THE EFFICACY OF ANTIHYPERTENSIVE TREATMENT COMBINATION WITH ANXIOLYTICS IN HYPERTENSIVES WITH ANXIETY DISORDER
Aim. To compare the influence of the simple and combined with anxiolytic drug tofisopam (AT) antihypertesion therapy (AHT) on the 24-hour blood pressure (BP) profile, anxiety level and life quality of patients with uncontrolled arterial hypertension and anxiety spectrum disorder.Material and methods...
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«FIRMA «SILICEA» LLC
2017-05-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/666 |
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| author | D. V. Kovalev V. V. Skibitsky A. N. Kurzanov A. I. Ponomareva |
| author_facet | D. V. Kovalev V. V. Skibitsky A. N. Kurzanov A. I. Ponomareva |
| author_sort | D. V. Kovalev |
| collection | DOAJ |
| description | Aim. To compare the influence of the simple and combined with anxiolytic drug tofisopam (AT) antihypertesion therapy (AHT) on the 24-hour blood pressure (BP) profile, anxiety level and life quality of patients with uncontrolled arterial hypertension and anxiety spectrum disorder.Material and methods. Sixty-nine patients (mean age 48,5±5,3 y. o., 35 women) were randomized to 2 groups. Each group consequently during 1 year study received two types of medicines for 6 months each with cross-replacement: isolated AHT and combination AHT with AT (AHT+A). Group 1 (35 persons) for the 1st half year took AHT, and then following half year AHT+A; group 2 (34 persons) — in back order. At the end of every period the following parameters were controlled: ambulatory blood pressure monitoring, prominence of trait and reactive anxiety, and life quality. Also, the same comparisons were done for every group separately at the end of the first and second stages of treatment.Results. The initiation of combination AHT+A led to faster decrease of BP, achievement of lower mean daily and mean nocturnal systolic and diastolic BP, lower BP variability parameters. Only combination AHT+A showed adequate reducement of reactive anxiety. Combination and simple AHT in 6 months led to significant improvement of life quality, however combination AHT showed more significant values.Conclusion. Efficacy of combination AHT+A in hypertensive persons with anxiety disorder is higher comparing to simple AHT. |
| format | Article |
| id | doaj-art-91ba3b21ab4f4650bfc77ce82bd7816d |
| institution | DOAJ |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2017-05-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-91ba3b21ab4f4650bfc77ce82bd7816d2025-08-20T02:59:38Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202017-05-01049910410.15829/1560-4071-2017-4-99-104716THE EFFICACY OF ANTIHYPERTENSIVE TREATMENT COMBINATION WITH ANXIOLYTICS IN HYPERTENSIVES WITH ANXIETY DISORDERD. V. Kovalev0V. V. Skibitsky1A. N. Kurzanov2A. I. Ponomareva3Kuban State Medical University of the Ministry of HealthKuban State Medical University of the Ministry of HealthKuban State Medical University of the Ministry of HealthKuban State Medical University of the Ministry of HealthAim. To compare the influence of the simple and combined with anxiolytic drug tofisopam (AT) antihypertesion therapy (AHT) on the 24-hour blood pressure (BP) profile, anxiety level and life quality of patients with uncontrolled arterial hypertension and anxiety spectrum disorder.Material and methods. Sixty-nine patients (mean age 48,5±5,3 y. o., 35 women) were randomized to 2 groups. Each group consequently during 1 year study received two types of medicines for 6 months each with cross-replacement: isolated AHT and combination AHT with AT (AHT+A). Group 1 (35 persons) for the 1st half year took AHT, and then following half year AHT+A; group 2 (34 persons) — in back order. At the end of every period the following parameters were controlled: ambulatory blood pressure monitoring, prominence of trait and reactive anxiety, and life quality. Also, the same comparisons were done for every group separately at the end of the first and second stages of treatment.Results. The initiation of combination AHT+A led to faster decrease of BP, achievement of lower mean daily and mean nocturnal systolic and diastolic BP, lower BP variability parameters. Only combination AHT+A showed adequate reducement of reactive anxiety. Combination and simple AHT in 6 months led to significant improvement of life quality, however combination AHT showed more significant values.Conclusion. Efficacy of combination AHT+A in hypertensive persons with anxiety disorder is higher comparing to simple AHT.https://russjcardiol.elpub.ru/jour/article/view/666arterial hypertensionambulatory blood pressure monitoringanxietyanxiolyticstofisopam |
| spellingShingle | D. V. Kovalev V. V. Skibitsky A. N. Kurzanov A. I. Ponomareva THE EFFICACY OF ANTIHYPERTENSIVE TREATMENT COMBINATION WITH ANXIOLYTICS IN HYPERTENSIVES WITH ANXIETY DISORDER Российский кардиологический журнал arterial hypertension ambulatory blood pressure monitoring anxiety anxiolytics tofisopam |
| title | THE EFFICACY OF ANTIHYPERTENSIVE TREATMENT COMBINATION WITH ANXIOLYTICS IN HYPERTENSIVES WITH ANXIETY DISORDER |
| title_full | THE EFFICACY OF ANTIHYPERTENSIVE TREATMENT COMBINATION WITH ANXIOLYTICS IN HYPERTENSIVES WITH ANXIETY DISORDER |
| title_fullStr | THE EFFICACY OF ANTIHYPERTENSIVE TREATMENT COMBINATION WITH ANXIOLYTICS IN HYPERTENSIVES WITH ANXIETY DISORDER |
| title_full_unstemmed | THE EFFICACY OF ANTIHYPERTENSIVE TREATMENT COMBINATION WITH ANXIOLYTICS IN HYPERTENSIVES WITH ANXIETY DISORDER |
| title_short | THE EFFICACY OF ANTIHYPERTENSIVE TREATMENT COMBINATION WITH ANXIOLYTICS IN HYPERTENSIVES WITH ANXIETY DISORDER |
| title_sort | efficacy of antihypertensive treatment combination with anxiolytics in hypertensives with anxiety disorder |
| topic | arterial hypertension ambulatory blood pressure monitoring anxiety anxiolytics tofisopam |
| url | https://russjcardiol.elpub.ru/jour/article/view/666 |
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