di Pan Yuqi Li Zicheng Pei Runbang Wang Bo Zhang Chaorong Bian Qinghao Gu Pengfei Qu Chenchen Yu Haonan Liu Zhengxiang Han Clinical significance of androgen receptor in unilateral invasive breast cancer in women European Journal of Medical Research Androgen receptors Breast cancer AR/ER Endocrine resistance Prognosis |
| title | Clinical significance of androgen receptor in unilateral invasive breast cancer in women |
| title_full | Clinical significance of androgen receptor in unilateral invasive breast cancer in women |
| title_fullStr | Clinical significance of androgen receptor in unilateral invasive breast cancer in women |
| title_full_unstemmed | Clinical significance of androgen receptor in unilateral invasive breast cancer in women |
| title_short | Clinical significance of androgen receptor in unilateral invasive breast cancer in women |
| title_sort | clinical significance of androgen receptor in unilateral invasive breast cancer in women |
| topic | Androgen receptors Breast cancer AR/ER Endocrine resistance Prognosis |
| url | https://doi.org/10.1186/s40001-025-03072-7 |
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