Understanding the complex role of exosomes in intestinal ischemia-reperfusion injury: from pathogenesis to protection
Extracellular vesicles, which are predominantly classified into ectosomes and exosomes, are released by all cells under both physiological conditions and in response to acquired pathological states. Exosomes demonstrate multifaceted functions: they regulate cellular homeostasis through the eliminati...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1533628/full |
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| author | Qin Ye Zi-Hang Yu Liang Nie Fei-Xiang Wang Guo Mu Bin Lu |
| author_facet | Qin Ye Zi-Hang Yu Liang Nie Fei-Xiang Wang Guo Mu Bin Lu |
| author_sort | Qin Ye |
| collection | DOAJ |
| description | Extracellular vesicles, which are predominantly classified into ectosomes and exosomes, are released by all cells under both physiological conditions and in response to acquired pathological states. Exosomes demonstrate multifaceted functions: they regulate cellular homeostasis through the elimination of redundant or detrimental intracellular components, function as mediators in intercellular signaling pathways, and serve as potential vectors for both diagnostic and therapeutic applications. Intestinal ischemia-reperfusion injury (IRI), a prevalent form of tissue and organ injury in surgical settings, has been extensively investigated. Emerging evidence indicates a crucial relationship between exosomes and intestinal IRI, specifically regarding how exosomes derived from either intestinal tissue or distant organs can modulate the pathophysiological progression of intestinal IRI. This review systematically evaluates the mechanistic roles of exosomes in intestinal IRI and their involvement in post-intestinal IRI multiple organ dysfunction, aiming to establish a theoretical foundation for therapeutic interventions and future research directions. |
| format | Article |
| id | doaj-art-91c4fd5ea3e143728d8a7cc3a66083ea |
| institution | OA Journals |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-91c4fd5ea3e143728d8a7cc3a66083ea2025-08-20T02:16:11ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-04-011610.3389/fphar.2025.15336281533628Understanding the complex role of exosomes in intestinal ischemia-reperfusion injury: from pathogenesis to protectionQin Ye0Zi-Hang Yu1Liang Nie2Fei-Xiang Wang3Guo Mu4Bin Lu5Department of Anesthesiology, Zigong Fourth People’s Hospital, Zigong, Sichuan, ChinaDepartment of Anesthesiology, Fushun County People’s Hospital, Zigong, Sichuan, ChinaDepartment of Anesthesiology, Fushun County People’s Hospital, Zigong, Sichuan, ChinaDepartment of Anesthesiology, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Anesthesiology, Zigong Fourth People’s Hospital, Zigong, Sichuan, ChinaDepartment of Anesthesiology, Zigong Fourth People’s Hospital, Zigong, Sichuan, ChinaExtracellular vesicles, which are predominantly classified into ectosomes and exosomes, are released by all cells under both physiological conditions and in response to acquired pathological states. Exosomes demonstrate multifaceted functions: they regulate cellular homeostasis through the elimination of redundant or detrimental intracellular components, function as mediators in intercellular signaling pathways, and serve as potential vectors for both diagnostic and therapeutic applications. Intestinal ischemia-reperfusion injury (IRI), a prevalent form of tissue and organ injury in surgical settings, has been extensively investigated. Emerging evidence indicates a crucial relationship between exosomes and intestinal IRI, specifically regarding how exosomes derived from either intestinal tissue or distant organs can modulate the pathophysiological progression of intestinal IRI. This review systematically evaluates the mechanistic roles of exosomes in intestinal IRI and their involvement in post-intestinal IRI multiple organ dysfunction, aiming to establish a theoretical foundation for therapeutic interventions and future research directions.https://www.frontiersin.org/articles/10.3389/fphar.2025.1533628/fullexosomesischemia-reperfusion injuryintestinal ischemia-reperfusion injuryintestinal injurymultiorgan injury |
| spellingShingle | Qin Ye Zi-Hang Yu Liang Nie Fei-Xiang Wang Guo Mu Bin Lu Understanding the complex role of exosomes in intestinal ischemia-reperfusion injury: from pathogenesis to protection Frontiers in Pharmacology exosomes ischemia-reperfusion injury intestinal ischemia-reperfusion injury intestinal injury multiorgan injury |
| title | Understanding the complex role of exosomes in intestinal ischemia-reperfusion injury: from pathogenesis to protection |
| title_full | Understanding the complex role of exosomes in intestinal ischemia-reperfusion injury: from pathogenesis to protection |
| title_fullStr | Understanding the complex role of exosomes in intestinal ischemia-reperfusion injury: from pathogenesis to protection |
| title_full_unstemmed | Understanding the complex role of exosomes in intestinal ischemia-reperfusion injury: from pathogenesis to protection |
| title_short | Understanding the complex role of exosomes in intestinal ischemia-reperfusion injury: from pathogenesis to protection |
| title_sort | understanding the complex role of exosomes in intestinal ischemia reperfusion injury from pathogenesis to protection |
| topic | exosomes ischemia-reperfusion injury intestinal ischemia-reperfusion injury intestinal injury multiorgan injury |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1533628/full |
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