Mitochondrial Dysfunction in Endothelial Cells: A Key Driver of Organ Disorders and Aging
Mitochondria are of great importance in cell biology since they are major sites of adenosine triphosphate (ATP) production and are widely involved in different cellular pathways involved in the response to stress. During ATP production, reactive oxygen species (ROS) can be produced. While a small am...
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| Format: | Article |
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MDPI AG
2025-03-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/14/4/372 |
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| author | Elena Grossini Sakthipriyan Venkatesan Mohammad Mostafa Ola Pour |
| author_facet | Elena Grossini Sakthipriyan Venkatesan Mohammad Mostafa Ola Pour |
| author_sort | Elena Grossini |
| collection | DOAJ |
| description | Mitochondria are of great importance in cell biology since they are major sites of adenosine triphosphate (ATP) production and are widely involved in different cellular pathways involved in the response to stress. During ATP production, reactive oxygen species (ROS) can be produced. While a small amount of ROS may be important for the regulation of physiological processes, at elevated levels they can turn into harmful agents leading to cellular damage. From a pathological perspective, it could be particularly interesting to focus on mitochondrial function in endothelial cells since they may be involved in the development of aging and in the onset of different diseases, including renal, cardio-metabolic, liver and neurodegenerative ones. However, to date, there are no surveys which address the above issues. To fill this gap, it may be valuable to collect recent findings about the role of mitochondria in the regulation of endothelial function, not only to increase knowledge about it but also for clinical applications. Here, we overview the most recent knowledge about the above issues in the view of characterizing the role of mitochondria in endothelial cells as an innovative potential target for the prevention of aging, as well as the treatment of the above pathological conditions. |
| format | Article |
| id | doaj-art-91bf049d781045aebcc86f7851ab16a2 |
| institution | OA Journals |
| issn | 2076-3921 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-91bf049d781045aebcc86f7851ab16a22025-08-20T02:24:39ZengMDPI AGAntioxidants2076-39212025-03-0114437210.3390/antiox14040372Mitochondrial Dysfunction in Endothelial Cells: A Key Driver of Organ Disorders and AgingElena Grossini0Sakthipriyan Venkatesan1Mohammad Mostafa Ola Pour2Laboratory of Physiology, Department of Translational Medicine, Università del Piemonte Orientale, 28100 Novara, ItalyLaboratory of Physiology, Department of Translational Medicine, Università del Piemonte Orientale, 28100 Novara, ItalyLaboratory of Physiology, Department of Translational Medicine, Università del Piemonte Orientale, 28100 Novara, ItalyMitochondria are of great importance in cell biology since they are major sites of adenosine triphosphate (ATP) production and are widely involved in different cellular pathways involved in the response to stress. During ATP production, reactive oxygen species (ROS) can be produced. While a small amount of ROS may be important for the regulation of physiological processes, at elevated levels they can turn into harmful agents leading to cellular damage. From a pathological perspective, it could be particularly interesting to focus on mitochondrial function in endothelial cells since they may be involved in the development of aging and in the onset of different diseases, including renal, cardio-metabolic, liver and neurodegenerative ones. However, to date, there are no surveys which address the above issues. To fill this gap, it may be valuable to collect recent findings about the role of mitochondria in the regulation of endothelial function, not only to increase knowledge about it but also for clinical applications. Here, we overview the most recent knowledge about the above issues in the view of characterizing the role of mitochondria in endothelial cells as an innovative potential target for the prevention of aging, as well as the treatment of the above pathological conditions.https://www.mdpi.com/2076-3921/14/4/372ageingendothelial cellsmitochondrialiver diseasesneurodegenerative disordersrenal diseases |
| spellingShingle | Elena Grossini Sakthipriyan Venkatesan Mohammad Mostafa Ola Pour Mitochondrial Dysfunction in Endothelial Cells: A Key Driver of Organ Disorders and Aging Antioxidants ageing endothelial cells mitochondria liver diseases neurodegenerative disorders renal diseases |
| title | Mitochondrial Dysfunction in Endothelial Cells: A Key Driver of Organ Disorders and Aging |
| title_full | Mitochondrial Dysfunction in Endothelial Cells: A Key Driver of Organ Disorders and Aging |
| title_fullStr | Mitochondrial Dysfunction in Endothelial Cells: A Key Driver of Organ Disorders and Aging |
| title_full_unstemmed | Mitochondrial Dysfunction in Endothelial Cells: A Key Driver of Organ Disorders and Aging |
| title_short | Mitochondrial Dysfunction in Endothelial Cells: A Key Driver of Organ Disorders and Aging |
| title_sort | mitochondrial dysfunction in endothelial cells a key driver of organ disorders and aging |
| topic | ageing endothelial cells mitochondria liver diseases neurodegenerative disorders renal diseases |
| url | https://www.mdpi.com/2076-3921/14/4/372 |
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