Research progress on lactylation in atherosclerosis
Atherosclerosis (AS) serves as the primary pathological basis for cardiovascular and cerebrovascular diseases. Lactylation, a novel post-translational modification (PTM) linked to lactate molecules, functions as a critical interface between cellular metabolism and epigenetic regulation. This modific...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Guangxi Medical University
2025-04-01
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| Series: | Guangxi Yike Daxue xuebao |
| Subjects: | |
| Online Access: | https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2025.02.019 |
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| author | MO Qin LAN Yining QIN Chao |
| author_facet | MO Qin LAN Yining QIN Chao |
| author_sort | MO Qin |
| collection | DOAJ |
| description | Atherosclerosis (AS) serves as the primary pathological basis for cardiovascular and cerebrovascular diseases. Lactylation, a novel post-translational modification (PTM) linked to lactate molecules, functions as a critical interface between cellular metabolism and epigenetic regulation. This modification influences diverse pathways to regulate essential biological processes and has been closely associated with disease progression. Emerging evidence suggests that lactylation may participate in the pathogenesis of AS. This paper aims to summarize the biological characteristics of lactylation, and then specifically emphasizes the mechanisms by which lactylation participates in the development of AS through regulating endothelial cell function, macrophage polarization, and smooth muscle cell senescence. |
| format | Article |
| id | doaj-art-91c87f7f235247138991fe3620c5e8a1 |
| institution | Kabale University |
| issn | 1005-930X |
| language | zho |
| publishDate | 2025-04-01 |
| publisher | Editorial Office of Journal of Guangxi Medical University |
| record_format | Article |
| series | Guangxi Yike Daxue xuebao |
| spelling | doaj-art-91c87f7f235247138991fe3620c5e8a12025-08-20T03:52:48ZzhoEditorial Office of Journal of Guangxi Medical UniversityGuangxi Yike Daxue xuebao1005-930X2025-04-0142230430810.16190/j.cnki.45-1211/r.2025.02.019gxykdxxb-42-2-304Research progress on lactylation in atherosclerosisMO Qin0LAN Yining1QIN Chao2Nanning First People's Hospital, Nanning 530021, ChinaThe First Affiliated Hospital of Guangxi Medical University, Nanning 530021, ChinaThe First Affiliated Hospital of Guangxi Medical University, Nanning 530021, ChinaAtherosclerosis (AS) serves as the primary pathological basis for cardiovascular and cerebrovascular diseases. Lactylation, a novel post-translational modification (PTM) linked to lactate molecules, functions as a critical interface between cellular metabolism and epigenetic regulation. This modification influences diverse pathways to regulate essential biological processes and has been closely associated with disease progression. Emerging evidence suggests that lactylation may participate in the pathogenesis of AS. This paper aims to summarize the biological characteristics of lactylation, and then specifically emphasizes the mechanisms by which lactylation participates in the development of AS through regulating endothelial cell function, macrophage polarization, and smooth muscle cell senescence.https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2025.02.019atherosclerosislactylationcardiovascular and cerebrovascular diseases |
| spellingShingle | MO Qin LAN Yining QIN Chao Research progress on lactylation in atherosclerosis Guangxi Yike Daxue xuebao atherosclerosis lactylation cardiovascular and cerebrovascular diseases |
| title | Research progress on lactylation in atherosclerosis |
| title_full | Research progress on lactylation in atherosclerosis |
| title_fullStr | Research progress on lactylation in atherosclerosis |
| title_full_unstemmed | Research progress on lactylation in atherosclerosis |
| title_short | Research progress on lactylation in atherosclerosis |
| title_sort | research progress on lactylation in atherosclerosis |
| topic | atherosclerosis lactylation cardiovascular and cerebrovascular diseases |
| url | https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2025.02.019 |
| work_keys_str_mv | AT moqin researchprogressonlactylationinatherosclerosis AT lanyining researchprogressonlactylationinatherosclerosis AT qinchao researchprogressonlactylationinatherosclerosis |