Clopidogrel therapy effects on cell hemostasis in acute coronary syndrome
The study was aimed at investigating cell hemostasis parameters in acute coronary syndrome (ACS), and comparing the effects of various antiaggregant medications (clopidogrel, aspirin, or their combination) on platelet (PL) and red blood cell (RBC) aggregation activity. In total, 98 ACS patients were...
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2008-12-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/1642 |
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| author | R. A. Rakhimova B. A. Alyavi M. L. Kenzhaev L. Sh. Davlatova |
| author_facet | R. A. Rakhimova B. A. Alyavi M. L. Kenzhaev L. Sh. Davlatova |
| author_sort | R. A. Rakhimova |
| collection | DOAJ |
| description | The study was aimed at investigating cell hemostasis parameters in acute coronary syndrome (ACS), and comparing the effects of various antiaggregant medications (clopidogrel, aspirin, or their combination) on platelet (PL) and red blood cell (RBC) aggregation activity. In total, 98 ACS patients were divided into groups, according to the antiaggregant therapy received. At Days 3-4 and 6-7, PL aggregation activity and RBC morphology and function were assessed. Antiaggregant therapy was highly effective among those receiving combined treatment, with minimal PL aggregation and maximal RBC morphology improvement (high prevalence of discocytes and reversibly deformed RBC) observed as early as Day 3 and further increasing by Day 7. All three variants of antiaggregant therapy were significantly effective, but Clopidogrel, especially in combination with aspirin, demonstrated the best effect. Combined therapy (clopidogrel and aspirin) improved cell hemostasis parameters, which could be linked to better aggregation inhibition due to different therapeutic targets for these two agents. |
| format | Article |
| id | doaj-art-91b7db18cd304b699d58950c2ac40179 |
| institution | Kabale University |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2008-12-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-91b7db18cd304b699d58950c2ac401792025-08-20T03:57:26Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202008-12-010633371427Clopidogrel therapy effects on cell hemostasis in acute coronary syndromeR. A. Rakhimova0B. A. Alyavi1M. L. Kenzhaev2L. Sh. Davlatova3Республиканский научный центр экстренной медицинской помощи, ТашкентРеспубликанский научный центр экстренной медицинской помощи, ТашкентРеспубликанский научный центр экстренной медицинской помощи, ТашкентРеспубликанский научный центр экстренной медицинской помощи, ТашкентThe study was aimed at investigating cell hemostasis parameters in acute coronary syndrome (ACS), and comparing the effects of various antiaggregant medications (clopidogrel, aspirin, or their combination) on platelet (PL) and red blood cell (RBC) aggregation activity. In total, 98 ACS patients were divided into groups, according to the antiaggregant therapy received. At Days 3-4 and 6-7, PL aggregation activity and RBC morphology and function were assessed. Antiaggregant therapy was highly effective among those receiving combined treatment, with minimal PL aggregation and maximal RBC morphology improvement (high prevalence of discocytes and reversibly deformed RBC) observed as early as Day 3 and further increasing by Day 7. All three variants of antiaggregant therapy were significantly effective, but Clopidogrel, especially in combination with aspirin, demonstrated the best effect. Combined therapy (clopidogrel and aspirin) improved cell hemostasis parameters, which could be linked to better aggregation inhibition due to different therapeutic targets for these two agents.https://russjcardiol.elpub.ru/jour/article/view/1642acute coronary syndromeplatelet aggregationantiaggregant therapyred blood cell structure and functionclopidogrel |
| spellingShingle | R. A. Rakhimova B. A. Alyavi M. L. Kenzhaev L. Sh. Davlatova Clopidogrel therapy effects on cell hemostasis in acute coronary syndrome Российский кардиологический журнал acute coronary syndrome platelet aggregation antiaggregant therapy red blood cell structure and function clopidogrel |
| title | Clopidogrel therapy effects on cell hemostasis in acute coronary syndrome |
| title_full | Clopidogrel therapy effects on cell hemostasis in acute coronary syndrome |
| title_fullStr | Clopidogrel therapy effects on cell hemostasis in acute coronary syndrome |
| title_full_unstemmed | Clopidogrel therapy effects on cell hemostasis in acute coronary syndrome |
| title_short | Clopidogrel therapy effects on cell hemostasis in acute coronary syndrome |
| title_sort | clopidogrel therapy effects on cell hemostasis in acute coronary syndrome |
| topic | acute coronary syndrome platelet aggregation antiaggregant therapy red blood cell structure and function clopidogrel |
| url | https://russjcardiol.elpub.ru/jour/article/view/1642 |
| work_keys_str_mv | AT rarakhimova clopidogreltherapyeffectsoncellhemostasisinacutecoronarysyndrome AT baalyavi clopidogreltherapyeffectsoncellhemostasisinacutecoronarysyndrome AT mlkenzhaev clopidogreltherapyeffectsoncellhemostasisinacutecoronarysyndrome AT lshdavlatova clopidogreltherapyeffectsoncellhemostasisinacutecoronarysyndrome |