Retinal vessel density using optical coherence tomography angiography as a potential biomarker in patients with cerebral small vessel disease
Abstract Background Optical coherence tomography angiography (OCTA) is a quick, noninvasive modality that visualizes retinal microvasculature. The retina is known to be the mirror of the brain, thus it is pertinent to employ OCTA to study covert cerebral small vessel disease (CSVD). Methods This is...
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| Format: | Article |
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SpringerOpen
2025-05-01
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| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
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| Online Access: | https://doi.org/10.1186/s41983-025-00973-6 |
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| author | Nevine El Nahas Tamer Roushdy Mona Wahid el din Mona Abdellatif Sara Gaber Weam Ebeid Hossam Shokri |
| author_facet | Nevine El Nahas Tamer Roushdy Mona Wahid el din Mona Abdellatif Sara Gaber Weam Ebeid Hossam Shokri |
| author_sort | Nevine El Nahas |
| collection | DOAJ |
| description | Abstract Background Optical coherence tomography angiography (OCTA) is a quick, noninvasive modality that visualizes retinal microvasculature. The retina is known to be the mirror of the brain, thus it is pertinent to employ OCTA to study covert cerebral small vessel disease (CSVD). Methods This is an observational case–control study of 40 patients with CSVD and 20 healthy controls. Mini-mental state examination (MMSE) was performed for all subjects, to exclude dementia. Fazekas grading and SVD score were determined by MRI. OCTA was performed for both groups and included various parameters of superficial and deep retinal capillary plexus density, macular, foveal and ganglion cell complex thickness, in addition to optic nerve head scans. Results Seventy percent of the patients had a low SVD score (1). Case group had significantly lower scores on most parameters of retinal capillary plexus density and macular thickness p < 0.05. Impairment of OCTA parameters was associated with higher Fazekas and SVD scores. Conclusion OCTA is a handy, noninvasive tool that enables the visualization of diminished retinal microvascular density in cases of early CSVD. It can serve as a screening tool for identifying vulnerable populations, facilitating early management for CSVD. |
| format | Article |
| id | doaj-art-91be7b2461534e7b906c42b0d55dcf6e |
| institution | OA Journals |
| issn | 1687-8329 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | SpringerOpen |
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| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj-art-91be7b2461534e7b906c42b0d55dcf6e2025-08-20T02:39:07ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292025-05-0161111110.1186/s41983-025-00973-6Retinal vessel density using optical coherence tomography angiography as a potential biomarker in patients with cerebral small vessel diseaseNevine El Nahas0Tamer Roushdy1Mona Wahid el din2Mona Abdellatif3Sara Gaber4Weam Ebeid5Hossam Shokri6Ain Shams UniversityAin Shams UniversityAin Shams UniversityAin Shams UniversityAin Shams UniversityAin Shams UniversityAin Shams UniversityAbstract Background Optical coherence tomography angiography (OCTA) is a quick, noninvasive modality that visualizes retinal microvasculature. The retina is known to be the mirror of the brain, thus it is pertinent to employ OCTA to study covert cerebral small vessel disease (CSVD). Methods This is an observational case–control study of 40 patients with CSVD and 20 healthy controls. Mini-mental state examination (MMSE) was performed for all subjects, to exclude dementia. Fazekas grading and SVD score were determined by MRI. OCTA was performed for both groups and included various parameters of superficial and deep retinal capillary plexus density, macular, foveal and ganglion cell complex thickness, in addition to optic nerve head scans. Results Seventy percent of the patients had a low SVD score (1). Case group had significantly lower scores on most parameters of retinal capillary plexus density and macular thickness p < 0.05. Impairment of OCTA parameters was associated with higher Fazekas and SVD scores. Conclusion OCTA is a handy, noninvasive tool that enables the visualization of diminished retinal microvascular density in cases of early CSVD. It can serve as a screening tool for identifying vulnerable populations, facilitating early management for CSVD.https://doi.org/10.1186/s41983-025-00973-6Optical coherence tomography angiographyCerebral small vessel diseaseRetinal microvasculatureDeep retinal capillary plexus density |
| spellingShingle | Nevine El Nahas Tamer Roushdy Mona Wahid el din Mona Abdellatif Sara Gaber Weam Ebeid Hossam Shokri Retinal vessel density using optical coherence tomography angiography as a potential biomarker in patients with cerebral small vessel disease The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Optical coherence tomography angiography Cerebral small vessel disease Retinal microvasculature Deep retinal capillary plexus density |
| title | Retinal vessel density using optical coherence tomography angiography as a potential biomarker in patients with cerebral small vessel disease |
| title_full | Retinal vessel density using optical coherence tomography angiography as a potential biomarker in patients with cerebral small vessel disease |
| title_fullStr | Retinal vessel density using optical coherence tomography angiography as a potential biomarker in patients with cerebral small vessel disease |
| title_full_unstemmed | Retinal vessel density using optical coherence tomography angiography as a potential biomarker in patients with cerebral small vessel disease |
| title_short | Retinal vessel density using optical coherence tomography angiography as a potential biomarker in patients with cerebral small vessel disease |
| title_sort | retinal vessel density using optical coherence tomography angiography as a potential biomarker in patients with cerebral small vessel disease |
| topic | Optical coherence tomography angiography Cerebral small vessel disease Retinal microvasculature Deep retinal capillary plexus density |
| url | https://doi.org/10.1186/s41983-025-00973-6 |
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