Regulation of anti-tumour effects of Paris polyphylla saponins via ROS: molecular mechanisms and therapeutic potentials

Regulation of anti-tumour effects of Paris polyphylla saponins via ROS: molecular mechanisms and therapeutic potentials

Reactive oxygen species (ROS) exhibit a dual regulatory role in cancer biology. While moderate ROS levels promote tumorigenesis via DNA mutagenesis, excessive ROS accumulation induces cancer cell death through oxidative stress. Therefore, ROS homeostasis represents a promising therapeutic target in...

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Bibliographic Details
Main Authors: Jia Liu, Yongping Mu, Ke Qi, Jiayi Li, Yang Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
Paris polyphylla
reactive oxygen species
anti-cancer
mechanism
saponins
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1611911/full
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