Malignancies in people living with HIV: A 25-years observational study from a tertiary hospital in Italy
Background: HIV infection has been associated with an increased risk of cancer development and Kaposi’s sarcoma, non-Hodgkin’s lymphoma, and invasive cervical cancers have been a manifestation of AIDS. With the advent of antiretroviral therapy, a collateral appearance of non-AIDS defining cancers (N...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Journal of Infection and Public Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034125000103 |
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| author | Antonio Anastasia Walter Mazzucco Luca Pipitò Santo Fruscione Roberta Gaudiano Marcello Trizzino Maurizio Zarcone Antonio Cascio |
| author_facet | Antonio Anastasia Walter Mazzucco Luca Pipitò Santo Fruscione Roberta Gaudiano Marcello Trizzino Maurizio Zarcone Antonio Cascio |
| author_sort | Antonio Anastasia |
| collection | DOAJ |
| description | Background: HIV infection has been associated with an increased risk of cancer development and Kaposi’s sarcoma, non-Hodgkin’s lymphoma, and invasive cervical cancers have been a manifestation of AIDS. With the advent of antiretroviral therapy, a collateral appearance of non-AIDS defining cancers (NADC) has been observed in HIV positive patients. Methods: From January 1997 to December 2022, we performed an observational cross-sectional study, involving HIV-infected outpatients with both AIDS-defining cancers (ADC) and NADC, followed up in a tertiary hospital in Italy. Results: Overall, 153 cases of malignancy were observed, with a higher percentage of NADC (60.8 %) rather than ADC (39.2 %). Mean age at tumour diagnosis was significantly lower for ADC than for NADC in HIV positive individuals (p-value= 0.001). No statistical difference was found between the mean values of zenith HIV-RNA and CD4 count in HIV outpatients with cancer and in those without cancer, while a statistically significant difference was found between the HIV-RNA zenith in HIV outpatients with ADC as compared with NADC (10.2 copies/mL versus 8.1 copies/mL; p-value= 0.007). Conclusions: Our study revealed a considerably high proportion of non-AIDS defining malignancies in HIV individuals, emphasizing the need to improve the management of these cancer patients at follow up according to the risk profiles and the changing epidemiology. |
| format | Article |
| id | doaj-art-91c766191f5540318bba8146b381d52c |
| institution | Kabale University |
| issn | 1876-0341 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj-art-91c766191f5540318bba8146b381d52c2025-01-21T04:12:59ZengElsevierJournal of Infection and Public Health1876-03412025-02-01182102661Malignancies in people living with HIV: A 25-years observational study from a tertiary hospital in ItalyAntonio Anastasia0Walter Mazzucco1Luca Pipitò2Santo Fruscione3Roberta Gaudiano4Marcello Trizzino5Maurizio Zarcone6Antonio Cascio7Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties ''G D′Alessandro,'' University of Palermo, Palermo, Italy; Infectious and Tropical Disease Unit and Sicilian Regional Reference Center for the fight against AIDS, AOU Policlinico ''P. Giaccone'', Palermo, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties ''G D′Alessandro,'' University of Palermo, Palermo, Italy; Clinical Epidemiology and Cancer Registry Unit, AOU Policlinico ''P. Giaccone'', Palermo, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties ''G D′Alessandro,'' University of Palermo, Palermo, Italy; Infectious and Tropical Disease Unit and Sicilian Regional Reference Center for the fight against AIDS, AOU Policlinico ''P. Giaccone'', Palermo, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties ''G D′Alessandro,'' University of Palermo, Palermo, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties ''G D′Alessandro,'' University of Palermo, Palermo, Italy; Infectious and Tropical Disease Unit and Sicilian Regional Reference Center for the fight against AIDS, AOU Policlinico ''P. Giaccone'', Palermo, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties ''G D′Alessandro,'' University of Palermo, Palermo, Italy; Infectious and Tropical Disease Unit and Sicilian Regional Reference Center for the fight against AIDS, AOU Policlinico ''P. Giaccone'', Palermo, ItalyClinical Epidemiology and Cancer Registry Unit, AOU Policlinico ''P. Giaccone'', Palermo, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties ''G D′Alessandro,'' University of Palermo, Palermo, Italy; Infectious and Tropical Disease Unit and Sicilian Regional Reference Center for the fight against AIDS, AOU Policlinico ''P. Giaccone'', Palermo, Italy; Corresponding author at: Infectious and Tropical Disease Unit, AOU Policlinico “P. Giaccone”, Via del Vespro 129, Palermo 90127, Italy.Background: HIV infection has been associated with an increased risk of cancer development and Kaposi’s sarcoma, non-Hodgkin’s lymphoma, and invasive cervical cancers have been a manifestation of AIDS. With the advent of antiretroviral therapy, a collateral appearance of non-AIDS defining cancers (NADC) has been observed in HIV positive patients. Methods: From January 1997 to December 2022, we performed an observational cross-sectional study, involving HIV-infected outpatients with both AIDS-defining cancers (ADC) and NADC, followed up in a tertiary hospital in Italy. Results: Overall, 153 cases of malignancy were observed, with a higher percentage of NADC (60.8 %) rather than ADC (39.2 %). Mean age at tumour diagnosis was significantly lower for ADC than for NADC in HIV positive individuals (p-value= 0.001). No statistical difference was found between the mean values of zenith HIV-RNA and CD4 count in HIV outpatients with cancer and in those without cancer, while a statistically significant difference was found between the HIV-RNA zenith in HIV outpatients with ADC as compared with NADC (10.2 copies/mL versus 8.1 copies/mL; p-value= 0.007). Conclusions: Our study revealed a considerably high proportion of non-AIDS defining malignancies in HIV individuals, emphasizing the need to improve the management of these cancer patients at follow up according to the risk profiles and the changing epidemiology.http://www.sciencedirect.com/science/article/pii/S1876034125000103HIV-1Cancer epidemiologyAIDS defining cancerNon-AIDS defining cancer |
| spellingShingle | Antonio Anastasia Walter Mazzucco Luca Pipitò Santo Fruscione Roberta Gaudiano Marcello Trizzino Maurizio Zarcone Antonio Cascio Malignancies in people living with HIV: A 25-years observational study from a tertiary hospital in Italy Journal of Infection and Public Health HIV-1 Cancer epidemiology AIDS defining cancer Non-AIDS defining cancer |
| title | Malignancies in people living with HIV: A 25-years observational study from a tertiary hospital in Italy |
| title_full | Malignancies in people living with HIV: A 25-years observational study from a tertiary hospital in Italy |
| title_fullStr | Malignancies in people living with HIV: A 25-years observational study from a tertiary hospital in Italy |
| title_full_unstemmed | Malignancies in people living with HIV: A 25-years observational study from a tertiary hospital in Italy |
| title_short | Malignancies in people living with HIV: A 25-years observational study from a tertiary hospital in Italy |
| title_sort | malignancies in people living with hiv a 25 years observational study from a tertiary hospital in italy |
| topic | HIV-1 Cancer epidemiology AIDS defining cancer Non-AIDS defining cancer |
| url | http://www.sciencedirect.com/science/article/pii/S1876034125000103 |
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