Risk Factors for Development and Mortality of Carbapenem-Resistant Pseudomonas aeruginosa Bloodstream Infection in a Chinese Teaching Hospital: A Seven-Year Retrospective Study
Luyan Dong,1,* Yingbin Huang,2,3,* Shengcen Zhang,1 Binbin Xu,1 Bin Li,1 Yingping Cao1 1Department of Clinical Laboratory, Fujian Medical University Union Hospital, Fuzhou, 350001, People’s Republic of China; 2Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou,...
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Dove Medical Press
2025-02-01
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| author | Dong L Huang Y Zhang S Xu B Li B Cao Y |
| author_facet | Dong L Huang Y Zhang S Xu B Li B Cao Y |
| author_sort | Dong L |
| collection | DOAJ |
| description | Luyan Dong,1,* Yingbin Huang,2,3,* Shengcen Zhang,1 Binbin Xu,1 Bin Li,1 Yingping Cao1 1Department of Clinical Laboratory, Fujian Medical University Union Hospital, Fuzhou, 350001, People’s Republic of China; 2Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, 350001, People’s Republic of China; 3The School of Pharmacy, Fujian Medical University, Fuzhou, 350004, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yingping Cao; Bin Li, Email caoyingping@aliyun.com; leonlee307@hotmail.comObjective: Pseudomonas aeruginosa (P. aeruginosa) is a gram-negative opportunistic pathogen, which can cause acute and chronic infections, often resulting in high mortality. The aim of this study was to investigate the risk factors for the development and mortality of patients with carbapenem-resistant P. aeruginosa bloodstream infection (CRPA BSI).Methods: A total of 112 patients with CRPA BSI and 112 patients with carbapenem-sensitive P. aeruginosa (CSPA) BSI were included from a Chinese teaching hospital from January 2017 to December 2023 in this retrospective cohort study. The detection rate, antimicrobial susceptibility of P. aeruginosa and clinical characteristics of these patients were investigated. Multivariable logistic regression analysis was used to identify risk factors for the development and outcomes of CRPA BSI.Results: In the past 7 years, 7480 blood samples of P. aeruginosa were cultured in the hospital. The detection rates of CRPA, multidrug resistant P. aeruginosa (MDRPA), and difficult-to-treat resistant P. aeruginosa (DTRPA) BSI increased annually (26% to 47%, 10% to 36% and 5% to 15%, respectively). CRPA showed high resistance to conventional antibiotics. Chronic lung disease (OR 3.953, 95% CI 1.131– 13.812), transplantation (OR 2.837, 95% CI 1.036– 7.770), multi-organ failure (OR 4.815, 95% CI 1.949– 11.894), pre-infection within CRPA (OR 9.239, 95% CI 3.441– 24.803), and exposure to carbapenems within 90 days (OR 2.734, 95% CI 1.052 − 7.106) were independent risk factors for the development of CRPA bacteremia. Sepsis or septic shock (OR 8.774, 95% CI 3.140– 24.515, p = 0.001) were independent risk factors of mortality.Conclusion: Chronic lung disease, transplantation, multi-organ failure, prior CRPA infection, and prior carbapenems exposure are independent risk factors for the development of CRPA bacteremia. Sepsis or septic shock increases 28-day mortality. To investigate the molecular mechanisms of carbapenem-resistance of P. aeruginosa, standardize antibiotic usage, and assess risk factors for the development and mortality of CRPA BSI are beneficial to control infection and reduce death.Keywords: Pseudomonas aeruginosa, bloodstream infection, carbapenem-resistance, risk factors, mortality |
| format | Article |
| id | doaj-art-91cc19e9a6254c79bd94de5861f07749 |
| institution | DOAJ |
| issn | 1178-6973 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Dove Medical Press |
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| series | Infection and Drug Resistance |
| spelling | doaj-art-91cc19e9a6254c79bd94de5861f077492025-08-20T02:48:42ZengDove Medical PressInfection and Drug Resistance1178-69732025-02-01Volume 18979991100313Risk Factors for Development and Mortality of Carbapenem-Resistant Pseudomonas aeruginosa Bloodstream Infection in a Chinese Teaching Hospital: A Seven-Year Retrospective StudyDong LHuang YZhang SXu BLi BCao YLuyan Dong,1,* Yingbin Huang,2,3,* Shengcen Zhang,1 Binbin Xu,1 Bin Li,1 Yingping Cao1 1Department of Clinical Laboratory, Fujian Medical University Union Hospital, Fuzhou, 350001, People’s Republic of China; 2Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, 350001, People’s Republic of China; 3The School of