Gut hormones, appetite suppression and cachexia in patients with pulmonary TB.
<h4>Background</h4>Cachexia is a hallmark of pulmonary tuberculosis and is associated with poor prognosis. A better understanding of the mechanisms behind such weight loss could reveal targets for therapeutic intervention. The role of appetite-regulatory hormones in tuberculosis is unkno...
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0054564&type=printable |
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| author | Suzanne W Chang William S Pan Daniel Lozano Beltran Lizet Oleyda Baldelomar Marco Antonio Solano Iskra Tuero Jon S Friedland Faustino Torrico Robert H Gilman |
| author_facet | Suzanne W Chang William S Pan Daniel Lozano Beltran Lizet Oleyda Baldelomar Marco Antonio Solano Iskra Tuero Jon S Friedland Faustino Torrico Robert H Gilman |
| author_sort | Suzanne W Chang |
| collection | DOAJ |
| description | <h4>Background</h4>Cachexia is a hallmark of pulmonary tuberculosis and is associated with poor prognosis. A better understanding of the mechanisms behind such weight loss could reveal targets for therapeutic intervention. The role of appetite-regulatory hormones in tuberculosis is unknown.<h4>Methods and findings</h4>41 subjects with newly-diagnosed pulmonary TB (cases) were compared to 82 healthy controls. We measured appetite, body mass index (BMI), % body fat (BF), plasma peptide YY (PYY), leptin, ghrelin, and resistin for all subjects. Measurements were taken at baseline for controls and at treatment days 0, 30, and 60 for cases. Baseline appetite, BMI, and BF were lower in cases than in controls and improved during treatment. PYY, ghrelin, and resistin were significantly elevated in cases and fell during treatment. Leptin was lower in cases and rose with treatment. Appetite was inversely related to PYY in cases. High pre-treatment PYY predicted reduced gains in appetite and BF. PYY was the strongest independent predictor of appetite in cases across all time points.<h4>Conclusions</h4>Appetite-regulatory hormones are altered in TB patients. As hormones normalize during treatment, appetite is restored and nutritional status improves. High baseline PYY is an indicator of poor prognosis for improvement in appetite and nutrition during treatment. Wasting in TB patients may partly be mediated by upregulation of PYY with resulting appetite suppression. |
| format | Article |
| id | doaj-art-91c846a6eb8542f9815ca93de3717a56 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-91c846a6eb8542f9815ca93de3717a562025-08-20T02:30:38ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0181e5456410.1371/journal.pone.0054564Gut hormones, appetite suppression and cachexia in patients with pulmonary TB.Suzanne W ChangWilliam S PanDaniel Lozano BeltranLizet Oleyda BaldelomarMarco Antonio SolanoIskra TueroJon S FriedlandFaustino TorricoRobert H Gilman<h4>Background</h4>Cachexia is a hallmark of pulmonary tuberculosis and is associated with poor prognosis. A better understanding of the mechanisms behind such weight loss could reveal targets for therapeutic intervention. The role of appetite-regulatory hormones in tuberculosis is unknown.<h4>Methods and findings</h4>41 subjects with newly-diagnosed pulmonary TB (cases) were compared to 82 healthy controls. We measured appetite, body mass index (BMI), % body fat (BF), plasma peptide YY (PYY), leptin, ghrelin, and resistin for all subjects. Measurements were taken at baseline for controls and at treatment days 0, 30, and 60 for cases. Baseline appetite, BMI, and BF were lower in cases than in controls and improved during treatment. PYY, ghrelin, and resistin were significantly elevated in cases and fell during treatment. Leptin was lower in cases and rose with treatment. Appetite was inversely related to PYY in cases. High pre-treatment PYY predicted reduced gains in appetite and BF. PYY was the strongest independent predictor of appetite in cases across all time points.<h4>Conclusions</h4>Appetite-regulatory hormones are altered in TB patients. As hormones normalize during treatment, appetite is restored and nutritional status improves. High baseline PYY is an indicator of poor prognosis for improvement in appetite and nutrition during treatment. Wasting in TB patients may partly be mediated by upregulation of PYY with resulting appetite suppression.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0054564&type=printable |
| spellingShingle | Suzanne W Chang William S Pan Daniel Lozano Beltran Lizet Oleyda Baldelomar Marco Antonio Solano Iskra Tuero Jon S Friedland Faustino Torrico Robert H Gilman Gut hormones, appetite suppression and cachexia in patients with pulmonary TB. PLoS ONE |
| title | Gut hormones, appetite suppression and cachexia in patients with pulmonary TB. |
| title_full | Gut hormones, appetite suppression and cachexia in patients with pulmonary TB. |
| title_fullStr | Gut hormones, appetite suppression and cachexia in patients with pulmonary TB. |
| title_full_unstemmed | Gut hormones, appetite suppression and cachexia in patients with pulmonary TB. |
| title_short | Gut hormones, appetite suppression and cachexia in patients with pulmonary TB. |
| title_sort | gut hormones appetite suppression and cachexia in patients with pulmonary tb |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0054564&type=printable |
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