The Effects of Exercise Training on Obesity-Induced Dysregulated Expression of Adipokines in White Adipose Tissue
Obesity is recognized as a risk factor for lifestyle-related diseases such as type 2 diabetes and cardiovascular disease. White adipose tissue (WAT) is not only a static storage site for energy; it is also a dynamic tissue that is actively involved in metabolic reactions and produces humoral factors...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/801743 |
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| author | Takuya Sakurai Junetsu Ogasawara Takako Kizaki Shogo Sato Yoshinaga Ishibashi Motoko Takahashi Osamu Kobayashi Shuji Oh-ishi Junichi Nagasawa Kazuto Takahashi Hitoshi Ishida Tetsuya Izawa Hideki Ohno |
| author_facet | Takuya Sakurai Junetsu Ogasawara Takako Kizaki Shogo Sato Yoshinaga Ishibashi Motoko Takahashi Osamu Kobayashi Shuji Oh-ishi Junichi Nagasawa Kazuto Takahashi Hitoshi Ishida Tetsuya Izawa Hideki Ohno |
| author_sort | Takuya Sakurai |
| collection | DOAJ |
| description | Obesity is recognized as a risk factor for lifestyle-related diseases such as type 2 diabetes and cardiovascular disease. White adipose tissue (WAT) is not only a static storage site for energy; it is also a dynamic tissue that is actively involved in metabolic reactions and produces humoral factors, such as leptin and adiponectin, which are collectively referred to as adipokines. Additionally, because there is much evidence that obesity-induced inflammatory changes in WAT, which is caused by dysregulated expression of inflammation-related adipokines involving tumor necrosis factor-α and monocyte chemoattractant protein 1, contribute to the development of insulin resistance, WAT has attracted special attention as an organ that causes diabetes and other lifestyle-related diseases. Exercise training (TR) not only leads to a decrease in WAT mass but also attenuates obesity-induced dysregulated expression of the inflammation-related adipokines in WAT. Therefore, TR is widely used as a tool for preventing and improving lifestyle-related diseases. This review outlines the impact of TR on the expression and secretory response of adipokines in WAT. |
| format | Article |
| id | doaj-art-91c57ad5ff454881b0b0cda04a934f23 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-91c57ad5ff454881b0b0cda04a934f232025-08-20T03:37:06ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/801743801743The Effects of Exercise Training on Obesity-Induced Dysregulated Expression of Adipokines in White Adipose TissueTakuya Sakurai0Junetsu Ogasawara1Takako Kizaki2Shogo Sato3Yoshinaga Ishibashi4Motoko Takahashi5Osamu Kobayashi6Shuji Oh-ishi7Junichi Nagasawa8Kazuto Takahashi9Hitoshi Ishida10Tetsuya Izawa11Hideki Ohno12Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, JapanDepartment of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, JapanDepartment of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, JapanDepartment of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, JapanDepartment of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, JapanDepartment of Biochemistry, Sapporo Medical University School of Medicine, South-1 West-17, Chuo-ku, Sapporo, Hokkaido 060-8556, JapanDepartment of Nursing, Kyorin University, Faculty of Health Science, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, JapanDepartment of Respiratory Medicine, Hachioji Medical Center, Tokyo Medical University, 1163 Tatemachi, Hachioji, Tokyo 193-0998, JapanDepartment of Applied Physics and Chemistry, The University of Electro-Communications, 1-5-1 Chofugaoka, Chofu, Tokyo 182-8585, JapanThird Department of Internal Medicine, Kyorin University, School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, JapanThird Department of Internal Medicine, Kyorin University, School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, JapanDepartment of Sports Biochemistry, Faculty of Health and Sport Science, Doshisha University, 1-3 Tatara Miyakodani, Kyotanabe, Kyoto 610-0394, JapanDepartment of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, JapanObesity is recognized as a risk factor for lifestyle-related diseases such as type 2 diabetes and cardiovascular disease. White adipose tissue (WAT) is not only a static storage site for energy; it is also a dynamic tissue that is actively involved in metabolic reactions and produces humoral factors, such as leptin and adiponectin, which are collectively referred to as adipokines. Additionally, because there is much evidence that obesity-induced inflammatory changes in WAT, which is caused by dysregulated expression of inflammation-related adipokines involving tumor necrosis factor-α and monocyte chemoattractant protein 1, contribute to the development of insulin resistance, WAT has attracted special attention as an organ that causes diabetes and other lifestyle-related diseases. Exercise training (TR) not only leads to a decrease in WAT mass but also attenuates obesity-induced dysregulated expression of the inflammation-related adipokines in WAT. Therefore, TR is widely used as a tool for preventing and improving lifestyle-related diseases. This review outlines the impact of TR on the expression and secretory response of adipokines in WAT.http://dx.doi.org/10.1155/2013/801743 |
| spellingShingle | Takuya Sakurai Junetsu Ogasawara Takako Kizaki Shogo Sato Yoshinaga Ishibashi Motoko Takahashi Osamu Kobayashi Shuji Oh-ishi Junichi Nagasawa Kazuto Takahashi Hitoshi Ishida Tetsuya Izawa Hideki Ohno The Effects of Exercise Training on Obesity-Induced Dysregulated Expression of Adipokines in White Adipose Tissue International Journal of Endocrinology |
| title | The Effects of Exercise Training on Obesity-Induced Dysregulated Expression of Adipokines in White Adipose Tissue |
| title_full | The Effects of Exercise Training on Obesity-Induced Dysregulated Expression of Adipokines in White Adipose Tissue |
| title_fullStr | The Effects of Exercise Training on Obesity-Induced Dysregulated Expression of Adipokines in White Adipose Tissue |
| title_full_unstemmed | The Effects of Exercise Training on Obesity-Induced Dysregulated Expression of Adipokines in White Adipose Tissue |
| title_short | The Effects of Exercise Training on Obesity-Induced Dysregulated Expression of Adipokines in White Adipose Tissue |
| title_sort | effects of exercise training on obesity induced dysregulated expression of adipokines in white adipose tissue |
| url | http://dx.doi.org/10.1155/2013/801743 |
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