Pharmacy, Fujian Medical University, Fuzhou, 350004, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yingping Cao; Bin Li, Email caoyingping@aliyun.com; leonlee307@hotmail.comObjective: Pseudomonas aeruginosa (P. aeruginosa) is a gram-negative opportunistic pathogen, which can cause acute and chronic infections, often resulting in high mortality. The aim of this study was to investigate the risk factors for the development and mortality of patients with carbapenem-resistant P. aeruginosa bloodstream infection (CRPA BSI).Methods: A total of 112 patients with CRPA BSI and 112 patients with carbapenem-sensitive P. aeruginosa (CSPA) BSI were included from a Chinese teaching hospital from January 2017 to December 2023 in this retrospective cohort study. The detection rate, antimicrobial susceptibility of P. aeruginosa and clinical characteristics of these patients were investigated. Multivariable logistic regression analysis was used to identify risk factors for the development and outcomes of CRPA BSI.Results: In the past 7 years, 7480 blood samples of P. aeruginosa were cultured in the hospital. The detection rates of CRPA, multidrug resistant P. aeruginosa (MDRPA), and difficult-to-treat resistant P. aeruginosa (DTRPA) BSI increased annually (26% to 47%, 10% to 36% and 5% to 15%, respectively). CRPA showed high resistance to conventional antibiotics. Chronic lung disease (OR 3.953, 95% CI 1.131– 13.812), transplantation (OR 2.837, 95% CI 1.036– 7.770), multi-organ failure (OR 4.815, 95% CI 1.949– 11.894), pre-infection within CRPA (OR 9.239, 95% CI 3.441– 24.803), and exposure to carbapenems within 90 days (OR 2.734, 95% CI 1.052 − 7.106) were independent risk factors for the development of CRPA bacteremia. Sepsis or septic shock (OR 8.774, 95% CI 3.140– 24.515, p = 0.001) were independent risk factors of mortality.Conclusion: Chronic lung disease, transplantation, multi-organ failure, prior CRPA infection, and prior carbapenems exposure are independent risk factors for the development of CRPA bacteremia. Sepsis or septic shock increases 28-day mortality. To investigate the molecular mechanisms of carbapenem-resistance of P. aeruginosa, standardize antibiotic usage, and assess risk factors for the development and mortality of CRPA BSI are beneficial to control infection and reduce death.Keywords: Pseudomonas aeruginosa, bloodstream infection, carbapenem-resistance, risk factors, mortalityhttps://www.dovepress.com/risk-factors-for-development-and-mortality-of-carbapenem-resistant-pse-peer-reviewed-fulltext-article-IDRpseudomonas aeruginosabloodstream infectioncarbapenem-resistancerisk factorsmortality |
| spellingShingle | Dong L Huang Y Zhang S Xu B Li B Cao Y Risk Factors for Development and Mortality of Carbapenem-Resistant Pseudomonas aeruginosa Bloodstream Infection in a Chinese Teaching Hospital: A Seven-Year Retrospective Study Infection and Drug Resistance pseudomonas aeruginosa bloodstream infection carbapenem-resistance risk factors mortality |
| title | Risk Factors for Development and Mortality of Carbapenem-Resistant Pseudomonas aeruginosa Bloodstream Infection in a Chinese Teaching Hospital: A Seven-Year Retrospective Study |
| title_full | Risk Factors for Development and Mortality of Carbapenem-Resistant Pseudomonas aeruginosa Bloodstream Infection in a Chinese Teaching Hospital: A Seven-Year Retrospective Study |
| title_fullStr | Risk Factors for Development and Mortality of Carbapenem-Resistant Pseudomonas aeruginosa Bloodstream Infection in a Chinese Teaching Hospital: A Seven-Year Retrospective Study |
| title_full_unstemmed | Risk Factors for Development and Mortality of Carbapenem-Resistant Pseudomonas aeruginosa Bloodstream Infection in a Chinese Teaching Hospital: A Seven-Year Retrospective Study |
| title_short | Risk Factors for Development and Mortality of Carbapenem-Resistant Pseudomonas aeruginosa Bloodstream Infection in a Chinese Teaching Hospital: A Seven-Year Retrospective Study |
| title_sort | risk factors for development and mortality of carbapenem resistant pseudomonas aeruginosa bloodstream infection in nbsp a nbsp chinese teaching hospital a seven year retrospective study |
| topic | pseudomonas aeruginosa bloodstream infection carbapenem-resistance risk factors mortality |
| url | https://www.dovepress.com/risk-factors-for-development-and-mortality-of-carbapenem-resistant-pse-peer-reviewed-fulltext-article-IDR |
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