HDL-bound S1P affects the subventricular niche and early neuropathological features of Alzheimer’s disease

HDL-bound S1P affects the subventricular niche and early neuropathological features of Alzheimer’s disease

Abstract Circulating blood factors are critical for homeostasis of the adult ventricular-subventricular (V-SVZ) and subgranular zones, which contain neural stem cells (NSCs) crucial for sustained neurogenesis. Circulating sphingosine-1-phosphate (S1P) bound to apolipoprotein M (ApoM), a principal co...

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Main Authors: Byung Jo Choi, Ju Yeon Hong, Min Hee Park, Kang Ho Park, Wan Hui Han, Hee Ji Yoon, Hye Yoon Jung, Kyung Yeol Kim, Sun Ae Lee, Eun Young Lim, Jung Woo Hur, Im-Sook Song, So Yeon Jeon, Min-Koo Choi, Christina Christoffersen, Hee-Jin Kim, Seung Hyun Kim, Edward H. Schuchman, Jae-sung Bae, Hee Kyung Jin
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60750-0
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